Live data from Hacker News

Paracetamol disrupts early embryogenesis by cell cycle inhibition

academic.oup.com

81–90 of 217 posts

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#81
post #18

I've always had an (unreasonable?) dislike of Paracetamol/Tylenol ever since I found out it was the #1 cause of acute liver failure in the US. Liver failure is scary. https://en.wikipedia.org/wiki/Paracetamol_poisoning

Also extra damage if the liver is already busy with alcohol. So not good to take for a hangover.

This is why Ibuprofen is perhaps the better default painkiller.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#82
I won't take acetaminophen (usually) learning of the liver toxicity and low overdose potential. And I have a friend that destroyed his kidneys with ibuprofen and is on a transplant list.

But from what I understand acetaminophen also dulls emotional pain like from being fired or breaking up with a girlfriend which is interesting.

I still prefer to take neither if I can avoid it and I'll hurt a little bit instead. Hurt a lot and I'd probably change my mind though.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#84
post #76
post #18

I've always had an (unreasonable?) dislike of Paracetamol/Tylenol ever since I found out it was the #1 cause of acute liver failure in the US. Liver failure is scary. https://en.wikipedia.org/wiki/Paracetamol_poisoning

This send me into a whole rabbit hole. Mostly children get paracetamol overdose. Then I learned that in US/UK kids get paracetamol in liquid form with all kinds of flavours. Which is much harder to dose correctly when the kid spits or drools it out. Total culture shock for me, as in Europe the default for children is rectal ingestion (which is probably a culture shock as well for Americans). Any how, with pills it is…

Liquid Panadol flavors were totally useless with my son. He would spit it out or upset himself so much he'd throw it up.

We ended up crushing and diluting tablets in milk, which he would drink (you waste a lot of milk to hit the right factor).

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#85
post #79

Earlier quoted context omitted.

[flagged]

Yes, https://www.thisamericanlife.org/505/use-only-as-directed The episode shows how even small overdoses of acetaminophen can cause fatal liver damage, while decades of FDA delays and confusing drug labeling left millions of Americans at risk.

Tylenol is very safe if taken as prescribed. The overdose amount is relatively low, but not uniquely low.

The alternatives are worse - ibuprofen destroys your stomach lining if taken at the regular dose for too long.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#86
post #57
post #42

Earlier quoted context omitted.

Most, if not all, medication would carry a poisonous symbol, if it were not taken out of regulation for that. Mostly, you kill organs by any overdose. Roughly: - Paracetamol overdose can cause severe liver damage and may be fatal. - Ibuprofen in high doses can lead to kidney injury and stomach bleeding. - Aspirin overdose may result in salicylate poisoning, causing ringing in the ears, confusion, and metabolic acidos…

" Any medicine can be poison" is kinda missing the point. There is a rich and varied multidimensional field of danger, from aspects like the safety-margin between regular/dangerous dose levels, the chronology of how it can spike or accumulate, whether there's feedback in advance of damage, etc. Yeah, I can poison myself drinking clean water, but it's hard .

Thank you for this comment

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#87

It's probably worth mentioning that this drug is called Acetaminophen in the US, and is the active ingredient in Tylenol and other over the counter medicines.

[flagged]

It's a cheap and effective drug that has minimal side effects as long as you follow the instructions on the packaging. Pretty much all of the alternatives are worse.

Ibuprofen is usually rated to be on the same level (damaging your kidneys rather than your liver during long term use) but from what I've read I believe the potential side effects are more extreme (i.e. the elevated stroke/heart attack risk).

Using any pain medication for prolonged periods of time without consulting a doctor is dangerous. Many people do it, and most are absolutely fine, but when things go wrong, things go terribly wrong.

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#88
post #51

Earlier quoted context omitted.

As with all things, the poison is in the dose. A tonne of incredibly useful medicine can kill you if dosed incorrectly.

Sure but it’s pretty easy overdose on paracetamol. Since it’s a mild and really common painkiller, sometimes seen as not dangerous, someone uneducated about it who is really suffering could easily take 3 or 4 times the dose. Unlike a lot of drugs, you are not going to have a lot of immediate side effects if you overdose on paracetamol. You’ll just horribly die some days after,

[deleted]

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#89

Earlier quoted context omitted.

The general advice is to not take any medication during pregnancy without a physician’s advice. This includes all over the counter medicines.

Provide a reference please. Which country is that from?

Read a paper long time ago, something to do with increase of sulfur in the brain

Re: Paracetamol disrupts early embryogenesis by cell cycle inhibition

#90
post #54

Earlier quoted context omitted.

NSAIDs reduce inflammation. Since inflammation is part of healing, they can slow recovery, but they’re useful when inflammation itself is a problem.

paracetamol is not an NSAID.

Yes, but since the parent was talking about drugs with similar effects slowing healing, I thought it was appropriate to mention.
Post reply on HN