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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#851

Post by ap99 »

rpunkfu wrote: post #691
ap99 wrote: post #503

This, like much of the pharmaceutical approach to well-being, is treating symptoms and not the problem. Metabolic dysfunction? Fix the metabolism. Poor understanding of nutrition? Fix the understanding. Lack of emotional or self-control? Fix the discipline. Obesity is largely NOT an acute symptom and does not need an acute solution. If you don't fix the underlying problem you will have weight issues your whole life (…

I believe that while your points are valid, they play a much more important role than merely serving as a tool for someone who doesn't want to delve deeper into the problem. I don't think being on Ozempic for an extended period is a good idea. This isn't because it's unhealthy, but because people often become leaner while still consuming unhealthy food. The difference is that they now exclusively eatthat unhealthy fo…

The problem I have with ozempic is that it's a bandaid on a deep wound.

If I can take ozempic, eat poorly (just less volume), and still lose weight then my and most people's lazy brain will say keep doing what you're doing.

When people get off ozempic they go back to the larger volume eating, and gain weight back which is mostly fat.

It's the epitome of a pharma solution: quick results, don't address underlying issues, hook the customer for life.

Re: Ozempic shows anti-aging effects in trial

#852

Post by Fargren »

nurettin wrote: post #748
Fargren wrote: post #493

Earlier quoted context omitted.

The way Japan "solves" obesity is quite cruel on those it does not work for. Overweight natives are not treated kindly. I think creating a medicine to make this easier is a moral good, and a sign of kindness and intelligence. Hopefully the aliens also agree.

Who does it not work for? (it being light eating and exercise, not some draconian torture)

Some people don't lose weight as easily as others, due to genetics, medical treatment, disability... And even some others have the freedom to not invest as much effort on losing weight.

Point being: there are overweight Japanese, despite the existence of the measures Japan takes to avoid it. These are the people I mean that it doesn't work for. And for those people, they don't have to deal only with the consequences of being overweight, they also have to deal with being treated very poorly. You can say it's for their own good, and the it incentives them to better themselves. Regardless, it still sucks for them.

Shaming people into losing weight may work, on aggregate. I'm not entirely convinced it's a good way to go about it, at the individual level.

Re: Ozempic shows anti-aging effects in trial

#853

Post by nlitened »

anitil wrote: post #842
nlitened wrote: post #827

Earlier quoted context omitted.

> If it is a moral failing, how can a pill resolve it? It doesn't. If thievery is a moral failing, how can chopping off thief's hands resolve it? It does resolve further thievery, but doesn't resolve the moral failing of it.

I'm not sure I understand your point, maybe we're talking at cross purposes? In the case of chopping off a thief's hand I see the _desire_ to steal as the moral failing. Preventing the physical theft in that case doesn't resolve the moral failing. In the alcohol case, (some) people who take naltrexone completely lose the desire to drink, so the internal _desire_ (or 'moral failing') has resolved, rather than just the…

I probably need to reconsider my assumptions, you’re right. I thought that taking naltrexone only manages addiction for as long as it’s being taken, and after it’s stopped the desire returns.

If it just cures the bad habit without the mental work, then probably it would be more appropriate to view it as a remedy for a disease rather than a temporary band-aid for people who are unwilling to put in the work.

Re: Ozempic shows anti-aging effects in trial

#854

Post by tomhow »

ACCount36 wrote: post #840
y-curious wrote: post #822

Earlier quoted context omitted.

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Re: Ozempic shows anti-aging effects in trial

#855

Post by tomhow »

y-curious wrote: post #822
ACCount36 wrote: post #789

Earlier quoted context omitted.

[dead]

[flagged]

That commenter's behavior was egregious and we've banned them, but we also need you to avoid escalating flamewars. We'd appreciate you taking a moment to read the guidelines and making an effort to observe them in future.

https://news.ycombinator.com/newsguidelines.html

Re: Ozempic shows anti-aging effects in trial

#856

Post by Nesco »

cthalupa wrote: post #830
Nesco wrote: post #825

Earlier quoted context omitted.

