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New treatment eliminates bladder cancer in 82% of patients

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Re: New treatment eliminates bladder cancer in 82% of patients

#81
post #8

My father currently suffers from bladder cancer, he's currently in palliative care, he's in Ukraine. If there are any medical professionals here, could someone provide an advice - is there any chance to get him access to TAR-200?

1.look for clinicaltrial on https://clinicaltrials.gov/ .

2.See if your father qualifies for any

3. Enroll

4. Get B2 visa. All medical treatment is usually covered once you are accepted into the program.

good luck!

Re: New treatment eliminates bladder cancer in 82% of patients

#82
post #13

Earlier quoted context omitted.

And for some reason a contingent of HN is cheering it on. We are breaking the innovation machine and pretending discoveries will just keep happening.

I'm probably part of the contingent you're alluding to. I'm not cheering. I am however a lot less likely to be depressed, mostly because whenever I tried to fact check a doom-like piece of news, I found it failing, hard. So now I'm at a "once every three months" rotation - which will of course change the first time I manage to confirm a piece of news. I am moderately pessimistic about the state of research because I…

US academia has a ridiculous amount of institutional entropy” — I wouldn’t count on that saving it. These institutions aren’t built for a top-down attack on the very core of how they operate. They’ve spent decades aligning to how grants are funded, how programs are run, how collaboration works. Now the government has blown that up — and done it in such a sloppy, unpredictable way that the institutions don’t even know how to react.

Re: New treatment eliminates bladder cancer in 82% of patients

#84

Earlier quoted context omitted.

You’re right, those bright, talented kids will just give up and quit their careers because US government funding has been reduced for research in their field. It’s so sad that the only way innovation can happen is if it’s funded by the government.

Just yesterday, I had a conversation with an MD/PhD at one of the major teaching hospitals in Boston. There is a lot of uncertainty right now - a lot of funding has already been lost, and there are real risks around more funding being lost in the future (just as one example, the administration's plans to limit reimbursement rates will cost the Boston area teaching hospitals hundreds of millions a year in research fun…

One of the best schools of public health in the country didn't admit any PhD students this year.

Re: New treatment eliminates bladder cancer in 82% of patients

#85
post #63

Earlier quoted context omitted.

>I am moderately pessimistic about the state of research because I do hear things I don't like, but this is compensated by my belief that US academia has a ridiculous amount of institutional entropy, and I'm perfectly willing with temporary issues if this means at least some of the long term problems will be improved I am confused how 'burn it all down' will solve any problems, let alone long term ones. You seem to h…

You quoted my comment, but you don't seem to be responding to it? I don't think I mentioned any burning it all down, nor anything you responded to, really.

Your 'pessimism' towards academia is the justification the 'burn it all down' people are using to ... burn it all down.

I'm not exaggerating. The innovation machine is currently ablaze. Even funded grants for things like cancer and alzheimers aren't being paid out because they fired all the grants processors. Multiple whole universities have been defunded entirely. An entire generation of scientists will have their careers stolen from them if this continues.

Re: New treatment eliminates bladder cancer in 82% of patients

#86

Earlier quoted context omitted.

The US isn't the only country with prestigious universities, that partially function on a form of social taxpayer welfare, that innovate in the medical field In fact, some other developed nations do it in far greater percentages of the universities' independent revenue. Many also have quite comparatively easy immigration paths for both students and workers.

The scale of the US research program, compared to the rest of the world, is about an order of magnitude difference.

The model proved itself, so consensus can be reached in other places to reach parity if the issue is important to them

Re: New treatment eliminates bladder cancer in 82% of patients

#87
post #14

Earlier quoted context omitted.

Unfortunately the recurrence rate after 1 year here is still quite high. Good progress, but not a cure yet.

Do cancers have a tendency to come back with better drug resistance if it's not fully eliminated? at least a resistance to the drug that got rid of it the previous time?

yes they are resistant to that line of therapy once it stops working.

Sometimes that resistance carries over to other lines too. For example, Enzalutamide doesn't work for prostate cancer if you were already treated by abiraterone.

Re: New treatment eliminates bladder cancer in 82% of patients

#88
post #8

My father currently suffers from bladder cancer, he's currently in palliative care, he's in Ukraine. If there are any medical professionals here, could someone provide an advice - is there any chance to get him access to TAR-200?

There are EU trials as well. Perhaps contact your physician, insurance or Johnson & Johnson directly.

https://euclinicaltrials.eu/ctis-public/view/2023-507685-10-...

To be honest, chances are slim to none. But worth a try.

Re: New treatment eliminates bladder cancer in 82% of patients

#89
post #73

Earlier quoted context omitted.

So sorry to hear this, I wish him the best.

No, the trial is closed to new participants. Check the company website to see if they are having international trials or are open to compassionate use.

Thank you.

Re: New treatment eliminates bladder cancer in 82% of patients

#90
post #8

My father currently suffers from bladder cancer, he's currently in palliative care, he's in Ukraine. If there are any medical professionals here, could someone provide an advice - is there any chance to get him access to TAR-200?

So sorry to hear this, I wish him the best.

Thank you.
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