Mars is a very harsh environment - and it's very far from Earth (6 months best case with current propulsion technology). I'd suggest a permanent base on the Moon as a useful first step - it has some water, abundant energy, plenty of Aluminum, Magnesium, Titanium and a lack of atmosphere that makes metallurgy easy. Radiation is worse than Mars, but, in both cases, buried housing structures make sense and the Moon's lo…
His point was that the Moon can never be made habitable for humans, and the low gravity makes it hard to work.
The analogy he made was the Arctic--sure, it's a lot closer to Europe and Asia, but Columbus et al. went to the Americas instead. Farther away, but more habitable.