i haven't read it but i know the tl;dr. none of that shit works.
Review of Anti-Aging Drugs
81–90 of 176 posts
Re: Review of Anti-Aging Drugs
#82Ascorbic is not a correct name of a compound. Should be 'ascorbic acid' or Vitamin C. Such sloppiness cast doubt on accuracy of the whole review.
I mean this guy is not a scientist. He's an enthusiasts aping scientific process. Look at how he talks about the "10-20% flexibility". Hypothesis assumed true, no supporting evidence. Same with his idea of being young longer. No evidence supports this, yet his comments proceed as if it's a gospel truth
Re: Review of Anti-Aging Drugs
#83What's striking about "anti-ageing" research is how it keeps circling back to the same boring truths: don’t smoke, keep your weight down, move often, sleep properly, keep blood pressure and cholesterol in check, and go easy on the booze. If something makes an overweight, sedentary smoker hit 100, then it’s a miracle drug. Please let me know if/when you've seen that drug...
In the absence of actually lengthening the telomeres, everything falls short in the anti-aging department.
Most lifestyle habits contribute to shorting the telomeres as little as possible, which guarantees good health no matter the age, but still aging, albeit slower.
Given the current technology trajectory, many people including me, think that we are very close to totally stopping aging, and even reversing it.
Re: Review of Anti-Aging Drugs
#84There's a fascinating tension with anti-aging drugs, which is that your preference would obviously be to take them as early as possible, so you spend more time at a younger age as opposed to just prolonging the last years of your life, where you'll be stuck in a nursing home anyway. But taking experimental drugs while you're young is also much higher risk, and you might see people sacrificing their 20s for the sake o…
If we really manage to crack the code on aging, How certain are we that it's merely something to be delayed? Apparent age is at least somewhat reversible via lifestyle factors e.g. diet/exercise/sobriety.
In fact that's Aubrey de Grey's approach: rather than trying to figure out all the complicated processes involved in causing the damage in the first place, so you can slow them down, just directly fix the damage afterwards. There's been quite a bit of research on this.
Re: Review of Anti-Aging Drugs
#85> Fast for short intervals regularly, and longer fasts as they feel good to you. You can effectively do this every day if you just eat once per day. When I was properly obese, this technique resulted in rapid weight loss. Zero exercise was required to see results, which was good at the time because the not eating part was about all I could handle. Being in a fasted state is as close as you can get to actually reversi…
Associating weight loss with the healthiness of oneself is a mistake.
One can subsist on Oreos at a "healthy" weight if they consume <2,000 calories worth of cookies per day. They will not be a healthy person.
Re: Review of Anti-Aging Drugs
#86Earlier quoted context omitted.
And if diet alone isn't getting you to a healthy weight, the GLP-1 drugs are miraculously effective and don't have a lot of downsides aside from cost.
Is way too early to know about any downsides of these drugs. I’m afraid too many people are gonna find out the downsides when it’s too late.
These drugs have been around since 2005. Exenatide was approved by the FDA for use in 2005.
We've had plenty of time. Only their approval for weight loss is new
Re: Review of Anti-Aging Drugs
#87There's a fascinating tension with anti-aging drugs, which is that your preference would obviously be to take them as early as possible, so you spend more time at a younger age as opposed to just prolonging the last years of your life, where you'll be stuck in a nursing home anyway. But taking experimental drugs while you're young is also much higher risk, and you might see people sacrificing their 20s for the sake o…
Taurine and Vitamin E are readily available and seem prudent.
For melatonin, tryptophan plus niacin would maximize the serotonin pathway (note this is dangerous when used with SSRIs).
How many of these are easily available? I had no idea that royal jelly is sold as a supplement.
Re: Review of Anti-Aging Drugs
#88Earlier quoted context omitted.
Also this: > The best reason to take multiple life extension supplements is to hedge our bets, because we really don’t know which of them are effective in humans. And earlier: > Personally, I take large doses of rapamycin 2 days a week, 8 weeks per year. For personalized recommendations, you can consult your favorite life extension doc.
How to hedge a bet 101: 1.you bet on risky stuff using something of value (money, health,...) 2.since you're unsure whether your bet will pay off, you bet some more on some other risky stuff, just to be sure. BTW if you were wondering, of course all those proposed weird life-prolonging treatments are totally devoid of side-effects.
Oh there's plenty of people selling "side effect free" life extension supplements. But there's another name for side effect free medication: effect free.
Re: Review of Anti-Aging Drugs
#89Re: Review of Anti-Aging Drugs
#90I thought this was an informative post, but for many of these compounds the simple "life extension" metric is the one that is least interesting to me. I have no problem dying in my 80s or 90s, but I just want to ensure that as much as possible that I have a solid mind and body right up until I die. For example, my father has been taking metformin for nearly 30 years after surviving a heart attack in his 50s (he has t…
Diet and exercise are well know for the effect you're looking for. Its just not easy