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Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

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Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#81

Post by nefitty »

throw_this_one wrote: post #79
__blockcipher__ wrote: post #61

Earlier quoted context omitted.

I accidentally dosed myself in the middle of the night once after turning LSD crystal into ethanol:water:lsd solution and being careless at some point in the process. Those damn mucous membranes, they really get ya. Must have touched my lips absentmindedly. Before I realized, I was in bed trying to sleep. Restless, tossing and turning. Eventually started feeling that unmistakable body high around 1am. Anyone who’s do…

Would you recommend a full dose 125-175ish by yourself for the first time?

You’ll reduce your risk of freaking out if you have a trip sitter or if you work your way up to that point over time.

Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#82

Post by nefitty »

almostdeadguy wrote: post #32
throwaway5938 wrote: post #6

Earlier quoted context omitted.

Please, you're on a discussion site where the main demographic is actively microdosing to improve their productivity at startups inbetween two editions of Burning Man. You'd be hardpressed to find someone without a first-hand experience of acid. But yeah, you pretty much tend to remember everything that happens to you during a trip, even years afterwards, which naively makes me believe your brain and memories become…

Utterly pretentious, dweeby reason to take acid

Different folks have different goals. There’s nothing inherent about any chemical or tool.

Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#83

Post by evo_9 »

Enginerrrd wrote: post #69
bb88 wrote: post #66

Earlier quoted context omitted.

It is also true that when we could have been exploring psychedelics back in the 60/70's, but they were made illegal mostly as a political backlash to the counterculture -- thus pretty much stifling the last 50 years of research on them. "Punching-the-hippy" politics aside, the political leaders told us there was nothing beneficial ever about those drugs, and we typically believed them, even lumping scientists who wan…

Honestly a fair number of studies have been done and the problem with all that stuff is there's always been a relatively high rate of complications and adverse outcomes. Responses/experiences are hard to predict. I get that in some people it can be a wonderful thing, nearly a miracle cure. I've done plenty of psychedelics myself, but I always find the insistence by proponents that any harm done is the fault of the us…

I don't disagree with this; I do wonder however if this is more related to the black-market nature of this drug. Aka, inconsistent 'manufacturing' processes, etc. Meaning if it were legal and had a process in place to assure the correct chemical composition, if that would still happen.

Thinking about this further - have bad trips been observed in clinical studies where the the LSD was created in a controlled, ideal lab setting?

Would be interesting to know if this was or wasn't the case; could indicate a bad trip is an unavoidable potential side-effect, or if it is a specific reaction to poorly created LSD.

Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#84

Post by nix23 »

aaronharder wrote: post #54
nix23 wrote: post #21

Earlier quoted context omitted.

Or maybe it's the other way around.

Incorrect and vulnerable crypto is why people are microdosing LSD?

Maybe that too, we will never know it. Or maybe you just can write good crypto if your on LSD, just look at the best OS and where it was ~developed...Berkeley :)

Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#85

Post by nurettin »

nicoffeine wrote: post #46

Low doses may also prevent Alzheimers from progressing.[1][2] Ayahuasca/DMT[3] and psilocybin[4] may have similar effects. It's fascinating that a monthly visit to your local shaman may still be more safe and effective for depression, anxiety, and cognitive decline than anything western medicine has been able to produce. [1] https://www.forbes.com/sites/abbierosner/2020/02/21/microdos... [2] https://www.ncbi.nlm.nih.…

visit to your psychiatrist will get you addicted to ritalin and valium. Visit to your local shaman will get you addicted to acid and shrooms. Your local dealer will get you addicted to meth, heroine and coke. Your choice.

[https://omitted.useless.links]

Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#86

Post by ashtonkem »

nurettin wrote: post #85
nicoffeine wrote: post #46

Low doses may also prevent Alzheimers from progressing.[1][2] Ayahuasca/DMT[3] and psilocybin[4] may have similar effects. It's fascinating that a monthly visit to your local shaman may still be more safe and effective for depression, anxiety, and cognitive decline than anything western medicine has been able to produce. [1] https://www.forbes.com/sites/abbierosner/2020/02/21/microdos... [2] https://www.ncbi.nlm.nih.…

visit to your psychiatrist will get you addicted to ritalin and valium. Visit to your local shaman will get you addicted to acid and shrooms. Your local dealer will get you addicted to meth, heroine and coke. Your choice. [ https://omitted.useless.links ]

Claiming that acid or shrooms is addictive like heroine or cocaine is a big “Citation Needed” moment.

Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#87

Post by __blockcipher__ »

throw_this_one wrote: post #79
__blockcipher__ wrote: post #61

Earlier quoted context omitted.

