Live data from Hacker News

Single-dose propranolol tied to ‘selective erasure’ of anxiety disorders

mdedge.com

81–90 of 122 posts

Re: Single-dose propranolol tied to ‘selective erasure’ of anxiety disorders

#81

This does not surprise me one bit. I was prescribed beta blockers for "heart problems" that turned out to be panic attacks and I noticed the same effects. On beta blockers you're able to talk about unpleasant memories as casually as one would note the weather. It's a surreal experience, but a useful one. Before this it was easy to shut down and avoid confronting bad memories. Now I can just brush away everything. Ano…

If caffeine is making you jittery then why drink it?

Re: Single-dose propranolol tied to ‘selective erasure’ of anxiety disorders

#82
post #35

I have been taking low dosage Propranolol for about a year now. It was prescribed for me for my hemiplegic migraines. Combined with exercise and occasional CBD oil it has completely eliminated migraines from my life. This medication is absolutely brilliant and harmless. Also keeps my resting heart rate around 55. If you struggle with migraines, talk to your neurologist, for me it was a life changer.

The same thing happened to me, and it unexpectedly was a huge relief for my anxiety. I went off of the propanolol about two years ago after losing a considerable amount of weight, thinking that I no longer needed it. My work performance suffered and I was having considerable difficulty finding a job and was getting the same sorts of crippling anxiety I'd had in my 20s.

It took about a year and a half to finally have a light bulb moment that the Propanolol was the major difference between the most successful and prosperous years of my life and the parts of my life where I've been an anxious hot mess. I'm so glad I stumbled upon this medicine as it's truly made my life more meaningful in allowing me to achieve what I'm really capable of as a software developer.

Re: Single-dose propranolol tied to ‘selective erasure’ of anxiety disorders

#83
post #73

Earlier quoted context omitted.

The 15 that got placebo didn’t get propranolol

But it's not clear if they were exposed to the tarantula.

from the punctuation and sentence structure, it is saying that "15 got placebo" meaning in the same situation as the previous statement (with tarantula). Also, what purpose would there be to having people take a placebo and be in a normal situation?

Coincidentally, I recently listened to an interesting Revisionist History episode that covered the importance and controversy of a semicolon in the interpretation of a section of the constitution

http://revisionisthistory.com/episodes/21-divide-and-conquer

Re: Single-dose propranolol tied to ‘selective erasure’ of anxiety disorders

#84

This does not surprise me one bit. I was prescribed beta blockers for "heart problems" that turned out to be panic attacks and I noticed the same effects. On beta blockers you're able to talk about unpleasant memories as casually as one would note the weather. It's a surreal experience, but a useful one. Before this it was easy to shut down and avoid confronting bad memories. Now I can just brush away everything. Ano…

If caffeine makes you jittery, try out those time-release caffeine pills and a tall glass of water. I've replaced morning coffee this way, and it's great.

Re: Single-dose propranolol tied to ‘selective erasure’ of anxiety disorders

#85
Propranolol massively improved my quality of life. I used to get panicked at the prospect of public speaking, but with propranolol I feel like I could give a nationally televised State of the Union address with no problem.

I take it only before public speaking, not regularly. The only downside is it leaves me with dry eyes and exhaustion at the end of the day, but it’s a small price to pay for the huge QoL improvement.

Re: Single-dose propranolol tied to ‘selective erasure’ of anxiety disorders

#86
A lot of people are saying it's "erasing" the memory. I actually think the way it works is much simpler. I've read that when you relive any memory your brain essentially unloads it, then rewrites it (sometimes in a modified form).

So like think loading a block of memory then rewriting it, but this time you rewrite the memory without the associated anxiety.

Re: Single-dose propranolol tied to ‘selective erasure’ of anxiety disorders

#87

As someone who has used propranolol on and off over the past few years, the thing that intrigues me here is that propranolol works well in this instance due to crossing the blood/brain barrier as opposed to other beta blockers that do not. The use of beta blockers in anxiety is commonly associated with reducing the effects of stress on heart rate and blood pressure, not necessarily on affecting the brain directly whi…

> That is, beta blockers are usually a band aid rather than a fix,

Anxiety is complex and is not just the mental experience, which is why therapy for anxiety uses "hot cross bun diagrams" to describe the feedback loops that physical sensation contribute to.

See the "physical" boxes: https://www.researchgate.net/figure/Five-aspects-of-the-hot-...

http://cbtmidsussex.co.uk/aboutcbt.html

So they're not really a band aid, they're helping with one part of that feedback loop.

Re: Single-dose propranolol tied to ‘selective erasure’ of anxiety disorders

#88

Living with someone with crippling PTSD and anxiety disorders, I'm thrilled to hear about this study. As someone who's dealt with an oppressive government (which is where the PTSD and anxiety came from), I wonder if this therapy can be weaponized by the powerful to oppress the powerless. The rise of the warrior cop is bad enough, but what about a crack squad that has been chemically desensitized to killing in cold bl…

I expect weaponization of drugs from malicious governments will come in a far more effective fashion. There's no need for oppressive cops if you can simply drug your population. Not only wipe away their anxiety, but any concept of fight or flight (the root of anxiety disorders) whatsoever. Pair it with increasingly endless entertainment, plummeting testosterone levels, and a general effeminization of society and you'd never need concern yourself with losing your grasp on power.

In Brave New World, this was soma. "A gram is better than a damn."

Re: Single-dose propranolol tied to ‘selective erasure’ of anxiety disorders

#89

A lot of people are saying it's "erasing" the memory. I actually think the way it works is much simpler. I've read that when you relive any memory your brain essentially unloads it, then rewrites it (sometimes in a modified form). So like think loading a block of memory then rewriting it, but this time you rewrite the memory without the associated anxiety.

As a person with depression and anxiety, I've definitely noticed my memories change based on my mood whenever I recall them. I'd remember professors having harsh tones and cold body language, but then see them acting completely different in a class a year or two later. They hadn't changed; it was that, during my depressive episodes, I'd always obsess over classes I skipped or failed.

I took it as a product of not having a photographic memory. When my mind recalled the memory, there were a lot of parts missing: hand gestures, voice volume, other students, etc. So my brain filled in those gaps with "reasonable" guesses. And, during a depressive episode, it was reasonable to assume other people didn't like me. These additions became part of the memory.

Even with the depression and anxiety under control, I keep in mind that memories can be emotionally altered. So I'm more willing to believe my memories are wrong. And I don't let myself obsess over a memory, which was never productive, anyway.

Re: Single-dose propranolol tied to ‘selective erasure’ of anxiety disorders

#90
Use in anxiety disorders is not really a new phenomenon. It's a non-selective beta blocker that's been used in performance anxiety for decades. I have to give a talk in 6 months and I'm going to prescribe myself propranolol so I can give the talk without feeling adrenergic sympathetic activation/fight or flight. So if I can't feel a sympathetic response centrally or peripherally, I'm going to have minimal performance anxiety and therefore no fearful memories of the event. Hopefully it goes smoothly. I would hate to be calm and give a pathetic shitshow of a talk and then not feel bad about it later..
Post reply on HN