Ozempic shows anti-aging effects in trial • Hacker News Board

Re: Ozempic shows anti-aging effects in trial

#791

Post by throwawaylaptop » Thu, Aug 07, 2025, 2:12 AM UTC

meroes wrote: post #254

throwawaylaptop wrote: post #194

Earlier quoted context omitted.

? Insulin is not about management of hunger. I think you got your hormones mixed up. But yes, meat and vegetables is basically what I'd recommend. Never pasta or bread or sugar unless you need help gaining weight.

Meat and vegetables would make me sedentary from having inadequate glycogen for physical work and exercise. How about: some pasta and bread to enable physical exertion.

I know a guy that has had meat only for 3 years now. Most fit guy I know.

My father and I have avoided carbs for a few years now. Can do home renovations, gardening, dirt bike riding, and hikes better than we ever did eating carbs. Unless you're doing long distance hikes/running/hard core sports, I really don't think that's true.

Re: Ozempic shows anti-aging effects in trial

#792

Post by declan_roberts » Thu, Aug 07, 2025, 2:42 AM UTC

tracker1 wrote: post #775

In my experience it also showed gastroparesis and fecal vomiting over the course of a couple years. Coming off meant the feeling of starvation 24/7 for about 11 months before starting to get better, and 1.5 years off the medication now, I'm still having digestive issues. Went back to keto (mostly carnivore) in May and a few pounds away from 50# down from my max weight, managed to cut way back on insulin (some days no…

You have fecal vomiting and stayed on the drug for years?

Re: Ozempic shows anti-aging effects in trial

#793

Post by cthalupa » Thu, Aug 07, 2025, 3:08 AM UTC

lurking_swe wrote: post #779

ehnto wrote: post #421

Earlier quoted context omitted.

I think it's controversial mostly because it is mixed in with morality, self-image, personal freedom etc. I think everyone has the right to be fat, if they have chosen to prioritise other aspects of life, but I think people should be informed and consider the "being fat can be healthy" movement to be quite disingenuous. Do what you want, but be realistic about it, and tricking people into ignoring the negative effect…

is there a “being fat can be healthy” movement? I must be unaware. I am aware of the “fat people deserve respect, dignity, and can be beautiful too” movement…which i agree with. But if anyone is saying being fat is healthy, they’re pretending.

Yes, there are a variety of organizations that are attempting to propagate the idea that you can be healthy at any size.

Which, as a formerly obese person, I knew was a load of bullshit even at my fattest. I don't know if anyone actually believes it, or if they just are lying to themselves, but the movement definitely exists.

Re: Ozempic shows anti-aging effects in trial

#794

Post by JumpCrisscross » Thu, Aug 07, 2025, 3:19 AM UTC

fc417fc802 wrote: post #786

JumpCrisscross wrote: post #778

Earlier quoted context omitted.

> your examples have no straightforward solution In humans? No. In our ancestors and every other animal around us? Yes. > we already have the mechanism in question so the question "why doesn't it just ramp up" is quite reasonable Our species almost got wiped out in an ice age less than a hundred thousand years ago [1]. It's possible we had the ability to ramp up GLP-1, but that it got eliminated in a famine. [1] http…

> In our ancestors and every other animal around us? Yes. Right so my point is, with no smooth optimization path towards X in a given species the question "why doesn't species just X" has a readily available answer - because biased random walks are fickle and the pathway likely convoluted. Whereas when a smooth optimization path is available it becomes reasonable to ask "then why isn't species doing X already"? Assum…

> it's an entirely reasonable question that needs to be asked when considering the potential for serious side effects

I agree about it being asked. A lot of times it isn’t being asked, but assumed.

I thought it was snake oil when announced. I’m now beginning to question if it’s closer to a weird vitamin that we face a systemic deficit of.

Re: Ozempic shows anti-aging effects in trial

#795

Post by kalleboo » Thu, Aug 07, 2025, 3:37 AM UTC

sjw987 wrote: post #537

guerrilla wrote: post #527

Earlier quoted context omitted.

