81–90 of 122 posts
I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in the 0.1uM range and then taking off in the 1uM range. I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in…
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I suppose this might be why Willie Nelson is still doing pretty good these days...
You might have replied to the wrong comment. OP implied it would have no impact
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Synthetic cannaboids were also studied as a possible analgesic and at the doses required it caused brain damage. Which is honestly disappointing because a general purpose pain killer that isn't opioid based would be a miracle.
although the study is often labelled irreplicable, i do still believe in rat park. opiates are not evil in and of themselves; rather, society forms a structure around which the use of opiates easily becomes more alluring than contributing to said society. consequently, those in chronic pain are often forced to suffer needlessly by being deprived of relief, so that societal productivity is maximized. the real miracle…
What all that, how can you defend opiates? Opinion of society is irrelevant here, they are absolute scourge if used enough, and nobody is immune.
I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in the 0.1uM range and then taking off in the 1uM range. I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in…
Reminds me of this classic: https://xkcd.com/1217/
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Not really sure what you mean, I saw people on 10mg THC wring crazy code in a crazy speed. Some of them need it to be able to focus and think clear. Drugs never work "one way" for everybody. And its not only people its many things that affect how they work (setting, culture, education etc.). And if you think man kind does not need any drugs (including alcohol), if you look at it from a historic perspective we might e…
Unfortunately I know how THC works on me and it's not very desirable.
Rather frequent use (as in not every day all the day but lets say couple of times a week) can have some decline but IMHO its still temporary. If the brain is already used to lower learning and complex analysis activity then it will be compounded but otherwise it shouldn't. I sometimes fall here, and I integrate internal banking systems for a living for 2+decades in very competitive place plus raising family and have mortgages, so no shortage of stress. Any miniscule decline is more than compensated by relief of stress and some giggly happiness, plus that massive creativity spike which allows me to catch up with stuff slowly sliding out of focus (and then biting hard like bureaucracy, taxes etc). Literally subconsciousness sliding notes underneath the doors of my mind, topics often pop out of blue, in such frequency that I sometimes struggle to keep up and take notes since next one with higher priority comes and then next one.
Full on stoner - thats a goner, if we talk decades of use, I think. YMMV. But - I've met folks who had periods of life where they smoked all the time every day, for 5-10 years, usually teens (where I would say folks are very vulnerable since brain is still evolving). All are fine now in various roles in their lives.
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~~yes by 4 months. If I had AD i wouldn't bother with those treatments.~~ Sorry I missed the context you are right the fact that they slow AD by 4 months is a proof that amyloid plaques are part of the pathogenesis.
Or they have some other effect...
Get stupid now to avoid cognitive decline later? Not sure I like that tradeoff...
Not really sure what you mean, I saw people on 10mg THC wring crazy code in a crazy speed. Some of them need it to be able to focus and think clear. Drugs never work "one way" for everybody. And its not only people its many things that affect how they work (setting, culture, education etc.). And if you think man kind does not need any drugs (including alcohol), if you look at it from a historic perspective we might e…
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You might have replied to the wrong comment. OP implied it would have no impact
The joke is that Willie Nelson has used very high concentrations simultaneously frying his brain cells and staving off Alzheimer's.
Man, too bad weed gives me bad panic attacks. Alzheimers is the scariest disease I know so maybe if the studies pan out in time and it becomes a standard preventative, I might consider trying again. But somehow I doubt it will be found to be that effective.
I’ve found the edible thc (gummies/drinks) you get in non-legal states are much less panic/anxiety inducing. I’m not sure why but it probably has to do with CBD or something that is missing. It’s anecdotal but I’ve noticed it a lot. They also get you very high so I’m not sure how exactly they are getting around the legality requirement.
If you end up smoking high percentage THC with little to no CBD, those who with tactile brains will enter a state of negativity. Anxiety, paranoia et cetera.
Essentially just roll CBD leaf only with your main THC leaf and this should equal the balance but again this is all anecdotal and myself as experiment.