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Fentanyl vaccine tested in rats

uh.edu

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Re: Fentanyl vaccine tested in rats

#82

Earlier quoted context omitted.

> Something like this happened in neuromancer. Right, and Case bought betaphenethylamine instead of speed which was way harsher. That's exactly what is going to happen, some more potent drug that escapes the vaccine is going to get more popular. It's a bandaid solution that ignores the root cause (drug prohibition)

Wait, what? Selling fentanyl as candy in every street corner shop is going to fix this?

Yeah. Since alcohol became legal nobody has died from it.

Re: Fentanyl vaccine tested in rats

#83
Nothing wrong with this being on the front page. Just posting this here as a question. Is the reason why this is on the front page because a good number of software engineers addicted? Maybe you don't have the numbers but you yourself who's reading this may be personally interested in a vaccine?

Re: Fentanyl vaccine tested in rats

#85
post #83

Nothing wrong with this being on the front page. Just posting this here as a question. Is the reason why this is on the front page because a good number of software engineers addicted? Maybe you don't have the numbers but you yourself who's reading this may be personally interested in a vaccine?

I think it’s more about interest in the system, threat and the mitigation. The technical nature of biochemistry attracts many to this forum. Biohackers if you will.

Re: Fentanyl vaccine tested in rats

#86
post #53

Oh boy, the pharmaceutical companies can sell a new product to help solve the mess that one of their previous products created. An opioid that's more potent, more addictive, and more deadly than heroin should never have gone to market in the first place. It speaks of enormous corruption and a complete lack of ethics when regulators didn't see an issue with fentanyl and let it move forward. The "but people are in pain…

> An opioid that's more potent, more addictive, and more deadly than heroin should never have gone to market in the first place.

This is a little misplaced. Fentanyl is a medically useful drug. Fentanyl had years of use as an anesthetic agent (and still does - it is an essential ICU medication) before the idea of marketing it for other purposes occurred.

And without defending the pharma industry and their role one bit. The vast majority of fentanyl these days is not from big pharma, and it's arguable what relative role fentanyl played vs all the other drugs

Specifically, the demand for illegitimate fentanyl today was mostly driven due to addictions from other medications that were NOT fentanyl - such as oxy, hydrocodone and even the "safe" tramadol.

Having said that, it's going to be a hard sell that all opioids should be banned. There is some middle ground between reserving for palliative and acute critical illness and having PCPs prescribe for simple back pain.

> heroin is safer

It is a smidge more complex. Fentanyl has some pharmacologic properties that make it safer for controlled use in sick patients. Heroin has similar metabolite related side effects as morphine.

Re: Fentanyl vaccine tested in rats

#87
post #83

Nothing wrong with this being on the front page. Just posting this here as a question. Is the reason why this is on the front page because a good number of software engineers addicted? Maybe you don't have the numbers but you yourself who's reading this may be personally interested in a vaccine?

Hacker News is for any kind of intellectual curiosity. It’s right there in the community guidelines.

And who knows, maybe this bit of creative immune system hacking will inspire a security researcher.

Re: Fentanyl vaccine tested in rats

#88

Or just make fentanyl very hard to prescribe? We are getting dumber by the minute.

nearly all the fentanyl on the street is illegally manufactured, not diverted from prescriptions.

fentanyl is ideal for smuggling because of how potent it is, and ideal for clandestine manufacture because it doesn't require opium as a starting material.

Re: Fentanyl vaccine tested in rats

#90
post #72

Earlier quoted context omitted.

Wegovy?

Will it stop me getting high on food? If so, it's a blessing.

I believe so. But do please recall that your consciousness supervenes on a maschine made of meat, and spent several billion years wiring itself to get a dopamine hit from, yes, nutrients.

It's called walking the gradient ;D There's no cure, alas, for being a neural network

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