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Time-restricted eating reshapes gene expression throughout the body

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Re: Time-restricted eating reshapes gene expression throughout the body

#81

Post by QuarterReptile »

cycomanic wrote: post #39
mhaberl wrote: post #17

Earlier quoted context omitted.

yes, but only for a short time, usually 16-20h long fasts. Some people do fasts that last for multiple days, usually 3-7 days - this not I.F.

I have seen IF described as both in a day and in a week. Supposedly the effects are very similar as well.

In the most medical-establishment-adjacent space I could find in serious metabolic/longevity experimentation/ research, Peter Attia's podcast, the host talks about monthly 3-day fasts as an entering argument for decent garbage collection functioning (autophagy) that would potentially suppress/inhibit cancerous growth.

https://peterattiamd.com/ama13/

Re: Time-restricted eating reshapes gene expression throughout the body

#82

Post by wesapien »

sometimesno wrote: post #11
mrandish wrote: post #4

Notes: - In mice. - Tested 16:8 pattern. - Sustained consistently for nine weeks. - No exploration in this study of the effects and/or benefits from the gene expression. N=1 but I've been doing ~16:8-ish along with strict keto for the past five years and the net benefits for me have been transformative in fitness (Weight: -100+ lbs, BMI: Obese->Fit), long-term health (A1C, LDL/HDL, Trigs, BP, resting heart rate all f…

16:8 is utterly unremarkable. A huge percent of people skip breakfast and then have dinner before 8pm. This is a normal, bog standard eating pattern.

That's the thing. Most people would greatly benefit from the unremarkable lifestyle change but a lot of people cannot do it due to reasons and a safety net.

Re: Time-restricted eating reshapes gene expression throughout the body

#83

Post by zargon »

sidcool wrote: post #10

Does restricted time eating mean intermittent fasting?

A lot of people (including me in the past) have used the term intermittent fasting to describe this, but it's not a good label for this. Intermittent fasting should describe protocols where one fasts for at least a full day. If one is eating daily but only during certain hours, it's better described as time-resricted eating. It's also possible to do both time-restricted eating and intermittent fasting.

Re: Time-restricted eating reshapes gene expression throughout the body

#84

Post by spirit557 »

torusenthusiast wrote: post #70

For posters who do time restricted eating, how do you deal with the panicked/dizzy feeling you often get when not eating for long periods. Does that eventually go away with IF, or do you just get used to it?

That's from low blood pressure and/or electrolyte imbalance. So drink more fluid supplemented with electrolytes. You can also take a spoonful of a pure fat like coconut oil or ghee in the morning or in between a meal to help with any hunger pain.

You don't faint from low blood sugar, you faint from low blood pressure. If you were losing consciousness from low blood sugar you're gong to start convulsing and having seizures, afaik.

In normal homeostasis, insulin lowers blood sugar as needed and glucagon raises it. There is always a balance being made between the two I believe.

Re: Time-restricted eating reshapes gene expression throughout the body

#85

Post by kayoone »

layer8 wrote: post #69
kayoone wrote: post #12

Earlier quoted context omitted.

I had similar improvements without fasting and without keto. I do 16:8 on some days but it's mostly to help me manage my weight. I strongly believe most of the fasting benefits come from the fact that it makes managing weight easier. Calorie restriction and tracking my macros has helped me tremendously not only loosing weight but also understanding nutrition and what works for me and what doesn't. I am a 40 year old…

> it also tanked my hormone levels. How do you measure those?

with blood work, I had some symptoms as increased fatigue, libido gone and similar which can also come from extended calorie restriction together with intense excercise anyway, so its not necessarly keto related.

Re: Time-restricted eating reshapes gene expression throughout the body

#86

Post by makeitup1818w1 »

piqi wrote: post #37
snozolli wrote: post #28

Earlier quoted context omitted.

