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OxyContin's 12-hour problem

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Re: OxyContin's 12-hour problem

#81
post #20
post #13

The best part of the article: "Dr. Curtis Wright, who led the agency’s medical review of the drug, declined to comment for this article. Shortly after OxyContin’s approval, he left the FDA and, within two years, was working for Purdue in new product development, according to his sworn testimony in a lawsuit a decade ago." Says it all doesn't it?

What does it say?

Quid pro quo. You scratch my back and I'll scratch yours 2 years later.

Re: OxyContin's 12-hour problem

#82
post #54

Earlier quoted context omitted.

Another way to remember is that "library" and "libel" both come from "liber", meaning "book" in Latin

As does "lb.", the abbreviation for pound.

No, "lb." comes from "libra" meaning scales or balance, not "liber".

https://en.wikipedia.org/wiki/Pound_(mass)#Roman_libra

Re: OxyContin's 12-hour problem

#83
> The U.S. Justice Dept. launched a criminal investigation, and in 2007 the company and three top executives pleaded guilty to fraud for downplaying OxyContin’s risk of addiction. Purdue and the executives were ordered to pay $635 million.

A mere fine for ruining the lives of hundreds of thousands, if not millions of people.

Re: OxyContin's 12-hour problem

#84
post #61

Earlier quoted context omitted.

You are wildly off base to the point that you seem like a shill. Learn about tort law and the first amendment. Besides it not being injurious or necessarily false, It involves a public official so good luck proving actual malice.

Your response seems unnecessarirly harsh. Please be more civil (HN strives for civility) and understand that HN has a global audience with differing laws (the parent could use this same perspective that HN is global).

"I think your opinion is illegal" as a way of shutting someone down deserves quite a harsh response.

Re: OxyContin's 12-hour problem

#85
I had three orthopedic surgeries in 2014. Each time I got a vial of OxyContin. Figured I'd use 'em since I'm not much into pain. But the pain was not so bad. Once I tried an OxyContin to see if I could tell the difference. I could not.

A colleague tells me that they have a street price of like $40/pill. So then I'm wondering how many people know that I have a thousand dollars worth of street drugs in my house. I dropped them off at the local drug disposal facility.

Re: OxyContin's 12-hour problem

#86
post #42

Earlier quoted context omitted.

> Many people are inappropriately given opiates by their doctors to treat long term pain. While I am sure this is true in many cases, my personal experience was the opposite. I had significant nerve pain after an accident, which kept me from being able to sleep or focus on anything very well. The physician I saw after my hospitalization was apparently worried I was trying to satisfy a drug-craving? So instead of givi…

> I had significant nerve pain after an accident, which kept me from being able to sleep or focus on anything very well. Was that in the weeks or months after the accident? Or was it some time after that? Pain after accidents is short term (acute) pain, and I'm only talking about long term (chronic) pain. EDIT: Either way, it sucks that you didn't get good enough treatment, and I'm sorry you went through that. Pain f…

> Was that in the weeks or months after the accident? Or was it some time after that?

> Pain after accidents is short term (acute) pain, and I'm only talking about long term (chronic) pain.

It was a month after I was discharged (so two months after the accident). Probably given the sentiment here and on other media I could have shopped around for a different physician - but when you are recovering from an accident that really isn't an initial concern and one is inclined to trust medical decisions of professionals - my overall takeaway is that this anti-prescription drug-abuse wave that ran through the media/public and it's impact on healthcare had a distinctly negative effect at least on my personal treatment.

Sure, it's anecdotal but I really would be curious to know what percentage of doctors are contributing to prescription drug abuse vs. the weight of the contribution; somehow I think it's more likely that a very small percentage account for the bulk of the abused prescriptions.

Re: OxyContin's 12-hour problem

#88
post #87

It will be interesting to see how well CBD (Cannabidiol) based medications work once the doors open to prescribed usage on a national scale.

I'm pretty sure that big Pharma is scared to death that it's efficacy will prove to be very high.

Re: OxyContin's 12-hour problem

#89
The problems derive from the prohibition, which takes several forms. The forms add up for big profits and bad incentives, for which the consumer pays.

FDA approval is the first layer of prohibition. Very expensive, this keeps a lot of competitors out. Lots of market (read: pricing) power is conferred to the winners. Great incentive is provided for regulatory capture.

The second layer is patent protection. Again, competition becomes illegal, with outcomes similar to above.

Third is scheduling it as a prescription drug. The incentives of the drug company are now to influence doctors, in ways that may be more or less overt. Docs get a cut of the outsize profits, de facto.

The fourth layer is opiates being illegal in general. Competitors out.

Of course there are legitimate reasons for prohibition, even if I don’t agree with them. One can make an argument for protecting people from harming themselves.

But these arguments are naive and static. By “dynamically scoring” the cost of prohibition – following the incentives and the outcomes – we might choose differently.

Re: OxyContin's 12-hour problem

#90

Really the duration can vary quite a lot. I was put under on fentanyl for having my wisdom teeth taken out and woke up in the middle of the operation in extreme pain as someone was digging my teeth out with a metal instrument. I moaned at him, through a mouth stuffed with gauze pads, to get the fuck off me and let me out of there if he wasn't giving me more meds. He proceeded to angrily accuse me of taking dope, whic…

I woke up when I was having my wisdom teeth extracted but promptly went back to sleep when they suggested it. My recollection is that I was briefly aware of them working in my mouth but not in any pain.

It's remarkable that in the US the much more dangerous general anesthesia is used for routine things like wisdom teeth when anesthetic shots (lidocaine) are significantly safer and simpler. This leads to additional complications due to anesthesia itself, or worse. [1] [2]

If your dentist proposes things like this, please, switch to someone else.

(For those unfamiliar, after the shots you feel not much other than some tugging. And you can get up and walk immediately after.)

[1] http://www.medicaldaily.com/baby-girl-cavity-filling-dental-...

[2] http://wgntv.com/2016/02/23/dentists-license-suspended-after...

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