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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#831

Post by const_cast »

fc417fc802 wrote: post #777
const_cast wrote: post #773

Earlier quoted context omitted.

I'm explaining why your claimed observation is bullshit. And, for the record, you haven't provided any evidence either. You're just "saying your observations". And, let's all be real here, skinny person to skinny person. Most skinny people are extraordinarily biased against ozempic because they lose moral high ground to people they dislike. I think a lot of skinny people want to desperately believe they are special o…

I'm not the same person you were responding to earlier? You seem rather emotionally wound up in all of this. Someone doesn't need "evidence" to say "I noticed A". The evidence is right there - they're claiming to have seen it. Among other things, you've put yourself in the position of claiming - but not arguing, because you provide no reasoning to engage with - that there are no black swans in the world. It's entirel…

What I'm claiming is there's zero evidence that ozempic causes buccal fat loss more than any other weight loss methods. There isn't even a mechanism for that. We even know for a fact that spot reducing fat is impossible.

If you claim differently, the burden of proof is on YOU. Not me.

Your observations be damned. Elephant in the room: observations from biased actors are less than worthless.

The reason this observation came to be is because people seek an easy way to punch down on ozempic users and differentiate their weight status from ozempic users. I've already explained that.

Re: Ozempic shows anti-aging effects in trial

#832

Post by perching_aix »

42772827 wrote: post #821
perching_aix wrote: post #801

Earlier quoted context omitted.

I'm pretty okay with semaglutide and I understand its prospective benefits, both on a personal and societal level. My point was that the father of this person clearly has that oh-so-superior and elusive brain chemistry you suppose I have based on the account shared, so it was both immensely asinine to write what you did, as well as straight up false. That you could have went through all these other points without bei…

You made the story about you, when nobody asked. Check the comment I responded to. You did exactly what people always seem to jump out of their seats to do when this drug is mentioned: crowd the conversation with anecdata about how you did it better.

It's blatantly obvious that what I said was an anecdote and what benefits semaglutide harbors. I'm well aware and am in full agreement with it. Always has been. Now if only you condeded to having been unnecessarily and disproportionately hurtful.

Re: Ozempic shows anti-aging effects in trial

#833

Post by kjkjadksj »

elzbardico wrote: post #819
kjkjadksj wrote: post #26

Earlier quoted context omitted.

People on ozempic certainly look more like the crypt keeper than a younger version of themselves. You lose all that buccal fat that defines your young adult face.

Losing facial fat will only make you look older if your skin has low elasticity and/or if you lose too much fat, too much fast. Also, it is very common for people that start eating dramatically less to also reduce their water intake too much and become dehydrated. Besides ensuring you're getting sufficient water, there are a lot of dermatologic procedures that can help you to recover at least some of your skin elasti…

Fillers and facelifts also look bad and don’t last

Re: Ozempic shows anti-aging effects in trial

#834

Post by kjkjadksj »

JumpCrisscross wrote: post #699
kjkjadksj wrote: post #26

Earlier quoted context omitted.

People on ozempic certainly look more like the crypt keeper than a younger version of themselves. You lose all that buccal fat that defines your young adult face.

> lose all that buccal fat that defines your young adult face The people who should be taking Ozempic aren't lacking in buccal fat.

Sure. But plenty of seemingly not fat people take it which is when things go awry with the gaunt look imo. Lots of celebs in their 30s 40s 50s with transformed skin on bone faces as a result of this stuff.

Re: Ozempic shows anti-aging effects in trial

#835

Post by kjkjadksj »

YokoZar wrote: post #69
kjkjadksj wrote: post #26

Earlier quoted context omitted.

People on ozempic certainly look more like the crypt keeper than a younger version of themselves. You lose all that buccal fat that defines your young adult face.

It varies. People are often thinner in their twenties than their thirties and forties. If you browse some before and after pictures the ones who have had their skin tighten tend to look younger for that reason alone.

Even naturally thin people have buccal fat and healthy looking cheek and jawlines.

Re: Ozempic shows anti-aging effects in trial

#836

Post by ProfessorLayton »

perching_aix wrote: post #398
42772827 wrote: post #235

Earlier quoted context omitted.

He could have lost all that weight and still had bread, sugar, and potatoes but instead he gave up what he clearly enjoyed. Now he gets to live out the rest of his life fighting cravings, telling himself he's not allowed to enjoy food. How utterly sad.

> Now he gets to live out the rest of his life fighting cravings, telling himself he's not allowed to enjoy food. How utterly sad. I don't understand what drives people to write such intentionally asinine comments. Do you get off on hurting others or something? There were quite a few foods I let go of when I decided to drop weight. Can't say I miss them much, certainly not to the extent to say something like "wow, i…

Additionally, some of us give up foods for reasons other than weight loss. I have no weight issues today, nor have I personally struggled with it in the past, yet I also gave up stuff like drinking soda because diabetes runs in my family.

