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AlphaGenome: AI for better understanding the genome

deepmind.google

81–90 of 193 posts

Re: AlphaGenome: AI for better understanding the genome

#81
post #32

Earlier quoted context omitted.

Like Ballmer, he was set up for success by his predecessor(s), and didn't derail strong growth in existing businesses but made huge fumbles elsewhere. The question is, who is Google's Satya Nadella? Demis?

Since we're on the topic of Microsoft, I'm sure you'd agree that Satya has done a phenomenal job. If you look objectively, what is Satya's accomplishments? One word - Azure. Azure is #2, behind AWS because Satya's effective and strategic decisions. But that's it. The "vibes" for Microsoft has changed, but MS hasnt innovated at all. Satya looked like a genius last year with OpenAI partnership, but it is becoming incre…

People now days don't understand how genius MS was in the 90s.

Their strategy and execution was insanely good, and I doubt we'll ever see anything so comprehensive ever again.

1. Clear mission statement: A PC in very house.

2. A nationwide training + certification program for software engineers and system admins across all of Microsoft's tooling

3. Programming lessons in schools and community centers across the country to ensure kids got started using MS tooling first

4. Their developer operations divisions was an insane powerhouse, they had an army of in house technical writers creating some of the best documentation that has ever existed. Microsoft contracted out to real software engineering companies to create fully fledged demo apps to show off new technologies, these weren't hello world sample apps, they were real applications that had months of effort and testing put into them.

5. Because the internet wasn't a distribution platform yet, Microsoft mailed out huge binders of physical CDs with sample code, documentation, and dev editions of all their software.

6. Microsoft hired the top technical writers to write books on the top MS software stacks and SDKs.

7. Their internal test labs had thousands upon thousands of manual testers whose job was to run through manual tests of all the most popular software, dating back a decade+, ensuring it kept working with each new build of Windows.

8. Microsoft pressed PC OEMs to lower prices again and again. MS also put their weight behind standards like AC'97 to further drop costs.

9. Microsoft innovated relentlessly, from online gaming to smart TVs to tablets. Microsoft was an early entrant in a ton of fields. The first Windows tablet PC was in 1991! Microsoft tried to make smart TVs a thing before there was any content, or even wide spread internet adoption (oops). They created some of the first e-readers, the first multimedia PDAs, the first smart infotainment systems, and so on and so forth.

And they did all this with a far leaner team than what they have now!

(IIRC the Windows CE kernel team was less than a dozen people!)

Re: AlphaGenome: AI for better understanding the genome

#82

I wish there's some breakthrough in cell simulation that would allow us to create simulations that are similarly useful to molecular dynamics but feasible on modern supercomputers. Not being able to see what's happening inside cells seems like the main blocker to biological research.

I believe this is where quantum computing comes in but could be a decade out, but AI acceleration is hard to predict

Re: AlphaGenome: AI for better understanding the genome

#83

Earlier quoted context omitted.

He delivered revenue growth by enshittifying Goog's products. Gemini is catching up because Demis is a boss and TPUs are a real competitive advantage.

Demis reports to Sundar. All of Demis's decisions would have been vetted by and either approved, rejected, or refined by Sundar. There's no way to actually distinguish how much of the value was from whom, unless you have inside info.

The Nobel Committee seemed fairly sure who was responsible for what around those parts.

Re: AlphaGenome: AI for better understanding the genome

#85
post #81
post #32

Earlier quoted context omitted.

Since we're on the topic of Microsoft, I'm sure you'd agree that Satya has done a phenomenal job. If you look objectively, what is Satya's accomplishments? One word - Azure. Azure is #2, behind AWS because Satya's effective and strategic decisions. But that's it. The "vibes" for Microsoft has changed, but MS hasnt innovated at all. Satya looked like a genius last year with OpenAI partnership, but it is becoming incre…

People now days don't understand how genius MS was in the 90s. Their strategy and execution was insanely good, and I doubt we'll ever see anything so comprehensive ever again. 1. Clear mission statement: A PC in very house. 2. A nationwide training + certification program for software engineers and system admins across all of Microsoft's tooling 3. Programming lessons in schools and community centers across the count…

> some of the best documentation that has ever existed.