Uncouplers are particularly useful to make sure your metabolism doesn’t slow down, which makes getting off those drugs when reaching the right body fat percentage without regaining everything way easier

Losing weight through any method will make your metabolism slow down - fat is metabolically active. Uncouplers won't change this. Even if 100% of your weight loss is fat, your BMR is going to drop. The amount of metabolic adaptation from caloric deficits is grossly overstated by many people, and the "starvation mode" adaptation is temporary. Just reaching a maintenance level of calories for a relatively short period…

Let’s be real: both of us have no idea of how it would play out. Pharma companies will try to add them to their stack at some point, and then the real world data we currently lack will decide for everyone

Re: Ozempic shows anti-aging effects in trial

#857

Post by a5c11 »

JumpCrisscross wrote: post #818
a5c11 wrote: post #807

Earlier quoted context omitted.

> The fact that it's treatable with a drug should have put this nonsense to bed. You can "cure" brain tumour with painkillers too. That's the same thing - silencing symptoms, while the cause persists. > precisely measure their diet and exercise, gain a pound or two If they exercise, that's normal they gain weight. Muscles build up, the body keeps some more water - that's natural. Weight isn't the only measure, especi…

> can "cure" brain tumour with painkillers too. That's the same thing - silencing symptoms, while the cause persists Bad comparison. Taking painkillers doesn’t cause the underlying condition to go away. GLP-1 agonists do. The obesity goes away. The inflammation goes away. Hell, the dietary choices get changed. In some cases, including ones I’ve personally seen multiple times now, even after treatment is stopped. > If…

> They’re not gaining a persistent few pounds of muscle in a week that then get worked off with exercise.

So it's water. Btw, do they also report every meal they ate to you? I doubt. People are lying, so I wouldn't trust in their calories counting.

> The obesity goes away.

Just like pain, obesity is a symptom of something else being broken - diet, serious illness, mental issues, invalid hormone levels, etc. Sure you probably can get rid of obesity with a magic pill, but the underlying problem persists. Obesity doesn't come from the air - basic laws of physics.

> One group with fewer and fewer transmissible diseases, without obesity, aging slower.

That's precisely what healthy lifestyle does to the human body. You don't need to pay for magic pills, just keep balanced diet, exercise, sleep well.

> The other anti-vax, anti-medicine and whatnot.

Being sceptical about what you put into your body is wise. Not every vaccine is needed. Not every medicine is there to help you.

Re: Ozempic shows anti-aging effects in trial

#858

Post by nurettin »

Fargren wrote: post #852
nurettin wrote: post #748

Earlier quoted context omitted.

Who does it not work for? (it being light eating and exercise, not some draconian torture)

Some people don't lose weight as easily as others, due to genetics, medical treatment, disability... And even some others have the freedom to not invest as much effort on losing weight. Point being: there are overweight Japanese, despite the existence of the measures Japan takes to avoid it. These are the people I mean that it doesn't work for. And for those people, they don't have to deal only with the consequences…

Let's be generous and say that a person's body runs on 1600kcal/day, which is pretty low and the other 1800kcal/day which is kinda average. The difference in weight loss between these two over six months eating and exercising is negligible. The maths just doesn't math.

But to be fair It may be psychological. Eating is a very common coping mechanism and not taking care of your body is a common symptom of stress and depression.

Re: Ozempic shows anti-aging effects in trial

#859

Post by jart »

ponector wrote: post #785
jart wrote: post #579

Earlier quoted context omitted.

And it's thanks to that kind of dishonorable practice that $NVO has lost 64% of its value over the last year. This is how the world rewards the makers of the most successful and helpful drug in history.

I always thought penicillin is the most successful and helpful drug. As well as vaccines against deadly diseases.

Can't argue with that.

Re: Ozempic shows anti-aging effects in trial

#860

Post by lo_zamoyski »

guerrilla wrote: post #808
lo_zamoyski wrote: post #712

Earlier quoted context omitted.

So you accept it as a behavioral problem, yes? I.e., an inability to refrain from overeating? Any speculation about why you cannot deny yourself?

No, it's not a "behavioral problem." Your phrasing is disgusting. The research is perfectly clear on why it's extrenely difficult to lose weight. There's no need for speculation.

So, you reject thermodynamics? Phrases like "the research" is a convenient way to insinuate and bluff.

Obesity is absolutely a behavioral problem.

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