Earlier quoted context omitted.
I don't fully understand the under the hood mechanics of mmap, but I can sense that you're trying to convey that mmap shouldn't be used a blanket optimization technique as there are tradeoffs in terms of page fault overheads (being at the mercy of OS page cache mechanics)
Tradeoffs such as "if an I/O error occurs, the program immediately segfaults." Also, I doubt you're I/O bound to the point where mmap noticeably better than read, but I guess it's fine for an experiment.
And I/O bound programs are I/O bound whereas programs that aren't, aren't, so it really isn't meaningful to talk about whether "you" are I/O bound to the point that it's significant--maybe you are, maybe you aren't. I agree about experimentation.