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Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

diabetes.co.uk

81–90 of 148 posts

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#81
post #4

I was on a low-carb diet for a while. Loved it. Felt great. Was totally fit. All my digestive problems cleared up. I would never get "hangry". By every single subjective measure my quality of life and sense of well-being improved. Then I got my cholesterol checked during a routine blood work and it was through the roof. WTF? Anyone know better than me about this?

There is an incredible amount of confusion surrounding cholesterol, mostly because of the incredible amount of bad/old/incomplete science around which many major medical associations base their recommendations.

To put it simply, using "cholesterol" as an indicator for anything is a completely oversimplified view originating in the 50s, when we didn't know enough molecular biology to know better. We've since moved on to breaking out LDL (bad) and HDL (good) cholesterol. However, as it turns out even that is too simplistic. There are further sub-classifications of LDL, such as large fluffy LDL and small dense LDL. If subclasifying LDL - Low-Density Lipoprotein - as "small and dense" seems counterintuitive, I agree. I feel like it's a result of the order in which we learned about all the forms of cholesterol, and a reflection of how complex the system is, and perhaps how much more we have left to fully understand it. As it turns out, so many of the perils of what we thought was caused by "high cholesterol", and then "high LDL/bad cholesterol" seem to be most strongly correlated with the small/dense LDL pattern. The irony is, we've been measuring everything but the main culprits, gaining an incomplete picture of what's actually going on, then ended up with wildly ineffective or harmful dietary recommendations as a result. A low fat high carb diet may reduce your cholesterol, but it can wreak havoc in so many other ways.

Bottom line is, eating a low carb, high fat diet increases all of your cholesterol (subject to individual variation), but seems to exert favorable effects on the overall ratio of the individual particles, which may be the important thing. If you're really interested in what's going on with your cholesterol, ask for a LDL particle size test, then you may be able to draw some more meaningful inferences. [1]

To me, it's a good hint that if every physical and mental aspect of your body improved on a diet, it's unlikely a bad thing. Best to discuss these things with your doctor though. Diet science is still a frustratingly murky field, so it's pretty hard to navigate right now. If you want to understand why, I highly recommend Good Calories, Bad Calories by Gary Taubes.

[1] http://education.questdiagnostics.com/faq/FAQ134

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#82

Earlier quoted context omitted.

so. this is so general that it’s not helpful. what ranges are we talking about? also, when people talk about cholesterol they usually don’t mean cholesterol they mean lipi-proteins that carry the cholesterol through the blood (cholesterol needs this as it’s hydrophobic). LDL from those lipo-proteins is definitely correlated with heart disease. Here, read about it in more detail than you probably need to know: https:/…

LDL is correlated but not causative and it's been discovered that HDL is a much better indicator. Take a look at this book: https://www.amazon.com/Big-Fat-Surprise-Butter-Healthy/dp/14... It goes into it quite a bit more -- cholesterol is a _terrible_ indicator of overall health. This is well known in the Keto community.

when you use LDL, HDL and cholesterol interchangeably this tells me that you don’t know what you’re talking about. Cholesterol itself is part of the lipid membrane of every cell. It’s essential. When people say “high cholesterol” they usually talk about high cholesterol carrying lipo-proteins in the bloodstream. high ldl is definitely a risk factor for CHD

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#83

I'm a type 1 diabetic and find these articles and studies frustrating. Or at least the way people interpret them. > Two weeks after adopting the low carb approach insulin was no longer needed. After 18 months insulin therapy was once again required at low doses of around 16 units per day. HbA1c remained very well controlled on the LCHF diet with insulin. So during the honeymoon period, he was able to live without ins…

Here is the actual study [1]. This is n=3, so we are talking about highly anecdotal data. Nonetheless, I think this statement is misplaced: > Low carb diets can help type 1 diabetics, but it's not a cure Likely, as in most cases, the real picture is much more complex. It could be the case that LCHF diets can cure some percentage of individuals, can help some percentage and can be detrimental perhaps even fatal to som…

It's well understood that insulin production in type 1 diabetics can continue at low levels for ~5 years post-diagnosis; the process of beta cell destruction is a gradual one and diagnosis typically occurs after 80-90% of beta cells function has been lost.

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#84
What is this “remission” for type-2 diabetes? Does it mean that someone with the condition can, after adhering to the diet for some time, then go back to eating how they used to?

