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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#821

Post by 42772827 »

perching_aix wrote: post #801
42772827 wrote: post #763

Earlier quoted context omitted.

>There were quite a few foods I let go of when I decided to drop weight. Can't say I miss them much, certainly not to the extent to say something like "wow, i can't enjoy food anymore" or "now i'm fighting cravings all the time!!". And I legitimately have no interest in reintegrating them into my diet. Your story has been told over and over and over. We get it. Congratulations. You win. You don't need GLP1s to sustai…

I'm pretty okay with semaglutide and I understand its prospective benefits, both on a personal and societal level. My point was that the father of this person clearly has that oh-so-superior and elusive brain chemistry you suppose I have based on the account shared, so it was both immensely asinine to write what you did, as well as straight up false. That you could have went through all these other points without bei…

You made the story about you, when nobody asked. Check the comment I responded to. You did exactly what people always seem to jump out of their seats to do when this drug is mentioned: crowd the conversation with anecdata about how you did it better.

Re: Ozempic shows anti-aging effects in trial

#823

Post by ablation »

wonderwonder wrote: post #632
b800h wrote: post #427

Earlier quoted context omitted.

The other side of this is related to morals. People learned self-discipline by having to moderate their diet. Replacing that challenge with an injection is another example of a world in which people are not challenged to grow as people, but merely go out and buy something to make themselves feel or look better.

This has failed though. Over 40% of Americans are obese. This costs us as a society hundreds of billions in healthcare costs, much of it federally subsidized. Being obese is a simple choice now, one can choose to be fat or choose to take a once weekly shot and not be fat. Take Elon Musk, he is clearly overweight. Is your argument that he lacks self-discipline as a person and is as such a complete failure? Of course n…

> Of course not, the man is clearly more disciplined and driven than most people.

Driven by huge amounts of ketamine and a pathological need to reproduce, perhaps.

Re: Ozempic shows anti-aging effects in trial

#824

Post by zoeysmithe »

theshackleford wrote: post #520
zoeysmithe wrote: post #104

Earlier quoted context omitted.

I think this might be revisionism. A lot of people feared early anesthesia because it was far more dangerous than today. I also notice people will make note that 'eccentrics' from the 1940s-1950s hated air conditioning but it helps to understand it was a dangerous technology that regularly injured and killed people back then, especially in its earlier days the adults of that period were children during. AC didn't get…

> because full anesthesia does regularly injure, disable, and kill people Disability or death are both incredibly rare side effects in modern usage and do not at all fit any pattern you could attach to the word “regular.”

Its under documented. People having side effects and injuries from these drugs post-surgery are just told to "deal with it." Modern medicine is quite an improvement from the past but it still involves a great deal of risk, especially when we put people fully under.

Re: Ozempic shows anti-aging effects in trial

#825

Post by Nesco »

cthalupa wrote: post #812
loeg wrote: post #797

Earlier quoted context omitted.

But why? Ozempic et al solve the input end of the equation. Burning more and literally being warmer isn't better.

I would agree, personally - I won't go near DNP, and even the newer stuff like BAM15 that is supposed to be incredibly selective I am quite suspicious of. But you still see people losing tons of weight on GLP-1s wanting it to go faster, drop more pounds, etc. I'm a big proponent of them - and I have enough risk tolerance that I'm on grey market retatrutide - but I see a lot of people that want to just keep adding mor…

Uncouplers are particularly useful to make sure your metabolism doesn’t slow down, which makes getting off those drugs when reaching the right body fat percentage without regaining everything way easier

Re: Ozempic shows anti-aging effects in trial

#826

Post by lm28469 »

ben_w wrote: post #751
lm28469 wrote: post #602

Earlier quoted context omitted.

The truth is that we designed a system in which a majority of people cannot thrive and in which a lot of people end up developing problems like obesity or being labeled as ADHD. Now the same system designed a cure, one that you have to pay for and take for years if not for life, just so that you can rewire your perfectly normal brain to fit in the very imperfect mold of what the system needs Taking antidepressant won…

> The truth is that we designed a system in which a majority of people cannot thrive and in which a lot of people end up developing problems like obesity or being labeled as ADHD. We designed — if you can call this "design" — a system where most people are not the literal property of their feudal lords and most of them do not need to worry about literally starving to death. Our genomes don't know we're not at constan…

> We designed — if you can call this "design" — a system where most people are not the literal property of their feudal lords

hm really ? https://simple.wikipedia.org/wiki/Technofeudalism

> and most of them do not need to worry about literally starving to death.

Yes, now the main causes of death are literal sloth and gluttony.

