This reflects a longstanding...essentially conspiracy...to suppress attention to 5HT2A-based neural regulation because it sheds such poor light on SSRIs
What are you talking about?
MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)
81–90 of 108 posts
Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)
#82These psychedelic treatments always have substantial limitations, and this is no different; 1. Low volume cohort i.e. 40 participants per dose group 2. Industry sponsored study i.e. MindMed. 3. Think about it; how do you blind psychedelics? It's pretty obvious you're on one when you take it.
I recall an experiment where the control group was given Ritalin, and the participants had presumably tried neither Ritalin or the psychedelic.
I thought it was pretty cool, since the control group will still "feel" something and potentially think "oh this is it" but since the effects of stimulants like Ritalin have been more studied, the researchers can easily account for it.
Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)
#83This will be like legal weed. Assuming it isn't already, the pharma bean counters will turn it into something awful.
Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)
#84> It's usually treated with medications like Zoloft and Paxil that boost and stabilize the neurotransmitter serotonin, leading to reduced anxiety and enhanced emotional well-being How do figure the boost and stabilize part for a patient? Do they take samples of neurotransmitters in the spinal fluid before and after and looking for neurotransmitter concentrations?
There's a divide in the marketing language vs the research language on this topic. Marketing says some handwavy statement like "Zoloft stabilizes serotonin levels", but the research on the topic basically says that we assume that's how it works based on what we know about the brain & the drug, but we don't actually have proof of the mechanism.
Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)
#85The "surprising way" is by using a derivate of LSD. I'd argue that the surprise is rather on this: "In clinical trials, a single dose significantly outperformed standard treatments, offering hope to those who have found little relief elsewhere."
That statement is not surprising to anyone who has taken LSD. However I would be surprised if the pharma version works as good as the original.
Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)
#86Why can we not just get plain LSD?
I have never heard a reasonable argument.
Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)
#87how about treating the cause for the anxiety?
Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)
#88Unfortunately, I will probably never be able to try that for my GAD even if they confirm the positive effects due to stigma surrounding psychoactive drugs! Yay!
Like, just don't tell anybody. And there are many things you haven't tried, like metabolic ketogenic therapy as an example.
Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)
#89I’d be afraid of a treatment like this where you’re sort of different after one treatment. From experience taking ssris, I took one one that worked so well that I had to stop taking it because it removed stress to the extent that I wouldn’t get to class on time or get my homework done before deadlines. Eventually I found a medicine that worked for me. But, if there’s a “before” vs “after” one shot treatment, you have…
Sounds like intended behavior. Instead of keeping working in shitty motivation loop (stress builds up so I will eventually get the stuff done), maybe changing habits a bit around your new me would be a better move, like doing tasks proactively as they come? Triple that if you were being cured for anxiety itself.
You got the chance for a more chill life compared to obviously more stressed one and you threw it away as 'too nice won't bother trying it'.
Re: MM120, a pharmaceutical form of LSD, shown to reduce anxiety symptoms (2025)
#90The psilocybin data tells a similar story. One or two sessions outperforming months of conventional meds. The fact that both LSD and psilocybin work on neuroplasticity probably isn't a coincidence. Hope regulators don't drag their feet on this for another decade.