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Related recent discussions: A New Mode of Cancer Treatment - https://news.ycombinator.com/item?id=36982813 - Aug 2023 (205 comments) New targeted chemotherapy able to kill all solid tumors in preclinical research - https://news.ycombinator.com/item?id=36978199 - Aug 2023 (32 comments) 'Cancer-killing pill' is now being tested on humans - https://news.ycombinator.com/item?id=36969500 - Aug 2023 (33 comments) Cancer pi…
Earlier quoted context omitted.
Derek Lowe had a similar take: "AOH1996 is a very unremarkable-looking molecule - to be honest, it looks like the sort of stuff that you used to see in old combinatorial chemistry libraries in the late 90s and early 2000s, a couple of aryl-rich groups strung together with amide bonds." https://www.science.org/content/blog-post/new-mode-cancer-tr...
A key sentence: “I hope that human cancers will prove vulnerable to this new mode of attack in the clinic, and that they are not able to mutate around it with new forms of caPCNA too quickly, either.” Even if this does prove effective in humans, eventually cancer cell defenses will evolve to get around it.
The ABVD regime starts with the same baseline on all hodgkin's lymphoma patients, and 'cures' cancer permanently in quite a large number of them.
https://en.m.wikipedia.org/wiki/AOH1996 Look at that molecular structure. Incredible. Two amide bonds, a completely unremarkable aryl ether and an unsubstituted naphthalene ring system. No fussy weird metals or bonds that need pampering, no chiral carbon atom in sight. You could probably pay someone a very modest amount of money to end up with kilograms of this stuff, and it would probably not degrade at all under am…
> Look at that molecular structure. Incredible. Two amide bonds, a completely unremarkable aryl ether and an unsubstituted naphthalene ring system. Something about this delivery reminds of the business-card scene from Psycho [0]. > Look at that subtle off-white coloring, the tasteful thickness of it--Oh my God, it even has a watermark..." [0] https://www.youtube.com/watch?v=cISYzA36-ZY
Absolute clickbait fraudulent title. From the article in Cell: "Given orally, AOH1996 suppresses tumor growth but causes no discernable side effect" is a VERY different result.
You stop the cancer cell reproduction and overall tumor growth, you also kill the cancer.
Earlier quoted context omitted.
A key sentence: “I hope that human cancers will prove vulnerable to this new mode of attack in the clinic, and that they are not able to mutate around it with new forms of caPCNA too quickly, either.” Even if this does prove effective in humans, eventually cancer cell defenses will evolve to get around it.
I don't think that evolve is the right word here. It is not that cancers generally will develop to the point where this is no longer useful in humans. In a single human it is possible that some collection of cancer cells mutates in a way that makes them resistant or immune from this effect (e.g.: by not having the mutated PCNA), and so that strain will become the dominant cancer in that one person. It is also possibl…
Absolute clickbait fraudulent title. From the article in Cell: "Given orally, AOH1996 suppresses tumor growth but causes no discernable side effect" is a VERY different result.
https://www.science.org/content/blog-post/new-mode-cancer-tr...
Earlier quoted context omitted.
If it costs pennies a pill and you are trying to sell it for a million dollars, that is a surefire way to get murdered by a mob. I would just sell the patent to the government for a hefty profit and be done with it.
$100/vial insulin and $700 epi-pens would like a word. Thalidomide used to cost $6 per capsule in the '70s when it was given for morning sickness (yes, I know, birth defects) but as soon as they found out it cured cancer the price went up to $18,000 and that's on GoodRx lol. [1] Harvoni for Hep C is $94,500 for a 12-week course. Drugs aren't priced based on the cost to manufacture but based on the projected savings a…
https://en.m.wikipedia.org/wiki/AOH1996 Look at that molecular structure. Incredible. Two amide bonds, a completely unremarkable aryl ether and an unsubstituted naphthalene ring system. No fussy weird metals or bonds that need pampering, no chiral carbon atom in sight. You could probably pay someone a very modest amount of money to end up with kilograms of this stuff, and it would probably not degrade at all under am…
Derek Lowe had a similar take: "AOH1996 is a very unremarkable-looking molecule - to be honest, it looks like the sort of stuff that you used to see in old combinatorial chemistry libraries in the late 90s and early 2000s, a couple of aryl-rich groups strung together with amide bonds." https://www.science.org/content/blog-post/new-mode-cancer-tr...
[dupe]
You really think this twitter rando is the first source on this topic? Bunch more discussion over here: https://news.ycombinator.com/item?id=36982813 One of a number of posts over last few days