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Anti-aging drug for dogs moves closer to gaining FDA approval

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Re: Anti-aging drug for dogs moves closer to gaining FDA approval

#81

Post by galleywest200 »

boppo1 wrote: post #63
ornornor wrote: post #59

Several vets have all told my parents to get mutts rather than purebreds because they have so much less problems. The genetics are just healthier and stronger because they’re a mix, instead of inbreeding for generations. Ditto for cats.

Good move unless it includes pit bull. Pitbull mixes are not appropriate for family pets and anyone who says otherwise is lying to you or themselves. Please protect your loved ones and stay away from pitbulls and pitbull mixes. They are total sweet hearts, right up until they're not. Edit: I too was once a 'how it's raised' apologist. After a number of experiences and some research, my mind is concluded. Someone in t…

Shelters will just not label the dog as a pitbull mix. I got a "border collie mix" that is indeed border collie but a DNA test shows it is part pitbull. Also part rhodesian ridgeback, part a bunch of other things.

Re: Anti-aging drug for dogs moves closer to gaining FDA approval

#82

Post by JumpCrisscross »

deadbabe wrote: post #2

Why would any creature have hormones to accelerate aging as opposed to just letting the body wear out naturally with use?

> Why would any creature have hormones to accelerate aging

Octopuses trigger rapid aging after giving birth from their “optic gland,” which “undergoes dramatic changes to produce more pregnenolone and progesterone, maternal cholestanoids, and 7-DHC during the stages of decline” [1]. (”Some females in captivity even seem to intentionally speed along the death spiral, banging into the sides of the tank, tearing off pieces of skin or eating the tips of their own tentacles” [2].) When the optic gland was removed, the affected females “abandoned their eggs, resumed feeding, and some even mated again.”

Leading theories include octopuses being “cannibals” having evolved “a biologically programmed death spiral may be a way to keep mothers from eating their young.” Alternatively, octopuses are close to biologically immortal, “so eliminating hungry adults keeps the octopus ecosystem from being dominated by a few massive” members.

TL; DR Programmed death is biologically precedents. There is evidence it is at work in most animals, including humans.

[1] https://news.uchicago.edu/story/what-causes-octopus-death-sp...

[2] https://www.sciencedaily.com/releases/2018/09/180925140402.h...

Re: Anti-aging drug for dogs moves closer to gaining FDA approval

#83

Post by google234123 »

hnbad wrote: post #71
boppo1 wrote: post #63

Earlier quoted context omitted.

Good move unless it includes pit bull. Pitbull mixes are not appropriate for family pets and anyone who says otherwise is lying to you or themselves. Please protect your loved ones and stay away from pitbulls and pitbull mixes. They are total sweet hearts, right up until they're not. Edit: I too was once a 'how it's raised' apologist. After a number of experiences and some research, my mind is concluded. Someone in t…

The problem with this widespread belief is that there is no such thing as a "pit bull". Or rather, there are many and some of the breeds are entirely unrelated. Likewise news stories are usually thin on the specifics and fail to identify exact breeds or may mislabel them entirely. Generally most people shouldn't have dogs because they lack the time and energy to properly train them (or in the case of adult dogs: to c…

Plenty of evidence against the Pit Bull Terrier type dogs. I can get you a dozen more studies

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597704/figure/... (bitten by a pit bull increased as the level of intervention increased from no repair (6.0%) to repair in the OR (25.8%))

https://www.dogsbite.org/dog-bite-statistics-multi-year-fata... 2/3rds of fatal attacks.

Re: Anti-aging drug for dogs moves closer to gaining FDA approval

#84

Post by cityofdelusion »

hnbad wrote: post #71
boppo1 wrote: post #63

Earlier quoted context omitted.

Good move unless it includes pit bull. Pitbull mixes are not appropriate for family pets and anyone who says otherwise is lying to you or themselves. Please protect your loved ones and stay away from pitbulls and pitbull mixes. They are total sweet hearts, right up until they're not. Edit: I too was once a 'how it's raised' apologist. After a number of experiences and some research, my mind is concluded. Someone in t…

The problem with this widespread belief is that there is no such thing as a "pit bull". Or rather, there are many and some of the breeds are entirely unrelated. Likewise news stories are usually thin on the specifics and fail to identify exact breeds or may mislabel them entirely. Generally most people shouldn't have dogs because they lack the time and energy to properly train them (or in the case of adult dogs: to c…

Not enough nuance in your comment. Shepherds are mouthy, bitey breeds as part of their bred disposition to herd -- they can draw blood and hurt infants, but they tend to have a "gentle" bite with their families -- they are strongly protective. Pits have a different lineage and a different neural pathway with their biting instincts.