Nah man. I'm overweight and despite trying everything I possibly can for most of my adult life, I still can't win. I do everything you're supposed to do but it's just not possible to maintain long-term. It's a constant struggle. You don't have discipline. It's just easier for you. That's all. I still won't use this drug but don't try to tell me I failed because of a lack of effort, understanding, exercise, "disciplin…

You just haven't got there yet. You haven't failed. It really just comes down to eating less and healthier. Some people have metabolic differences either side, but they don't amount to a great deal. Weight loss drugs suppressing your appetite literally shows this to be true. You just need to do it yourself without the drug. Eventually you'd want to come off the drug, right? When that happens, you would need to do jus…

Lots of people have literally died before they "got there". They would still have been alive if they had access to the right medication.

Re: Ozempic shows anti-aging effects in trial

#796

Post by johncolanduoni » Thu, Aug 07, 2025, 4:13 AM UTC

nomel wrote: post #776

johncolanduoni wrote: post #426

Earlier quoted context omitted.

At no point did I say we were immune to unintended consequences. Just that demanding every drug be used for 30+ years before you’ll touch it is not actually making an analysis of the tradeoffs involved. Also, the drug classes you listed are not great examples. Benzodiazepines don’t fit what we’re talking about at all: it’s common to develop tolerance and get serious withdrawal symptoms from a few months of heavy use.…

> Just that demanding every drug be used for 30+ years before you’ll touch it is not actually making an analysis of the tradeoffs involved. Your replies are unnecessarily aggressive, and you’re not reading comments in a charitable way, or keeping track of the usernames writing them. Nobody is saying this.

I also never said we were “immune to unintended consequences”. How charitable was putting those words in my mouth?

Also not sure where your quip about me not keeping track of usernames came from - I responded to specific examples given in each individual comment. They just both happened to bring up benzodiazepines.

Re: Ozempic shows anti-aging effects in trial

#797

Post by loeg » Thu, Aug 07, 2025, 4:52 AM UTC

Nesco wrote: post #437

strken wrote: post #358

Earlier quoted context omitted.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

I am pretty sure uncouplers will make a come back. Just something a little more targeted and safer than good ol’ DNP

But why? Ozempic et al solve the input end of the equation. Burning more and literally being warmer isn't better.

Re: Ozempic shows anti-aging effects in trial

#798

Post by vallassy » Thu, Aug 07, 2025, 4:58 AM UTC

Aurornis wrote: post #228

throwawaylaptop wrote: post #146

Earlier quoted context omitted.

You can be gluttonous and still thin. I eat 2 lbs of ground beef a day, with tons of cheese on it. For breakfast I have 6-8 eggs, with cheese. I have my morning coffee with heavy whipping cream. For desert, I whip up some of the heaving whipping cream and have it with frozen berries thawed out. It drives gfs nuts but they're too anti fat to try it.

Eggs have about 60 calories each. Cooking 2lbs of ground beef could yield a little over 1500 calories (Source https://www.uhhospitals.org/health-information/health-and-we... ) A tablespoon of heavy whipping cream is 50 calories. There's nothing incompatible with what you wrote and a 2500 calorie diet. This confuses a lot of people who associate certain foods with becoming fat, or think that eating fat makes you fat.…

The Journal of the American College of Cardiology has a good paper stating that saturated fat is not linked with CVD or mortality.

https://www.jacc.org/doi/abs/10.1016/j.jacc.2020.05.077

Re: Ozempic shows anti-aging effects in trial

#799

Post by syncmaster913n » Thu, Aug 07, 2025, 5:30 AM UTC

bloomingeek wrote: post #687

JackFr wrote: post #675

Earlier quoted context omitted.

> Ibuprofen ? That's really not something I'd have expected to end up in someone's 'healthy stuff' list. Never knew about the potential stomach bleeds until I took my mother to the hospital earlier this year. Ironically, she was taking Motrin given to her in the same hospital a week earlier.

Sorry to hear. My doc says to always eat something when taking ibuprofen to protect your stomach.

https://www.drugs.com/medical-answers/you-ibuprofen-empty-st...

Re: Ozempic shows anti-aging effects in trial

#800

Post by spauldo » Thu, Aug 07, 2025, 6:02 AM UTC

loeg wrote: post #700

strken wrote: post #358

Earlier quoted context omitted.

"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…

> "No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? We can do science and technology on timescales vastly faster than evolution. "Why didn't evolution do it?" is just a very irrelevant question. >…

Tobacco, and cigarettes in particular, has been used as a medicine for hundreds of years. And it's not just in the distant past - a friend of mine was actually prescribed cigarettes for anxiety about 30 years ago here in the US when he was 14.

There are various health benefits to smoking, believe it or not. They're just outweighed by the downsides.