I accidentally dosed myself in the middle of the night once after turning LSD crystal into ethanol:water:lsd solution and being careless at some point in the process. Those damn mucous membranes, they really get ya. Must have touched my lips absentmindedly. Before I realized, I was in bed trying to sleep. Restless, tossing and turning. Eventually started feeling that unmistakable body high around 1am. Anyone who’s do…

Would you recommend a full dose 125-175ish by yourself for the first time?

If it's truly pure LSD, 100ug is plenty. Many hits sold as 100ug really aren't.

That being said, you are more likely to be fine than not on 125ug-175ug, but responses are really variable. I've discovered that I'm very steady on psychedelics and so I can handle physical discomfort (jitteriness etc) and not have a bad time, but there's a certain archetype of individual that has trouble handling the raw barrage of stimulus that tripping represents.

So, you would probably be okay but I would recommend no more than 100ug taken in a natural setting (rather than being stuck inside your house).

Cheers.

Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#88

Post by __blockcipher__ »

nefitty wrote: post #81
throw_this_one wrote: post #79

Earlier quoted context omitted.

Would you recommend a full dose 125-175ish by yourself for the first time?

You’ll reduce your risk of freaking out if you have a trip sitter or if you work your way up to that point over time.

This, although some caveats:

(1) Be careful who you choose as a trip sitter. Some people are really bad at it and just end up being super annoying because they're staring at you like you're a zoo animal and keep asking you if you "see colors". Which is a long way of saying, make sure your trip sitter has actually taken psychedelics before, the utility of bringing a sober person along just because they're sober if they don't have psychedelic experience is quite low. (There are some individuals that have never done drugs yet still "get it" so I'm not talking about them to be clear)

(2) Working up doses over time is very good advice, most bad experiences are a result of taking too much in the wrong environment, and/or neglecting the basics. I've found 90% of trip discomfort is solved with water, a blanket, or changing up your physical environment.

But it is worth mentioning that accidentally taking a heavier dose because you think it's a normal dose - can sometimes work out, in the sense that once you've taken, say, 2.5g of shrooms you can't imagine taking 3.5g. I've noticed this particularly with DMT, if you don't get absolutely blasted it's easy to get anchored and be afraid to really commit to a breakthrough experience (as much as I hate the duality / binarity of the whole "breakthrough" concept there's definitely some truth to it)

So: taking a heavy dose as nooby is a terrible idea and thus I never recommend it. But sometimes the terrible idea works out in your favor :)

Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#89

Post by saiya-jin »

evo_9 wrote: post #83
Enginerrrd wrote: post #69

Earlier quoted context omitted.

Honestly a fair number of studies have been done and the problem with all that stuff is there's always been a relatively high rate of complications and adverse outcomes. Responses/experiences are hard to predict. I get that in some people it can be a wonderful thing, nearly a miracle cure. I've done plenty of psychedelics myself, but I always find the insistence by proponents that any harm done is the fault of the us…

I don't disagree with this; I do wonder however if this is more related to the black-market nature of this drug. Aka, inconsistent 'manufacturing' processes, etc. Meaning if it were legal and had a process in place to assure the correct chemical composition, if that would still happen. Thinking about this further - have bad trips been observed in clinical studies where the the LSD was created in a controlled, ideal l…

I've seen really bad trips from literally just weed, the same I smoked and was as A-OK as possible. I mean really bad stuff, like blood flowing down the walls around us, they are coming for us panick etc.

Its not the substance purity, but some people are a mess, and sometimes they don't realize/admit it. Some become mess with frequent use. Those definitely shouldn't play with stronger stuff, whatever that is for them.

Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#90

Post by saiya-jin »

stupidcar wrote: post #36
iamgopal wrote: post #2

Anyone with first hand experience of LSD ?

I used it at a birthday party a few years ago. My main takeaways were twofold: First, it made me understand the concept of good and bad "vibes" w.r.t. to drug use. It was clear that the experience of taking LSD recreationally in a group of people was a much a social experience as a chemical one. Keeping the "vibe" positive, by playing the right kind of music, staying chill, and saying and doing the right things, was…

I had those experiences repeatedly (shrooms, which should be +-same), but always alone. I can't imagine doing that journey with anybody else, even close girlfriend, it would be just negative interference and distractions. In fact, I lost all my regular senses, laying on the bed, listening to very nice shamanic music (that must have helped a bit). I understood where religion comes from, or so it seemed to me at that time. At the end of the trip I had spiritual experience without any classical presence of god, at the end just chemicals going haywire in my brain.

By huge margin consistently the most intense experience in my life, and I've been through some stuff (birth of my son, 6 months backpacking in Himalaya, adrenaline/mountain sports, not in that order).

That was some 10 years ago, I don't even feel the need to try again. Kind of lesson took, not much more to gain, only risking some bad drama.

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