81–90 of 214 posts
Why not just lose weight by eating less? I know that sounds like a dumb question. But genuinely, aren’t you just paying money to… not spend the money on food instead?
Earlier quoted context omitted.
I have been on compounded GLP-1 for a month, prior to this I was a highly functional alcoholic, basically starting drinking after work every night and going until I passed out. I've drunk well over 50 beers (probably more) a week for the last 20 years. I have not had a drink since going on it. I have been reading obsessively about this drug since going on it. I have been fortunate enough not to suffer side effects on…
2.5mg?
Earlier quoted context omitted.
GLP-1 have already been on the mass market longer than Fen-Phen (7-years for Fen-Phen Vs. 15+ years, even just Semaglutide has been available longer than Fen-Phen now, and Semaglutide is a third-gen GLP-1). Honestly, this retort can be made about any/all new drugs entering the market. If you had a legitimate retort/critique I'm sure you would have presented it, but this is all we get. This is what happens when you st…
Ultimately the main reason it's bad right now is it's expensive. Far beyond the amount needed to recoup research investment and far far far far far far far far far beyond what it takes to synthesize. Low-end cost of $1000 a month is a lot. That's an expensive car lease, or half a cheap mortgage.
Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.
>> The number of things it apparently just cures is staggering. It cures behavior, not directly disease. I see red flags. Firefly did a movie about a drug that interfered with people's motivations to do things.
Nothing is being healed, we are just helping people cope with excess
Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.
I have been on compounded GLP-1 for a month, prior to this I was a highly functional alcoholic, basically starting drinking after work every night and going until I passed out. I've drunk well over 50 beers (probably more) a week for the last 20 years. I have not had a drink since going on it. I have been reading obsessively about this drug since going on it. I have been fortunate enough not to suffer side effects on…
There's the rub. We have not been prescribing semaglutide very long, and I won't trust it until we've had enough time to suss out long term side effects.
My father was on a long-term maintenance dose of immunosuppressant (I think prednisolone, but I could be misremembering) following his kidney transplant. When it was first prescribed to him, the long term side effects were either not known at all or not widely known. By the time these side effects were more widely known, it was too late, as he was already losing his vision (cataracts) and mobility (cartilage was being destroyed). He spent his last few years in pain.
I am very cautious about the potential for damaging long-term side effects.
Earlier quoted context omitted.
oh, so i guess you live outside and hunt animals for food? how's your all-natural neurochemical reward system?
If I'm not completely natural, then the entire population should have access to subsidized ozempic. Got it.
Earlier quoted context omitted.
There are multiple confounding factors: * Blood sugar levels (or whatever this is a proxy for) * Weight * The changes the GLP-1 Agonists make to the body itself. While it is simple to say if you reduce the weight, you reduce the blood sugar levels, and so the GLP-1 is unnecessary, you can look at many accounts of using Ozempic where it talks about reducing the "food noise." That is, Ozempic makes it easier to eat the…
I keep making the comparison to nicotine gum/patches, but for food. I'm hoping that such a simple analogy might help some people move past their innate biases, but not much traction so far.
According to this article, it's been (sorta) reproduced once, which is better than most studies. About 40-60% of scientific studies are not reproducible. Given that, I'd want to see more reproductions. Also, I'm very annoyed by our American culture which tries to fix problems with drugs, rather than preventing them from happening in the first place with good diet, exercise, sleep and stress management.
I agree with your sentiment, but frankly human nature just doesn’t work that way. We don’t have self control. We weren’t evolved for a world of abundance. This is no one’s fault, and it’s everywhere, china is getting fatter than most countries now. Realistically, ozempic is a miracle and it seems to be a solution to numerous issues of our world. It would be nice if it wasn’t so, but apart from the 10% of people who c…
Is it the ozempic or just the healthier weight / lower calorie intake?
So while it's an amazing drug / new class of drugs, it probably will not lower risk of Alzheimer's in metabolically healthy people.
Earlier quoted context omitted.
Gonna be fun discovering what side effects it causes in 20 years tho.
The real question is whether these side-effects are going to be worse than 20 years of not taking it.