Re: Anti-aging drug for dogs moves closer to gaining FDA approval

#85

Post by lukev »

boppo1 wrote: post #63
ornornor wrote: post #59

Several vets have all told my parents to get mutts rather than purebreds because they have so much less problems. The genetics are just healthier and stronger because they’re a mix, instead of inbreeding for generations. Ditto for cats.

Good move unless it includes pit bull. Pitbull mixes are not appropriate for family pets and anyone who says otherwise is lying to you or themselves. Please protect your loved ones and stay away from pitbulls and pitbull mixes. They are total sweet hearts, right up until they're not. Edit: I too was once a 'how it's raised' apologist. After a number of experiences and some research, my mind is concluded. Someone in t…

There is absolutely nothing wrong with a well trained and socialized pit bull/mix.

Anyone who says otherwise is lying to you or themselves.

EDIT:

None of the papers folks have posted control for training or socialization. I grant you that due to socioeconomic factors you will in fact find more samples of aggressive pitbulls than aggressive dogs of other breeds in most regions, but that is not what's under discussion.

They are a physically strong breed that is capable of lots of damage when not trained well, but that's true of many other breeds too. It's just less common (these days) to see abused or neglected german shepherds, rottweilers, sheepdogs, huskies, etc.

The video you posted is a sensationalist news story, not any kind of actual analysis.

Re: Anti-aging drug for dogs moves closer to gaining FDA approval

#86

Post by digging »

mikestew wrote: post #48
jurassicfoxy wrote: post #4

In addition, if anyone has an older dog, they should also immediately look into Librela: https://www.zoetisus.com/products/dogs/librela/ This is a miracle drug that pretty much instantly changed both my (older) dogs' lives. Every vet tech I've spoken to (it's a monthly injection) agrees it is amazing.

+1 on the Librela. "Fine, I'll blow $99 on your snake oil injection. Who knows, maybe it might actually work!" 36 hours later, the limping stops and the dog wants to walk further than he has in years. We take him to doggy daycare once a week since his housemate passed, and daycare staff commented on how he was like a new dog. Not every day is a great day, but most of them are.

I'm so happy to learn this exists, and I'm also feeling deep heartbreak that I didn't learn about it a year ago before we lost our dog. He had an almost inoperable tumor, so I don't know that we would've gotten a whole lot more time, but watching his decline and increasing pain was horrible. If we could've had even one more month of walks with him I would have paid a lot more than $99.

Re: Anti-aging drug for dogs moves closer to gaining FDA approval

#87

Post by boppo1 »

virgildotcodes wrote: post #41
balls187 wrote: post #40

Earlier quoted context omitted.

Until you’ve owned a Great Dane and see how much joy they bring you and your family, I don’t think you could understand why there is a desire to help their longevity.

Would a mutt have brought you and your family any less joy?

I think he just means 'large dog with particular temperament'.

I've had a few large dogs of various breeds and there is a wide spectrum.

Re: Anti-aging drug for dogs moves closer to gaining FDA approval

#88

Post by sergers »

ksoped wrote: post #3

Really wish this wasn't fox news ...

Google search shows this has been in the news from many outlets starting around Nov 29.

Thinking this was familiar, I saw it on local news tv on Nov 30

https://globalnews.ca/news/10139206/new-drug-big-dogs-longer...

Re: Anti-aging drug for dogs moves closer to gaining FDA approval

#89

Post by boppo1 »

google234123 wrote: post #83
hnbad wrote: post #71

Earlier quoted context omitted.

The problem with this widespread belief is that there is no such thing as a "pit bull". Or rather, there are many and some of the breeds are entirely unrelated. Likewise news stories are usually thin on the specifics and fail to identify exact breeds or may mislabel them entirely. Generally most people shouldn't have dogs because they lack the time and energy to properly train them (or in the case of adult dogs: to c…

Plenty of evidence against the Pit Bull Terrier type dogs. I can get you a dozen more studies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597704/figure/... (bitten by a pit bull increased as the level of intervention increased from no repair (6.0%) to repair in the OR (25.8%)) https://www.dogsbite.org/dog-bite-statistics-multi-year-fata... 2/3rds of fatal attacks.

Thank you, I don't have time to dig through my research folder at the moment.

Re: Anti-aging drug for dogs moves closer to gaining FDA approval

#90

Post by crashmat »

HEmanZ wrote: post #34
wiz21c wrote: post #31

After transhumanism, here comes transanimalism. I understand one may really like its dog/cat/... but, why not just accept time passes ? (I've lost a goldfish and I was not happy, proper burial helped a lot)

Comparing a family dog to a goldfish is such utter nonsense that you have to be a troll.

Humans can easily develop an emotional attachment to any living creature they care for, even things that aren't alive. Acting as if someone's emotional attachment to a creature is somehow invalid because it's not a creature people care about as often seems like more of the troll move here.
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