In my experience, it's exceptional in America. This may be due to constant indoctrination that "breakfast is the most important meal of the day". Also, modern food processing has put all sorts of late-night snacks at our fingertips.

Hard to imagine skipping breakfast, lunch, coffee/tea w/milk & cream, and all snacking during the day, everyday is normal outside America. Isn't burned bread with beans or butter for breakfast a thing in the UK? 16:8 means if your last calories are before 10PM, you wouldn't eat anything at all until after 2 PM. And this would be every day, not every other day. 12:12 might be more common, but not consistently.

It’s more common in parts Europe than you’d think I guess, with the last calories around 8-9pm until 1pm (or 11pm until 3pm a bit southwest of here) there are variants around that of course and I’m less sure how common this is everywhere in Europe, but where I’ve lived a lot of us eat like that. It’s not some fad just a long held habit, not sure where it came from or why so many of us seem to do it here.

That said, it is changing by the day and I see more teenagers snacking at odd times.

Re: Time-restricted eating reshapes gene expression throughout the body

#87

Post by bongoman37 »

wpietri wrote: post #52
andy_ppp wrote: post #50

Earlier quoted context omitted.

No, that is not my theory. How similar is 16:8 for mice and humans? That’s all we are discussing here and all I’ve talked about! I’ve reread my comments and I really can’t see where I start talking about all biological similarities or not. I’m talking specifically about 16:8 fasting. Can you tell me how similar humans and mice are in this regard?

Ok, so your theory is that even though we study mice because the are in many ways good proxies for humans, there's some special exception when it comes to fasting? Yes, we don't yet know precisely how similar humans and mice are in this regard, because studies in mice generally precede doing the matching study in humans. But that doesn't mean we should assume that there's absolutely no correlation. And yes, the more…

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Re: Time-restricted eating reshapes gene expression throughout the body

#88

Post by sidcool »

SavageBeast wrote: post #15
sidcool wrote: post #10

Does restricted time eating mean intermittent fasting?

Presuming you read the linked study but more or less (and this is argument fuel among The Faithful here ), "time restricted eating" spoken of here is Intermittent Fasting. The "restriction" here is that not a single calorie of anything is consumed outside of an 8 hour window and the 16 remaining hours in the day are nothing but water. Some people even like to do a 18:6 split too. The hacks in this style of eating is…

Thanks for the detailed response. Are the advantages of fasting well researched?

Re: Time-restricted eating reshapes gene expression throughout the body

#89

Post by moremetadata »

StefanWestfal wrote: post #32
pammf wrote: post #14

I’ve been doing intermittent fasting for 2 years. Did a bunch of different protocols and eventually settled on ~18:6. Lost around 15kgs (from 105 to 90) and as a nice “side effect” got rid of all skin problems that I’d had during the previous 10 years or so. Today I don’t preach it anymore cause I got tired of debating whether it was healthy or not but I definitely recommend to everyone that’s truly interested in giv…

I tried it for some time but felt cranky in the morning until I ate at lunch time. How was your experience regarding cravings, hunger and mood changes over time when starting your fasting?

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Re: Time-restricted eating reshapes gene expression throughout the body

#90

Post by eganist »

galangalalgol wrote: post #58
kayoone wrote: post #12

Earlier quoted context omitted.

I had similar improvements without fasting and without keto. I do 16:8 on some days but it's mostly to help me manage my weight. I strongly believe most of the fasting benefits come from the fact that it makes managing weight easier. Calorie restriction and tracking my macros has helped me tremendously not only loosing weight but also understanding nutrition and what works for me and what doesn't. I am a 40 year old…

For me the benefits seem to be a lack of carb cravings, and my fullness indicator turned on for the first time in my life. That was with 20:4 though, and no keto.

I've been doing this since January 1. 18:6 with full keto (as close to 0g carbs as possible with no sweeteners of any kind) and I feel full.

I've never felt full.

I cried when I realized it. I'm down 30lbs so far.

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