81–90 of 364 posts
Earlier quoted context omitted.
Studies have shown the common (LFIA) antibody tests administered to most people have specificity <50%
Which ones? I'm looking at this page and am seeing numbers in the high 90's https://www.fda.gov/medical-devices/coronavirus-disease-2019...
Can someone tell me why we (US) don't have a vaccine passport yet?
What problem does a domestic vaccine passport solve?
This is great news, adding to a report in Nature that the natural immunity produced in people who have already had covid may last a lifetime.[1] In case you hadn't heard, the Cleveland Clinic--consistently regarded as one of the top hospital systems in the United States and in the world--recently shared a study of 52,238 patients showing zero incremental benefit from the jab to the previously infected, recommending t…
This study ended May 15, 2021, and it notes that:
>Lastly, it is necessary to emphasize that these findings are based on the prevailing assortment of virus variants in the community during the study. It is not known how well these results will hold if or when some of the newer variants of concern become prominent.
Another study found that, for people already seropositive for SARS-CoV-2 antibodies from a previous infection, getting the first dose of an mRNA vaccine increased antibody titers by two orders of magnitude on average [1] but that the 2nd dose had no effect on antibody titers.
[1] Florian Krammer, et al. "Antibody responses in seropositive persons after a single dose of SARS-CoV-2 mRNA vaccine." New England Journal of Medicine (2021). https://www.nejm.org/doi/full/10.1056/NEJMc2101667
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But the issue, is that if you had your first dose 2 days before being infected, you count as being infected after 1 dose. We need to compare "1 dose, x days after first dose" and "two doses, x days after first dose" to compare the same thing
That is not consistent with the "Vaccination status" definition in the paper I cited. The tl;dr on that is that "first dose" starts 21 days after vaccination, and "second dose" 14 days after. Also, to get a better sense of the timeline for vaccination effectiveness, take a look at a chart like this one: https://www.technologyreview.com/2020/12/10/1013914/pfizer-b...
We need something like, 21 days after the first dose, and split the result between people who got one dose and those who got two. We also need to make sure that the repartition of ` age since first dose` is the same for the two doses group and the single dose group.
Has there been any work done on the severity of the COVID 19 variants? My understanding is variants of highly dangerous viruses rarely keep the high level of risk as the progenitors. Does the delta variant and others pose the same risks? Are we over responding to a virus family group?
> My understanding is variants of highly dangerous viruses rarely keep the high level of risk as the progenitors.
Even if that's a general trend that doesn't mean it's a rule. And the rationale "a dead host isn't as useful at spreading the virus" doesn't really apply to covid since only a small percentage gets hospitalized or dies, most infectees remain fit enough to spread it further.
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Good antibody tests are extremely (99%) accurate in verifying previous infection, not sure why you're claiming the opposite...? And while vaccination is safe and easy to get , both me and a lot of my friends were basically as sick as a regular flu for a day or two from it. Some people have no reaction, which is wonderful, but a lot of people need to take a sick day or two, or intentionally get the vaccine on a Friday…
What is the population of people who are willing to get a blood draw for an accurate antibody test but haven’t been vaccinated already and can’t afford moderate flu-like symptoms for a day? I’m sure a small number of people like that exist but it’s not really worth carving out complex exceptions to vaccination rules (specifying which kind of antibody tests administered by who and when, etc.) to accommodate their pref…
First you claimed antibody tests are inaccurate, which is totally false.
Now you're worrying that there are too many antibody tests...? Just like there are 3 vaccines, at least in NYC there are/were only 3 or 4 main antibody tests administered by the city.
It's super easy. Basically nobody's anti-antibody test the way there are anti-vaxxers, so it's actually a significant proportion of the population. And you know what? Being sick and useless for a day or two is actually a big impact on people's lives, I don't know why you're so uncaring.
It would obviously be beneficial if the commonly recognized antibody tests carried the same weight as a vaccine card, i.e. an equivalent standardized "antibody card".
The mRNA vaccines have been the silver lining to the whole COVID-19 disaster. They seem “unreasonably effective” against COVID, basically if you had a genie that you could ask to make a vaccine, it would be hard to do much better, other than the requirement for 2 jabs. In addition, the mRNA technology has broad applicability to other issues such as other viruses (such as flu) and even cancer!
Does mixing of one mRNA vaccine with another mRNA vaccine for the second does create the same effect as if it's one brand of vaccine was used?
"Follow up earlier post. Here is moderna/pfizer/wild type spike. There is only 2 amino acids different from wild to vaccine. Same for both vaccines. The change forces the protein to look like it would when stuck to the outside of the virus, without needing the rest of the virus"
From Thought Emporium on twitter (cool biohacker with particular focus on genetic engineering, but amazing breadth into physical sciences as well - I highly recommend his youtube channel)
https://twitter.com/EmporiumThought/status/14081777241920675...
Can someone tell me why we (US) don't have a vaccine passport yet?
A centralized database that is used to control individuals is akin to China's social credit system. I've actually started seeing people argue for China style systems, and I find it both frightening and sickening.
When I start to push back at all, I usually get arguments like `Leave the US if you don't like it.`, and sure I'll just pick up and leave the country I was born in, but beyond that where will I be able to go?
If I just want my own individual rights, where in the world will I be able to go if what is basically the last bastion of freedom and individualism is lost to tyrannical majority rule?
Moreover, Pfizer is partner of BioNTech, which developed the vaccine. I don’t understand why OP omits that and solely credits Pfizer.
Earlier quoted context omitted.
Which ones? I'm looking at this page and am seeing numbers in the high 90's https://www.fda.gov/medical-devices/coronavirus-disease-2019...
Those are not LFIA tests