I don’t think so, so “remission” is bogus. The symptoms can be controlled with diet, but you have to stay on the diet.

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#85
post #4

I was on a low-carb diet for a while. Loved it. Felt great. Was totally fit. All my digestive problems cleared up. I would never get "hangry". By every single subjective measure my quality of life and sense of well-being improved. Then I got my cholesterol checked during a routine blood work and it was through the roof. WTF? Anyone know better than me about this?

> Then I got my cholesterol checked during a routine blood work and it was through the roof. WTF? Anyone know better than me about this?

This is not necessarily a bad sign, but you should talk to your doctor about getting more advanced cholesterol blood tests.

There are different measures of cholesterol, like concentration per particle, number of particles, and size of particles, and regular bloodwork usually only measures one of those (concentration, I believe).

You can have a lot of small, empty particles, or fewer large, dense particles, and so forth. This means a regular test may not paint the whole picture, especially if you’re doing something “non-standard” like a keto diet, fasting, or if you’re losing significant body fat.

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#86

I'm a type 1 diabetic and find these articles and studies frustrating. Or at least the way people interpret them. > Two weeks after adopting the low carb approach insulin was no longer needed. After 18 months insulin therapy was once again required at low doses of around 16 units per day. HbA1c remained very well controlled on the LCHF diet with insulin. So during the honeymoon period, he was able to live without ins…

Hugely reducing insulin dosing is still probably valuable, especially for Americans since it's so expensive.

[deleted]

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#87
Reiterating what the diabetics in these threads will tell you:

Type 1 isn't about insulin resistance in your cells, it's about not producing insulin in your pancreas. Of course type 1 diabetics with rigorous diets will have less glucose swings, but a stable A1c or daily tests doesn't mean your eyelet cells grew back. It's a bit like saying a hemophiliac is asymptotic because they haven't had any cuts lately.

These kinds of articles can come off as callus to diabetics. They're getting diet advice from their GPs and their endocrinologists. They don't need muggles telling them to eat better.

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#88
post #4

I was on a low-carb diet for a while. Loved it. Felt great. Was totally fit. All my digestive problems cleared up. I would never get "hangry". By every single subjective measure my quality of life and sense of well-being improved. Then I got my cholesterol checked during a routine blood work and it was through the roof. WTF? Anyone know better than me about this?

>Then I got my cholesterol checked during a routine blood work and it was through the roof. WTF? Anyone know better than me about this?

Your LDL(bad), HDL (good) or both? And did your doctor do a coronary scan (checking for plaque build up)?

What you don't want is LDL Cholesterol building up as plaque in the arteries, there is some connection to plaque build up and LDL levels.

High HDL cholesterol is associated with low risk of heart disease.

Typically a LCHF diet raises HDL (i.e. lower risk of plaque build up and heart disease). In some people LCHF diets raise both LDL and HDL, but the ratios are typically and overall improvement (meaning less plaque build up). The goal with health isn't low cholesterol necessarily, its low plaque buildup.

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#89
post #81
post #4

I was on a low-carb diet for a while. Loved it. Felt great. Was totally fit. All my digestive problems cleared up. I would never get "hangry". By every single subjective measure my quality of life and sense of well-being improved. Then I got my cholesterol checked during a routine blood work and it was through the roof. WTF? Anyone know better than me about this?

There is an incredible amount of confusion surrounding cholesterol, mostly because of the incredible amount of bad/old/incomplete science around which many major medical associations base their recommendations. To put it simply, using "cholesterol" as an indicator for anything is a completely oversimplified view originating in the 50s, when we didn't know enough molecular biology to know better. We've since moved on…

totally. looking at LDL-P is a better indicator that looking at “cholesterol”. There are cases where LDL-C looks okay but you have a large number of particles or cases with elevated LDL-C but with normal number of particles.

Re: Low carb diet leads to “clinical remission” in 3 cases of type 1 diabetes

#90
post #75

Earlier quoted context omitted.

It's expensive but not as bad as you'd think. I didn't have insurance for half a year, and I just called the manufacturer and got a huge discount ($200/bottle -> $35/bottle). One bottle lasts a month or so. This was only due to not having insurance and wasn't need-based - I had earned FAANG income earlier that year and the year before.

Both those prices seem excessive.

The best part of economic freedom is that one is free to start a manufacturer delivering a cheaper whatever one is complaining is too expensive!
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