> I believe that everyone, even the skinny folks, should be on GLP1 drugs for the longevity effects. Are you for real? Serious question.
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‘Breakthrough’ obesity drugs that have stunned researchers
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Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#792[flagged]
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Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#793I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and exercise), and within 8 months I was BMI 23. Losing weight was extremely challenging and socially isolating. 7 years later, I had a bad ankle injury and regained weight to about 29…
Same - Mounjaro / Tirzeparide is nothing short of life changing. A question I often get is "how effective is it?" The SURMOUNT-1 study released in April 2022 showed 22.5% average reduction in weight for people on the highest dose of Mounjaro. For a 250 lbs person who should weigh 150 lbs (so 100 lbs of extra weight), this would result in them losing 56 lbs or 56% of their excess weight. For context, bariatric surgery…
Oh really? Got any more info on that drug?
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#794Earlier quoted context omitted.
> everyone, even the skinny folks, should be on GLP1 drugs Seriously? No thanks. Think I'll give you all a few decades to see what the long-term effects are like, and let my body largely take care of itself except when specific medical issues indicate that an intervention is in order.
it's always really strange to me whenever someone enthusiastically advocates that others use experimental drugs whose long-term side effects have not yet been discovered. if you want to try em yourself then go for it I guess, but I'm good thanks. it's interesting to take a step back and realize just how much pharmaceutical corporations have got average people to think it's perfectly normal to try putting random chemi…
> have got average people to think it's perfectly normal to try putting random chemical compositions into their bodies and see what happens
This smells like you devoured some anti-vaxxer BS, btw. But for the record, these things go through a ton of testing and clinical trials. The reason science types are excited is BECAUSE this class of drug looks safe AND effective... based on the data.
(And I'm also down 35+ lbs on tirzepatide, so far. This is the way.)
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#795Earlier quoted context omitted.
That really is the core of the issue, and furthermore once you've used to a sugar diet you crave it more and regular food starts tasting worse in comparison somehow. I bet it's something to do with the gut-brain connection and a large glut of sugar eating bacteria signalling it's time to feed them. Just a theory, but there is some kind of correlated process there. And the reverse is also true, if you go a while witho…
The first time I tried ketchup after strictly avoiding added sugars for several weeks was a WILD experience. It tasted sweeter than maple syrup. I used to douse my food in ketchup and now I can't even eat it on fries because it's so sickeningly sweet. I noticed the same with most bottled salad dressings and sauces (barbecue sauce and honey mustard being even more egregious than ketchup).
I just came back to North America after 18 months in Australia. Ketchup compared to Tomato Sauce is a wild difference!
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#796Earlier quoted context omitted.
> The thing is, I'm never full. I can eat until I physically can't eat anymore (not something I do regularly, of course), and as soon as my stomach has emptied a bit, I feel fairly hungry again. "Eat until you feel full" is literally a human experience I had never really had. I feel exactly the way you do, and yes, I was fat, lost it in one go and never gained it back. I try to keep my BMI around 18, never went over…
> Not that hard to stop yourself from going to the store again or ordering more Well, actually... I'm fat. Like BMI 40 fat. Most of my life I have been fat. I was laughed at in school for it, as far back as I can remember. It probably wasn't all that bad when I think back. Certainly not as bad as now. But I was the fat kid in class, and I felt like the fat kid. Anyway, I have lost a lot of it at a few points. Once by…
> And eating only candy makes me sick, so I should also buy crisps so I can alternate and keep eating.
This one hit hard. If you swapped "crisps" and "candy" for "MDMA" and "ketamine", people would tell you to go to rehab.
No judgment here, but a lot of your behaviour sounds like addiction underpinned by a coping mechanism. If you replaced with alcohol or drugs people would point out how your relationship with the substance is pathological.
IMO food is the most cruel of addictions as it is fuelled by our most primal of instincts to survive, it is also why I think Big Sugar is the most sinister of institutions...
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#797Earlier quoted context omitted.
I'm also on one of these drugs (Tirzepatide) and have been for a few months. The first time I remember knowing I was fat was when a babysitter made fun of me for it at age 6. I've been fat ever since and I'm in my late 30s now. I've lost significant amounts of weight (60+ pounds) three times in my adult life, through simple calorie restriction (intermittent fasting, including before I'd ever heard the term). Every ti…
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How would you explain skinny smokers then? or skinny drug addicts?
This whole "intellectual willpower" thesis is so stupid it's insulting.
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#798Earlier quoted context omitted.
The body is an energy equation to be balanced. Physics defines that. What you are talking about substantially in your post is about willpower with regards to eating and exercise which is totally different.
> The body is an energy equation to be balanced. Physics defines that. Care to write it?
if ( calories in > calories used) then gain weight (store the excess for later as fat)
if (calories in You can make that on a daily, monthly or yearly timescale, it makes no difference.
Everything we know about physics says it is the only way.
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#799Earlier quoted context omitted.
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And you know what they feel inside their bodies? Something can be true, satisfying, and incomplete. Why do they eat too much? Because of moral failing? Or because a system designed to maintain energy balance in only one direction is incomplete in our modern environment. Hunger is not a moral failing, it is a physiological system.
I didn't mention morality, you did.
Re: ‘Breakthrough’ obesity drugs that have stunned researchers
#800At a risk of being ignorant: Isn’t obesity a function of calories intake and calories burn rate? If so, why do we even need a drug for that? What should a possible drug target here? Assuming no changes in behaviour and thus a continued steady daily caloric surplus, would it even work?
At a really fundamental level, yes, it boils down to calories in versus calories out. However , in practice it's more complicated than that, partially for psychological reasons. Anyone will lose significant weight on a strict enough diet. Unfortunately, severe calorie restriction does things to your metabolism -- basically, your body notices there's not enough food, and tries to slow everything down so that your exis…
> Anyone will lose significant weight on a strict enough diet. Unfortunately, severe calorie restriction does things to your metabolism
Who said anything about "strict" or "severe calorie restriction" ?
To loose weight a person need only regularly eat 100 or 200 calories less than their daily requirement. For many who are obese, we're talking about having one less can of coke per day, or one less slice of a whole pizza or less ice cream every day.
A severely obese person can perfectly well eat McDonald's every single day, and eat more calories than a regular gym junkie and STILL lose weight!