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23andMe Informed Me My Husband and I Are Related

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Re: 23andMe Informed Me My Husband and I Are Related

#81

The sociological effects of DNA matching sites are going to be interesting to watch. I personally found out a year or so ago that my dad wasn't my biological father. At the age of 45, that's an, um, interesting secret to suddenly discover. Now, imagine what happens in a society with strict laws/rules/mores about this sort of thing? Well, we won't have to imagine for long. I'm quite sure my experience is a lot more co…

Did you have to specifically sequence your and your father's DNA at 23andme for that?

Re: 23andMe Informed Me My Husband and I Are Related

#82

Earlier quoted context omitted.

Allow me to offer a different perspective: I've used 23andme and it was one of the best decisions ever. Not so much for the Ancestry part, which was also interesting and explained my above-average cold tolerance, but for the health stuff. Granted, being from Europe they don't directly offer health services, but you can get the raw data and upload it to various sites for interpretation -- ranging from really accessibl…

> explained my above average cold tolerance ... I knew what to look for... Sorry but this makes it sound like horoscope reading. If you can't rely on it to make predictions and only use it to confirm preexisting ideas about yourself how is it better than pseudoscience?

I don't follow / maybe what I meant got lost in language.

To rephrase:

- there were some things in the report that I already knew, it was nice to see confirmation -> points++

- there were some things in the report that I suspected, but wasn't sure about, also nice to see it written black-on-white -> points++

- there were some things in the report which I had no clue about, but were easy to test if they are true or not (they were) -> points++++++++++++++

And to keep it fair: there were also things which didn't really apply at all.

But my point was, because I knew what to observe better, it was easy to keep the relevant stuff and ignore the rest.

Re: 23andMe Informed Me My Husband and I Are Related

#83

I work in genomics. My lab, many of my friends and acquaintances work in genomics or had to dabble with it for at least one of their projects. You would think we would all be fascinated by this stuff, getting to know your own DNA and everything. Yet I don't know a single person who would even consider using 23andMe's service. To me this is all an elaborate scam. Why on earth would you pay them to give them your data…

This is a silly argument. Do you expect to get a free X-Ray because they're just showing you your own bones?

Re: 23andMe Informed Me My Husband and I Are Related

#84
post #53

You share (about) 1/128 of your genes with a third cousin. The chance of any (particular) recessive trait being passed on from both parents as a result of the inbreeding is a whopping 1 in 65,536.

I'm not an expert on this, so perhaps you could tell me if a family history of cousin marriage increases the likelihood of the recessive trait being passed by both parents. I mean, if for the last 10 generations a family has been marrying cousins to each other and introducing little variation from people outside the family, the odds are increased, right? I'd imagine cultures with a history of cousin marriage, such as…

Yes. See, for instance,

https://www.researchgate.net/publication/8326382_Influence_o...

and for some wider background and reassurance see:

https://www.researchgate.net/publication/38114212_Commentary...

Re: 23andMe Informed Me My Husband and I Are Related

#85
Here is the transcript of a recent, interesting audio podcast with Anne Wojcicki, CEO of 23andMe. https://www.recode.net/2018/10/20/18002614/anne-wojcicki-23a... I think what she argues in the podcast is quite reasonable.

Asked about the biggest mistake her startup made in the founding phase, she answered that " I think that we were overly optimistic about the state of scientific literacy in this country. "

And that is true in general. I live in Germany, I am a 23andMe customer, and from my results I learned quite a bit about myself. Locally, whenever I tried to talk about this genetic testing service, I have never had a deeper conversation about this subject matter, even with highly educated folks. It's similar to non-conversations about email encryption and IT security many of you readers might have had.

Re: 23andMe Informed Me My Husband and I Are Related

#86
post #81

The sociological effects of DNA matching sites are going to be interesting to watch. I personally found out a year or so ago that my dad wasn't my biological father. At the age of 45, that's an, um, interesting secret to suddenly discover. Now, imagine what happens in a society with strict laws/rules/mores about this sort of thing? Well, we won't have to imagine for long. I'm quite sure my experience is a lot more co…

Did you have to specifically sequence your and your father's DNA at 23andme for that?

