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Colon cancer now leading cause of cancer deaths under 50 in US

theguardian.com

81–90 of 226 posts

Re: Colon cancer now leading cause of cancer deaths under 50 in US

#81
post #9

Earlier quoted context omitted.

My money is on massive overexposure to high fructose corn syrup in the Western diet. https://pmc.ncbi.nlm.nih.gov/articles/PMC9170474/

Western means the US in your context. Western europe does not have that or whatever we consider not "easter diet".

Not Easter diet is also known as a low-cacoa diet.

Re: Colon cancer now leading cause of cancer deaths under 50 in US

#82

Scary. I had whole-genome sequencing done and the results came back with dozens of "Increased risk for colo-rectal cancer" results. I'm likely going to die of either a heart attack (already had one, at age 28), or cancer, and it seems genetic. EDIT: Specific genes and alleles below, if anyone is curious https://i.imgur.com/szplWSj.png

Probably nothing to worry about. Unless it is lynch syndrome.

Re: Colon cancer now leading cause of cancer deaths under 50 in US

#83

So many folks that have it say things like "I was super healthy! Did exercise, young, don't drink, etc." Then you dig deeper and realize the last vegetable meal they ate was a soggy brussel sprout their mom made them when they were 17 years old, and also eat cold cut turkey sandwiches every lunch because they're "healthy", and maybe have a tiny shred of lettuce in the sandwich. For breakfast, they eat pancakes or sug…

https://realfood.gov/

Let's keep in mind that this is the recommendation from the same government that recently declined to regulate dangerous pesticides [1] and relaxed regulations on additives [2].

The current US administration is not at all interesting in addressing America's unhealthy food.

[1] https://cen.acs.org/environment/pesticides/glyphosate-roundu...

[2] https://www.fda.gov/news-events/press-announcements/fda-take...

Re: Colon cancer now leading cause of cancer deaths under 50 in US

#84

Earlier quoted context omitted.

Which state did you have it done in if I may ask? I'm in Oregon and haven't been able to find a doc that does it without sedation. I can't be put under sedation for medical reasons, but I definitely need this procedure done sooner than later due to new GI problems.

I had a colonoscopy and esophagogastroduodenoscopy (thankfully not in that order) without sedation. Had it done in D.C. My doc looked at me like I was crazy when I asked if it could be done without sedation, and reminded me that it would be uncomfortable, but otherwise didn't have any problem with it. I've endured 50k runs, brutal workouts, and traumatizing childhood neglect - I really can't see what the fuss is with…

I too had esophagogastroduodenoscopy and the "sedation" I received as a barely noticeable dose of fentanyl. It was unpleasant to feel like I was drowning in saliva but it was quite bearable.

If I ever receive that procedure again, I will ask to skip the fentanyl microdose. The anesthesia and the buzz were not only underwhelming but for some reasons I started to feel the typical opioid warmth when the procedure was almost completed. Had they waited a few minutes after the IM injection I might have had another opinion on the usefulness on fentanyl during endoscopie because the last 30s were almost pleasant!

Re: Colon cancer now leading cause of cancer deaths under 50 in US

#85
post #78

Earlier quoted context omitted.

That's such a big disparity I'm very suspicious of that data, but there seems to be plenty of evidence that grossly excessive cardiovascular exercise is bad for you in various ways. If people enjoy it and really get a lot out of it then I wouldn't judge them for doing it, but let's not pretend it's healthy, because all the evidence is that it isn't. In terms of cardio being able to run a half decent 5k a couple of ti…

Claiming that distance running is unhealthy is wild. It can lead to injury, and there's such thing as overtraining. But to claim that it's broadly unhealthy is just wrong

[deleted]

Re: Colon cancer now leading cause of cancer deaths under 50 in US

#86

I think part of this can be attributed to prolonged gut inflammation caused by toxins and parasites. There’s something like 60% of the population has some form of parasite and have no idea, which causes a lot of inflammation and problems. Problems that don’t necessarily point to the gut being the culprit on the surface. So it’s misdiagnosed a lot. I recommend everyone do a gut cleanse once a year.

CDC estimates about 60 million are effected by parasites in USA. which is about 17 or 18%.

Gut cleanse, colon cleanse, detoxing. None of this is supported by science. Nor would any of these things cure, prevent or in anyway help a parasitic infection.

Here are some common parasitic infections and how they're treated. None of these treatments recommend gut cleanse. https://en.wikipedia.org/wiki/Giardia#Infection https://en.wikipedia.org/wiki/Toxoplasma_gondii#Treatment https://en.wikipedia.org/wiki/Ascariasis#Treatment https://en.wikipedia.org/wiki/Hookworm_infection#Treatment https://en.wikipedia.org/wiki/Pinworm_infection#Treatment

Gut inflammation can be a problem, but I would not recommend treating it or even diagnosing it without evidence.

Re: Colon cancer now leading cause of cancer deaths under 50 in US

#87
post #56

Quite scary since we don't know what causes it. I know there are some intelligent guesses, but my understanding is that we don't have any hard proof.

Hah, I've counted 10+ different intelligent(?) guesses in the replies.

I lean toward "people got better at not dying from everything else." It's plausible to me that it just enabled existing factors to unfold on the time scales they unfold on for more people.

My handy heuristic for headlines like this: Is it a scary new trend that means something or did other factors suppressing its natural emergence decline? Or is it a matter of observation?

A recent real-world example was the detection of two different objects entering the solar system. The naive speculation was "they came on the same plane, so they must be alien!" But the reality is more mundane: the new detection method that found them, while flexible, started by looking at that plane. So of course both objects it detected were on that plane.

Re: Colon cancer now leading cause of cancer deaths under 50 in US

#88

Ultra-marathoners have a 7x chance of getting colon cancer under 50. This is where it needs to be studied, maybe it's a common food or common supplement they are taking?

I remember when that paper hit HN the thinking was actually to do with reduced bloodflow to the colon while running for long periods of time.

Re: Colon cancer now leading cause of cancer deaths under 50 in US

#89
post #9

Earlier quoted context omitted.

My money is on massive overexposure to high fructose corn syrup in the Western diet. https://pmc.ncbi.nlm.nih.gov/articles/PMC9170474/

lack of fiber is a biggie too. Foods too highly processed. too many oils.

I usually stay out of health convos because it's just not my wheelhouse, but I think most people would benefit from extra fiber. It has an obvious direct benefit to your life the very next time you use the bathroom. I don't know if it is the answer to the rise of colon cancer; this is well studied and seems really easy to work with? We would surely know already. But I do know it's worth doing irrespective of that.

Re: Colon cancer now leading cause of cancer deaths under 50 in US

#90
post #68
post #52

Amazing how everybody in this thread has posted their pet theories as to cause: - insufficient fibre - too much high fructose corn syrup - too much milk - too much citric acid - toxins and parasites (gut cleanse!) - washing chicken in chlorine (voiced as hypothetical) - ultra-marathoners - maybe their supplements and too much carbs or dehydration? - too much processed junk - vitamin and mineral deficiencies - radiati…

Throw return to office in there. You know it's coming eventually.

Call it: RTO causes colon cancer, or WFH causes colon cancer?
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