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Nootropics

gwern.net

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Re: Nootropics

#81
post #54

Earlier quoted context omitted.

You're not alone but unfortunately there's a lot of people on this site who are extremely irrational but think they are very rational.

People on both sides of this would probably say that about each other. (And on both sides of many other issues I might add.)

Yeah people say that on both sides of evolution, global warming, vaccines and lots of other subjects where one side is factually off their rocker.

Re: Nootropics

#82
post #49

Earlier quoted context omitted.

If you take a consistent low dose of Adderall at least, there should be nothing wrong with taking it every day and might actually be preferable that way, otherwise you're in for a rollercoaster effect. The longer you're on though, up to a point at least I imagine, assuming the dose is consistent, you will have a greater withdrawal period that will really suck compared to if you only use them recreationally, which I c…

Different drugs affect people differently. I was rendered incapable of driving safely with a moderate dose of Addreall (30mg), and still felt somewhat unsafe with a low dose of Adderall(15mg). The main effect was that I could no longer subconsciously distinguish moving objects from non-moving objects (I had to think "is that car parked or moving" rather than being able to just tell by looking). My weight is 105kg.

That's pretty interesting, though like the other replies, I don't think I would call 30mg (in a single dose) moderate, but that's neither here nor there with your situation.

Like you said, drugs like this affect people differently and it all depends on the neurochemistry of the individual, which to the best of my knowledge they don't (can't?) test for when they prescribe this stuff.

I was taking 30mg / day (15mg twice a day) and was pretty functional, though I think the dose might have been too high. Later on I would drop down to 15mg / day (7.5mg twice / day) and that was the sweet spot.

Re: Nootropics

#83
post #56
post #49

Earlier quoted context omitted.

Different drugs affect people differently. I was rendered incapable of driving safely with a moderate dose of Addreall (30mg), and still felt somewhat unsafe with a low dose of Adderall(15mg). The main effect was that I could no longer subconsciously distinguish moving objects from non-moving objects (I had to think "is that car parked or moving" rather than being able to just tell by looking). My weight is 105kg.

Is 30mg really a moderate does? When I had a pers ription for Aderral, 20mg was enough to make me feel like I was going to die.

30mg in a single dose is fairly high. It's not so bad if you split that into two doses over the course of a day, but still kind of high for the average person.

Re: Nootropics

#84
post #54

Does anyone else think this shit is totally bat shit crazy? I may be of the minority here but I am definitely not the minority in the real world. If you care about health why not exercise and eat healthy and never take any type of drug for any reason unless you are sick.

You're not alone but unfortunately there's a lot of people on this site who are extremely irrational but think they are very rational.

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Re: Nootropics

#85
post #31

No mention of methylene blue? :O It's the best one! Below is a post I wrote on a Ray Peat Facebook group that I think fellow coders and behind-a-desk workers might fight interesting. I've been a serious procrastinator and slacker, and it was a long journey of trial and error in getting diet and lifestyle right. I'm thankful to the amazing work of Dr. Ray Peat, which isn't mentioned enough around Hacker News. ⁂ Some c…

[deleted]

Re: Nootropics

#86
post #53

Earlier quoted context omitted.

He probably has tried drug free, exercise and sleep over a month.

Where's the write up? Many people, including myself, find exercise to be mind numbingly boring, and intellectually insulting. (Pick up a weight and put it down? That is quantitatively zero work, buddy. No thanks.) Never underestimate the motivation to find a quick fix.

> Many people, including myself, find exercise to be mind numbingly boring, and intellectually insulting.

I used to think the same way but decided one day that I was going to walk/jog ~10km every day and eat healthy. Now, I really enjoy walking. It gives me a chance to think about the problems I've been trying to solve during the day, what I'm going to do tomorrow, etc. And at some point I actually started enjoying the _feeling_ of doing exercise. It's hard to describe, and I know that myself from 12 months ago would believe me but I definitely wouldn't want to stop exercising.

So my recommendation is to spend your time while exercising thinking about whatever was bothering you during the day. It's quite relaxing, frankly. To be fair, my exercise routine doesn't include the gym but the same logic applies there.

> (Pick up a weight and put it down? That is quantitatively zero work, buddy. No thanks.)

While true if you're using the strict physics definition of work, its not true if you use the common meaning of the word.

Re: Nootropics

#87

The best nootropic is getting a good nights sleep. It takes effort! Preparing for bed early and disciplining yourself to put the light out is not easy. Not nearly as easy as popping a pill. But it's so much more effective than any drug listed here. And for a safe and provable quick cognitive boost, take some caffeine, preferable green tea with theanine.

It can't be "so much more effective", otherwise the Air Force wouldn't give stims to pilots.

And anyways, why not both?

Re: Nootropics

#88

Does anyone else think this shit is totally bat shit crazy? I may be of the minority here but I am definitely not the minority in the real world. If you care about health why not exercise and eat healthy and never take any type of drug for any reason unless you are sick.

I don't see why you couldn't eat healthy, exercise, and take melatonin (for example). He brought up an excellent point in his essay about melatonin that although being purely "natural" may be beneficial, we don't live in a natural world. We expose ourselves to blueish light far more than our ancestors.. so why wouldn't it make sense to counteract that artificial influence with something like melatonin? There's nothin…

I've found melatonin best used not on a regular basis, but on nights you know it will take extra time to get to sleep, or when you have to wake early. Its more about keeping your sleep schedule in check.

"Conservatively, a bottle of melatonin pills will cost about 6 USD for 150 pills". This is the part I find interesting. I live in NZ, and melatonin isn't readily available - unlike most drugs here it's not government subsidized. It costs $20 for 10 pills, and you have to visit a doctor.

Crazy accessibility and cost difference.

Re: Nootropics

#89

Melatonin has made it possible for me to sleep much more consistently which has been a huge help, since I saw Gwern's post on it a while ago.

Melatonin has worked wonders for me as well. However it's worth mentioning that the 3mg capsules I bought are WAAAY too strong and cause me to wake up with a dry mouth and a headache after a couple of hours of intense dreaming and nightmares. Instead now I split the caps open and take a tiny fraction of the melatonin every night. It takes me a few weeks to go through a single capsule.

Interesting how different doses affect different people differently.

Melatonin works great for me as well. I take 5mg. Not sure if my dreams are any more vivid than without it, as I've been taking it every night for years. I think I've always had vivid dreams, though I no longer get recurring nightmares (which I had years prior to taking melatonin; not sure when they ended).

Re: Nootropics

#90
post #10
post #7

A summary would be awesome - I appreciate the amount of work and details that went into this, but a list of what worked and didn't would be a great start - interested readers could then dive into details

Reddit actually has an active nootropics community with a wiki for beginners: https://www.reddit.com/r/nootropics/wiki/beginners . The standard stuff is L-Theanine + Caffeine. For cognitive enhancement any of the "racetams" are considered proven, and you branch out into untested army drugs when you take modafinil. I've tried each of these and stick with L-Theanine and Caffeine daily. Piracetam had no visible effect o…

Very cool! Thanks for the info!!
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