No, my older brother joined and it turned out we we're half brothers, which lead to the truth.

Re: 23andMe Informed Me My Husband and I Are Related

#87

The sociological effects of DNA matching sites are going to be interesting to watch. I personally found out a year or so ago that my dad wasn't my biological father. At the age of 45, that's an, um, interesting secret to suddenly discover. Now, imagine what happens in a society with strict laws/rules/mores about this sort of thing? Well, we won't have to imagine for long. I'm quite sure my experience is a lot more co…

And 23andMe may know who you real father is from the lineage network they can build out of their database.

Yep, already found him. He passed away 20 years ago, but I discovered I have a couple half-siblings still alive, and lots of half-nieces and nephews.

Re: 23andMe Informed Me My Husband and I Are Related

#88
post #19

Third cousins sounds like a non-issue to me, and it sounds like the author and spouse generally agree. I've never knowingly met any second cousins or any other descendants of my great-grandparents (who are not also in my grandparents' lineage). I wonder if there are any estimates on how common unaware third-cousin marriages are.

It’s interesting how much that can vary. I’ve met every one of my second cousins on 3 out of 4 family branches (one grandparent was estranged from their family). Those who live nearby I’m closer with than first cousins who live further away. My and my siblings’ children will also know some of their third cousins, and see them at least once every few years at holidays. I’ve met a couple third cousins, and am fairly ce…

It is fascinating how people grow up with such varying connections with their extended family. Even growing up I would only see my grandparents, aunts and uncles, and first cousins once or twice a year at major holidays.

Most years there would be a nearby annual family reunion of my mother’s mother’s parents’ lineage. I remember it mostly as a lot of older people I didn’t know, and none of them lived near me (the venue was a 2-3 hour drive from where I grew up, and I don’t know how far other people drove.)

But in my high school class there were definitely lots of people who seemed to be cousins with each other, and had massive family reunions in town. In high school my friends always joked about these extended family events as a hassle, but part of me thinks that perhaps I missed out on something there.

It’s interesting to think about the factors that influence a child’s experience with extended family. I grew up only two hours from where my mother grew up, while my father had moved quite far before meeting my mother. My mother had two siblings and my father had one, which is perhaps on the low side for America in that time (my parents were born in the 1950s).

Another interesting thing is that I have never met anyone outside my immediate family with my last name. My father only had one sister, who was married, so those cousins have a different last name. My father’s father died young (long before my parents met), and my grandmother remarried, so she had a different surname for my entire life.

I grew up in a very small town in a rural area, and I would have expected this to be the sort of place to be where people don’t move far from home and where extended families stay close together. But even my extended family in the same US state (but a couple hours’ drive away) was never super close to me. I barely escaped high school before social media went mainstream, so I wonder if I would have forged closer relationships with my extended family with the help of social media.

Re: 23andMe Informed Me My Husband and I Are Related

#89

Earlier quoted context omitted.

Allow me to offer a different perspective: I've used 23andme and it was one of the best decisions ever. Not so much for the Ancestry part, which was also interesting and explained my above-average cold tolerance, but for the health stuff. Granted, being from Europe they don't directly offer health services, but you can get the raw data and upload it to various sites for interpretation -- ranging from really accessibl…

> explained my above average cold tolerance ... I knew what to look for... Sorry but this makes it sound like horoscope reading. If you can't rely on it to make predictions and only use it to confirm preexisting ideas about yourself how is it better than pseudoscience?

I have always been "sickly." Getting my genetic disorder properly identified was amazingly empowering and life changing in the most positive way.

Re: 23andMe Informed Me My Husband and I Are Related

#90
post #35

The author using the word "mansplaining" disqualifies her from any hint of professionalism

The word wasn't used in the pejorative sense in the article.

Considering how this and my comments have been flagged we hit right on the mark. You can't casually use sexist remarks towards women, but apparently not only is it OK to use them towards men, but mentioning it as negative results into flagged post.
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