> living longer and healthier lives

Healthier ? 50% of people are basically disabled by the age of 40 because of obesity

You're conflating life expectancy at birth vs life expectancy, don't forget health-span expectancy either. The US life expectancy is going down, health span is going down in most of the west too:

https://www.cnbc.com/2024/10/09/life-spans-are-growing-but-h...

https://www.healthsystemtracker.org/wp-content/uploads/2025/...

Anyways, if your argument is that we should be glad that 70% of people are overweight/obese because people died earlier 300 years ago idk how many people you will convince...

Re: Ozempic shows anti-aging effects in trial

#827

Post by nlitened »

anitil wrote: post #783
nlitened wrote: post #419

Earlier quoted context omitted.

Alcoholism is a moral failing, and the struggle and punishment are real, and come not only from outside, but also from within. One can try to rationally argue their way out of alcoholism being a moral failing, but then one notices that in a similar way they can “whitewash” any other moral failing, and the words lose their meaning completely. Yet people use these words to mean something, and abuse of alcohol falls und…

If it is a moral failing, how can a pill resolve it? Does the pill put morals back in the user? While I agree that alcohol abuse is bad (and might make people do bad things, and hurts people around them etc), I'm not sure if the moral argument adds anything to the discussion

> If it is a moral failing, how can a pill resolve it?

It doesn't. If thievery is a moral failing, how can chopping off thief's hands resolve it? It does resolve further thievery, but doesn't resolve the moral failing of it.

Re: Ozempic shows anti-aging effects in trial

#828

Post by cthalupa »

rscho wrote: post #817
cthalupa wrote: post #809

Earlier quoted context omitted.

I really don't understand this skepticism around semaglutide and long-term effects. One, GLP-1s are not a new class of drug. We have had them in various forms for about two decades now. Two, the clinical trials have followed the standard sort of schedule as any other medication we release. I don't hear or see all the hand-wringing that these have received over every other medication we develop. Three, they are analog…

> silly unless your general stance is that you won't take any medication until that specific formulation has been on the market for decades Yes, I'd argue that this is the default stance for many healthcare professionals.

I'm sure it is the default stance for some.

Many is hard to quantify. In my experience it is not the majority, nor is it a stance that makes much sense to me in general.

Re: Ozempic shows anti-aging effects in trial

#829

Post by tracker1 »

declan_roberts wrote: post #792
tracker1 wrote: post #775

In my experience it also showed gastroparesis and fecal vomiting over the course of a couple years. Coming off meant the feeling of starvation 24/7 for about 11 months before starting to get better, and 1.5 years off the medication now, I'm still having digestive issues. Went back to keto (mostly carnivore) in May and a few pounds away from 50# down from my max weight, managed to cut way back on insulin (some days no…

You have fecal vomiting and stayed on the drug for years?

It's not like it started a day after I first took the drug, my gastro issues got worse over the course of the time I was on it. I didn't know it was being caused by it. I was literally seeing 3 doctors over the gastro issues... wasn't until the lawsuit against Trulicity that I put it together and stopped taking it.

But sure, it's MY fault I didn't figure out what several doctors didn't over the course of that second-third year or so.

Re: Ozempic shows anti-aging effects in trial

#830

Post by cthalupa »

Nesco wrote: post #825
cthalupa wrote: post #812

Earlier quoted context omitted.

I would agree, personally - I won't go near DNP, and even the newer stuff like BAM15 that is supposed to be incredibly selective I am quite suspicious of. But you still see people losing tons of weight on GLP-1s wanting it to go faster, drop more pounds, etc. I'm a big proponent of them - and I have enough risk tolerance that I'm on grey market retatrutide - but I see a lot of people that want to just keep adding mor…

Uncouplers are particularly useful to make sure your metabolism doesn’t slow down, which makes getting off those drugs when reaching the right body fat percentage without regaining everything way easier

Losing weight through any method will make your metabolism slow down - fat is metabolically active. Uncouplers won't change this. Even if 100% of your weight loss is fat, your BMR is going to drop. The amount of metabolic adaptation from caloric deficits is grossly overstated by many people, and the "starvation mode" adaptation is temporary. Just reaching a maintenance level of calories for a relatively short period of time is enough to reset it - but this change is minor to begin with. The majority of any metabolism slowing will occur purely as a function of weight loss.

The issue with regaining weight after coming off these drugs is that people don't change their habits, and once they are off, they no longer have the limited appetite, and return to eating like they did before, which just results in the problem reoccurring. Uncouplers won't change this.

If people want to sustain their weight loss, they either need to change their lifestyle and eating habits, or they need to stay on the drugs, and potentially even both.

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