You have got to be kidding. The 90s was my heyday, and Microsoft documentation was extravagantly unhelpful, always.

Re: AlphaGenome: AI for better understanding the genome

#86
post #2

When I went to work at Google in 2008 I immediately advocated for spending significant resources on the biological sciences (this was well before DM started working on biology). I reasoned that Google had the data mangling and ML capabilities required to demonstrate world-leading results (and hopefully guide the way so other biologists could reproduce their techniques). We made some progress- we used exacycle to demo…

> Sundar is a really uninspiring leader I understand, but he made google a cash machine. Last quarter BEFORE he was CEO in 2015, google made a quarterly profit of around 3B. Q1 2025 was 35B. a 10x profit growth at this scale well, its unprecedented, the numbers are inspiring themselves, that's his job. He made mistakes sure, but he stuck to google's big gun, ads, and it paid off. The transition to AI started late but…

Tim Cook is the opposite of a hypeman.

Re: AlphaGenome: AI for better understanding the genome

#87

Naturally, the (AI-generated?) hero image doesn't properly render the major and minor grooves. :-)

Maybe they were depicting RNA? (probably not)

No; what they drew doesn't look like real DNA or (duplex double stranded) RNA. Both have differently sized/spaced grooves (see https://www.researchgate.net/profile/Matthew-Dunn-11/publica...).

At least they got the handedness right.

Re: AlphaGenome: AI for better understanding the genome

#88
post #81
post #32

Earlier quoted context omitted.

Since we're on the topic of Microsoft, I'm sure you'd agree that Satya has done a phenomenal job. If you look objectively, what is Satya's accomplishments? One word - Azure. Azure is #2, behind AWS because Satya's effective and strategic decisions. But that's it. The "vibes" for Microsoft has changed, but MS hasnt innovated at all. Satya looked like a genius last year with OpenAI partnership, but it is becoming incre…

People now days don't understand how genius MS was in the 90s. Their strategy and execution was insanely good, and I doubt we'll ever see anything so comprehensive ever again. 1. Clear mission statement: A PC in very house. 2. A nationwide training + certification program for software engineers and system admins across all of Microsoft's tooling 3. Programming lessons in schools and community centers across the count…

> the Windows CE kernel team was less than a dozen people!

It showed

CE was a dog and probably a big part of the reason Windows Phone failed. Migrating off of it was a huge distraction and prevented the app platform from being good for a long time. I was at Microsoft and worked on Silverlight for a bit back then.

Re: AlphaGenome: AI for better understanding the genome

#89

I don't think DM is the only lab doing high-impact AI applications research, but they really seem to punch above their weight in it. Why is that or is it just that they have better technical marketing for their work?

They have been at it for a long time and have a lot of resources courtesy of Google. Asking perplexity it says the alphafold 2 database took "several million GPU hours".

Re: AlphaGenome: AI for better understanding the genome

#90

Earlier quoted context omitted.

> Azure is #2, behind AWS because Satya's effective and strategic decisions I am going to have to disagree with this. Azure is number 2, because MS is number 1 in business software. Cloud is a very natural expansion for that market. They just had to build something that isn't horrible and the customers would have come crawling to MS.

You could just as easily make the argument that cloud is a very natural expansion for Google given their expertise in datacenters and cloud software infrastructure, but they are still behind. Satya absolutely deserves credit for Microsoft's success here.

I just listened to the Acquired podcast guys talk to Balmer. Steve actually deserves a huge amount of the credit for Azure that Satya enjoys today.

- Created the windows server product

- Created the "rent a server" business line

- Identified the need for a VM kernel and hired the right people

- Oversaw MSFT's build out of web services (MSN, Xbox Live, Bing) which gave them the distributed systems and uptime know-how

- Picked Satya to take over Azure, and then to succeed him

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