While I do miss it sometimes, I'm perfectly fine with sparkling water. Sure I'll have soda once in a while, but it's now officially a "treat", and not all that sad about it.

If I ever struggle with weight gain in the future, I see no reason to skip a tool that makes that much easier.

Re: Ozempic shows anti-aging effects in trial

#837

Post by nomel »

johncolanduoni wrote: post #796
nomel wrote: post #776

Earlier quoted context omitted.

> Just that demanding every drug be used for 30+ years before you’ll touch it is not actually making an analysis of the tradeoffs involved. Your replies are unnecessarily aggressive, and you’re not reading comments in a charitable way, or keeping track of the usernames writing them. Nobody is saying this.

I also never said we were “immune to unintended consequences”. How charitable was putting those words in my mouth? Also not sure where your quip about me not keeping track of usernames came from - I responded to specific examples given in each individual comment. They just both happened to bring up benzodiazepines.

I would strongly suggest re-reading this chain, and your replies, and trying to take what people are saying more charitably.

>> Also not sure where your quip about me not keeping track of usernames came from

You said "neither were you", but that was djtango's first reply to you:

> I wasn’t talking about non-pharmaceuticals, and neither were you

And the most recent example:

> I also never said we were “immune to unintended consequences”. How charitable was putting those words in my mouth?

I didn't do any of that. It's actually completely unrelated to my comment and how you're presenting yourself.

Re: Ozempic shows anti-aging effects in trial

#838

Post by throwawaylaptop »

peterldowns wrote: post #679
throwawaylaptop wrote: post #146

Earlier quoted context omitted.

You can be gluttonous and still thin. I eat 2 lbs of ground beef a day, with tons of cheese on it. For breakfast I have 6-8 eggs, with cheese. I have my morning coffee with heavy whipping cream. For desert, I whip up some of the heaving whipping cream and have it with frozen berries thawed out. It drives gfs nuts but they're too anti fat to try it.

That's like 4000 calories. How much do you weigh / what's your exercise like?

I'm 6'4", 205. It's probably closer to 3000 calories. But then I also skip meals other than dinner when I'm super busy, which probably averages me out lower. It's a lot easier to skip meals when your body is used to burning fat for energy instead of carbs.

Re: Ozempic shows anti-aging effects in trial

#839

Post by wisty »

benchly wrote: post #502
wisty wrote: post #495

Earlier quoted context omitted.

Evolution should make intelligent choices for us but there's thousands years where a few extra pounds meant surviving a famine. Also I bet it will kill a few people with eating disorders. As long as you're in a 1st world country and have a BMI over ... maybe 25 (and aren't on steroids so you're both anorexic and overweight at the same time) I'd guess you're dodging a lot of the most obvious risks.

How do you define 'intelligent' and 'evolution?' I think we might differ on what those words mean, which would make this conversation difficult, so let's clarify where each of us is coming from. My understanding (which may be slightly misguided because this is definitely not my field) is that Intelligence is the ability to use information for reasoning, decision making and achieving understanding. This ability, as a…

The OP said something about how the human body doesn't make "intelligent" decisions.

I was being cheeky, not using the best word for the job.

Evolution is not really passive, it's a combination of mutation (which is not intelligent, but not really passive) PLUS a passive filter, which gives the illusion of intelligence since it ends up as a kind of optimiser.

Now, due to various factors, evolution isn't perfect. For gene expression reasons (I think) the layout of mammal skeletons are not really effected much mutations, but bone sizes are; so you have giraffes with huge neck bones that are the same size as human neck bones (this isn't the best way to do it). You have bats with the same finger bones as humans (or at least very similar) acting as wings. Elephant feet are almost the same as human feet in an x-ray. Some genetic "knobs" are easier to turn than others, and it can be that shrinking something is easier than getting rid of it. Just google "vestigial structure". Actually, LLM are kind of similar (it's easier to optimise a value to zero than to remove it, even if removing a value will make the model better and faster).

It's also more adaptative than optimal. Some argue it's the "selfish gene" that "wants" to be passed on. If a gene makes you kill all the competition, that's a "fit" gene. If working in a team increases the survival rate of your cousins (who also kind of carry your genes) it's "fit". If having a certain percent of a village be gay would somehow increase survival rates (especially of their kin) then having a chance of being gay is "fit" even if the individuals themselves could be less likely to reproduce.

There's also some meta stuff about how the rate of mutations could partly be genetic.

Evolution is seen as intelligence because it solves hard problems, and IMO that's kind of the only thing intelligence needs? People who talk about "consciousness" talk a lot about how they think they think, but is how we think actually an illusion? The feeling of understanding is just a chemical pleasure hit when the brain hits the "problem solved" button. Consciousness might be an illusion, we might make a decision and wonder how we made it, then an AI in our brain quickly justifies it in some BS way that isn't actually our real thinking process.

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