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Alarming surge in drug-resistant HIV uncovered

nature.com

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Re: Alarming surge in drug-resistant HIV uncovered

#81

Post by ghostwriter »

iamnotacrook wrote: post #71
malandrew wrote: post #39

Earlier quoted context omitted.

In the US, we’re paying obscene prices because no other country pays their fair share to recoup the cost of development plus bringing the drug to market plus a reasonable margin for the effort. The US should establish an agreement whereby US patients pay a LOT less but that the foreign patients need to pay the same. The amount the industry earns should be low enough to make it reasonably financially accessible to pat…

It's hard to imagine nowadays for many people, but ignorant, uninformed opinions like the one you just typed were quite rare before the internet; now they're commonplace. You're not supposed to make up stuff to defend your country, nor to parrot some crap someone else said without thinking about it. You're supposed to think about stuff and make at least a little effort to determine whether something is true, or wheth…

Can you substantiate your rant with facts? The U.S. for decades has been the leading country in drugs r&d and other countries do use the results of it on subsidized terms.

https://www.abpi.org.uk/facts-and-figures/science-and-innova...

Re: Alarming surge in drug-resistant HIV uncovered

#82

Post by stevesimmons »

malandrew wrote: post #39
dillondoyle wrote: post #35

Earlier quoted context omitted.

I can confirm in the US it is truly that expensive (which is fucking crazy). I have pretty good insurance (or at least the best I can get self-buying) but I still have to pay 30% of meds costs. That is something like $400 /month. Luckily Gilled will reimburse up to 7500 /year. Fucked up private insurance in US, they charge that much and then do the reimbursement so they can bill the huge monthly cost to plans / gover…

In the US, we’re paying obscene prices because no other country pays their fair share to recoup the cost of development plus bringing the drug to market plus a reasonable margin for the effort. The US should establish an agreement whereby US patients pay a LOT less but that the foreign patients need to pay the same. The amount the industry earns should be low enough to make it reasonably financially accessible to pat…

I once presented to the monthly board meeting of one of the biggest global pharma companies. The audience was the top execs plus the top-10 country heads.

All they talked about during the dinner was price fixing, tricky deals to block generics, and schemes to maximise the amount they could get each country to pay. Nothing about the science, medicine behind the drugs, or benefits to patients.

That's the reality of pharma today.

Re: Alarming surge in drug-resistant HIV uncovered

#83

Post by ekianjo »

stevesimmons wrote: post #82
malandrew wrote: post #39

Earlier quoted context omitted.

In the US, we’re paying obscene prices because no other country pays their fair share to recoup the cost of development plus bringing the drug to market plus a reasonable margin for the effort. The US should establish an agreement whereby US patients pay a LOT less but that the foreign patients need to pay the same. The amount the industry earns should be low enough to make it reasonably financially accessible to pat…

I once presented to the monthly board meeting of one of the biggest global pharma companies. The audience was the top execs plus the top-10 country heads. All they talked about during the dinner was price fixing, tricky deals to block generics, and schemes to maximise the amount they could get each country to pay. Nothing about the science, medicine behind the drugs, or benefits to patients. That's the reality of pha…

Not just pharma. Most industries care about increasing profits and blocking competitors. Hardly surprising since Top execs are measured on such metrics.

Re: Alarming surge in drug-resistant HIV uncovered

#84

Post by nootropicat »

DanBC wrote: post #62
jxramos wrote: post #10

I always felt like the only way you can eliminate the spread of a highly adaptive std is to develop a low barrier on-the-spot test administered just before intercourse at the latest or some point reasonably earlier in a date or whatever. This would still fail under the dormancy period viruses assume but it should improve the odds I'd imagine for those connected in one way or another to promiscuous sexual networks.

A test exists. It's good but not perfect. If you have the disease it will return positive 99% of the time. If you do not have the disease it will return positive about 1% of the time. About 0.1% of the population has the disease. You take the test. It returns positive. What are the chances you have the disease? People on HN may be able to work this out, but I guarantee that many people (including doctors and nurses)…

That 0.1% includes newborns, the distribution of hiv is definitely not uniform. What are the chances if the person in question is a gay man that uses the test before unprotected receptive anal sex with newly met strangers?

