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Scientists discover links between Alzheimer's disease and gut microbiota

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Re: Scientists discover links between Alzheimer's disease and gut microbiota

#81
post #6

Earlier quoted context omitted.

For those that are curious and not well verse in research level biology, what kind of food, drink and lifestyle will help maintain a gut biome that prevent Alzheimer

Fatty fish, most nuts (that don't have high omega-6, which is inflammatory), fruits high in antioxidants like berries and dark fruit in general, colorful vegetable, cooking with olive/avocado/sunflower oil, *kefir* which is the champion of all good microbiota inducers As for avoiding : red meat (high in omega-6), gluten (chickpea, rice, lentil pasta instead of wheat), cooking with hydrogenated oils, preservatives, pr…

Most of this is conjecture though and should taken with a huge grain of salt (if we’re focusing on Alzheimers specifically)

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#82
post #6

I had to triple check the date because I was pretty sure that this was known before. Maybe it is simply the confirmation aspect of it? Edit: > Our findings reveal for the first time, that Alzheimer’s symptoms can be transferred to a healthy young organism via the gut microbiota, *confirming a causal role* of gut microbiota in Alzheimer’s disease ... From: https://faculty.sites.uci.edu/kimgreen/bio/glucocorticoids-a..…

For those that are curious and not well verse in research level biology, what kind of food, drink and lifestyle will help maintain a gut biome that prevent Alzheimer

I've been on a journey of hyper-optimisation of my nutrition for various goals (sport performance, health, intellectual performance, etc). Mediterranean diet seem to be the GOAT in most cases

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#83
post #6

I had to triple check the date because I was pretty sure that this was known before. Maybe it is simply the confirmation aspect of it? Edit: > Our findings reveal for the first time, that Alzheimer’s symptoms can be transferred to a healthy young organism via the gut microbiota, *confirming a causal role* of gut microbiota in Alzheimer’s disease ... From: https://faculty.sites.uci.edu/kimgreen/bio/glucocorticoids-a..…

For those that are curious and not well verse in research level biology, what kind of food, drink and lifestyle will help maintain a gut biome that prevent Alzheimer

This is impossible to say if you do not know your genetics. For example, being a FUT2 non-secretor will change everything about what you eat. Trust me, I am a FUT2 non-secretor. So in my case I need to eat a lot of seaweed and mushrooms which are both high in fucose (not fructose!).

https://journals.plos.org/plosone/article?id=10.1371/journal...

https://www.frontiersin.org/articles/10.3389/fnut.2020.60617...

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#84
post #6

Earlier quoted context omitted.

For those that are curious and not well verse in research level biology, what kind of food, drink and lifestyle will help maintain a gut biome that prevent Alzheimer

I've been on a journey of hyper-optimisation of my nutrition for various goals (sport performance, health, intellectual performance, etc). Mediterranean diet seem to be the GOAT in most cases

Unless you are Asian, or an Inuit.

Genetics matter. Eat like your great grandmother.

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#85

Earlier quoted context omitted.

I'm a fermentation freak so I have to highlight how uncooked fermented foods like sauerkraut and the aforementioned kefir play into anti-inflammation [0]. [0]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147091/

kimchi too?

yes. I had to heal my gut and kimchi and sauerkraut plus the occasional Kefir are great. I also take from time to time zinc L-carnosine and L-glutamine, great for the gut as well.

It's also a good idea to get tested for H Pilory.

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#86
post #60

Microbiome researcher here. As usual, when a microbiome paper reaches HN, I emerge to urge caution. You should be extremely skeptical of the larger conclusions drawn from this paper. The biology of Alzheimer's disease (AD) is poorly understood, and the contribution of dietary and microbiome factors are extremely unclear. I think you should treat the evidence from this paper (and shared in this thread) as more like "f…

Hey thanks for this info, all of which I'm sure is super insightful for people who understand this level of detail. What would you say the average person in the street should eat in terms of supplements, vitamins and food in general to maintain excellent microbiome based on your learnings?

[flagged]

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#87
post #60

Microbiome researcher here. As usual, when a microbiome paper reaches HN, I emerge to urge caution. You should be extremely skeptical of the larger conclusions drawn from this paper. The biology of Alzheimer's disease (AD) is poorly understood, and the contribution of dietary and microbiome factors are extremely unclear. I think you should treat the evidence from this paper (and shared in this thread) as more like "f…

As a micro biome researcher do you think I should be eating more kimchi?

[flagged]

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#88

Earlier quoted context omitted.

Fatty fish, most nuts (that don't have high omega-6, which is inflammatory), fruits high in antioxidants like berries and dark fruit in general, colorful vegetable, cooking with olive/avocado/sunflower oil, *kefir* which is the champion of all good microbiota inducers As for avoiding : red meat (high in omega-6), gluten (chickpea, rice, lentil pasta instead of wheat), cooking with hydrogenated oils, preservatives, pr…

I'm a fermentation freak so I have to highlight how uncooked fermented foods like sauerkraut and the aforementioned kefir play into anti-inflammation [0]. [0]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147091/

Sour red cherries are pretty good anti-inflamatory.

https://www.mcgill.ca/oss/article/food-health-you-asked/it-t...

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#89
post #42

Earlier quoted context omitted.

> You could sum up Alzheimer's as: Diet/Lifestyle + a congenital form of Cushing's syndrome and you have increasing glucocorticoids which imply downregulation of the PVN, Wit all else patients on GLP-1 agonists I wonder if the incidence of Alzheimer’s will decline? I wonder if Semaglutide reduces CRP? There are some preliminary indications that it may: https://cardiab.biomedcentral.com/articles/10.1186/s12933-02...

Between weight loss, inhibiting addictive behavior, lowering the risk of major cardiovascular events such as stroke, heart attack, and potentially derisking for Alzheimer’s, we should be pumping GLP-1 agonists out like a wartime effort. Likely contributor to fixing 70+ years of socioeconomic configuration that gave us Western Disease and the trimmings that come with it. https://www.bloomberg.com/news/features/2023-10…

T will be interesting to see the side effects of chronic use of these compounds. Still too early to know.
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