Re: Alarming surge in drug-resistant HIV uncovered

#85

Post by ekianjo »

iamnotacrook wrote: post #71
malandrew wrote: post #39

Earlier quoted context omitted.

In the US, we’re paying obscene prices because no other country pays their fair share to recoup the cost of development plus bringing the drug to market plus a reasonable margin for the effort. The US should establish an agreement whereby US patients pay a LOT less but that the foreign patients need to pay the same. The amount the industry earns should be low enough to make it reasonably financially accessible to pat…

It's hard to imagine nowadays for many people, but ignorant, uninformed opinions like the one you just typed were quite rare before the internet; now they're commonplace. You're not supposed to make up stuff to defend your country, nor to parrot some crap someone else said without thinking about it. You're supposed to think about stuff and make at least a little effort to determine whether something is true, or wheth…

Do you have any argument at all against what they mentioned?

Re: Alarming surge in drug-resistant HIV uncovered

#86

Post by DanBC »

nootropicat wrote: post #84
DanBC wrote: post #62

Earlier quoted context omitted.

A test exists. It's good but not perfect. If you have the disease it will return positive 99% of the time. If you do not have the disease it will return positive about 1% of the time. About 0.1% of the population has the disease. You take the test. It returns positive. What are the chances you have the disease? People on HN may be able to work this out, but I guarantee that many people (including doctors and nurses)…

That 0.1% includes newborns, the distribution of hiv is definitely not uniform. What are the chances if the person in question is a gay man that uses the test before unprotected receptive anal sex with newly met strangers?

But that scenario makes the test pointless: there are a wide range of things to be prevented and safer sex is a better solution than testing.

Re: Alarming surge in drug-resistant HIV uncovered

#87

Post by mantap »

roel_v wrote: post #79
dtornabene wrote: post #74

Earlier quoted context omitted.

What purpose does the phrase "geographically distant" serve here? Seriously, why include that? Because, for one thing, while this site was started by an american, in america, its absolutely read all over the world, and two, HIV rates are highest in these "geographically distant third world countries". This is a really strange thing to post.

It meant (to me) that there are several 'pockets' of this happening simultaneously, it's not some local 'strain' or 'outbreak'. I thought it was a crucial thing to add, for nuance. Not sure why you're so agitated over this.

With the advent of air travel most of these geographically distant places are less than 24 hours away.

Re: Alarming surge in drug-resistant HIV uncovered

#88

Post by nness »

jimbob45 wrote: post #2

Well, PrEP is a miracle drug that has gone criminally underutilized in the fight to eradicate HIV. It would be nice to see governments really push it hard for a change.

In many countries it's easy and relatively cheap the get. It's horrible it's only available with insurance and high costs in the US.

For those curious; in Australia, it's prescribed and costs about $50-60 p/month. In the UK, it varies; England and Wales are doing trails, and Scotland it's prescribed. Under the NHS, it's £9. In Canada, the generics cost upward of $300 per month.

(https://www.prepwatch.org/)

Re: Alarming surge in drug-resistant HIV uncovered

#89

Post by swebs »

jlangenauer wrote: post #20
Aloha wrote: post #14

Earlier quoted context omitted.

PrEP is hard to get, my doctor outright refused to prescribe it to me, they said they were not comfortable doing so

The get a new doctor, one who values your health more than their antiquated morals.

That's a big assumption that the doctor's decision was based on personal morality rather than the damage caused by side effects, etc

Re: Alarming surge in drug-resistant HIV uncovered

#90

Post by nness »

lm28469 wrote: post #77
jimbob45 wrote: post #2

Well, PrEP is a miracle drug that has gone criminally underutilized in the fight to eradicate HIV. It would be nice to see governments really push it hard for a change.

Miracle drug with unknown long term side effects* I wouldn't take it unless I was a non monogamous gay man[0], the risks out-weights the benefits in any other demographics imho. [0] not that I have anything against that per say, it's just statistically the most affected demographic

I don't follow your comment; The drug is intended for those people at risk of contracting the disease. Why would you take PrEP if you weren't at risk?

(Your also discounting drug users; but unfortunately those addicted and at risk are also the least likely to have the means to acquire the drug.)

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