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Ozempic shows anti-aging effects in trial

trial.medpath.com

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Re: Ozempic shows anti-aging effects in trial

#781

Post by y-curious »

cthalupa wrote: post #740
y-curious wrote: post #625

Earlier quoted context omitted.

Right, and it's also not something naturally in the human body. But sugar is also an insecticide when you cook it into a jam. It doesn't really make me comfortable with giant lizard poison

These hormones occur naturally in the body. We found an analog in nature that behaves a bit differently in that it is longer lasting. Now we have synthetic versions based on that understanding. And the gila monsters have their own circulating serum levels of exenedin-4. It's produced in their salivary glands - it's a component in their venom, yes, but they also ingest it themselves, particularly when eating. But thes…

This is a fair point. I am ignorant of how the hormone in our bodies works, and what it's downstream effects are. I'll take a peek at the literature

Re: Ozempic shows anti-aging effects in trial

#782

Post by [deleted] »

cthalupa wrote: post #730
tomxor wrote: post #715

Earlier quoted context omitted.

> The underlying mechanisms (reduced inflammation, improved fat distribution, better metabolic health) aren't unique to that group Those are causes , you can't just invert it (again) and call them mechanisms for anti-aging... Those things are side effects of obesity and diseases causing obesity, there is no evidence or reasonable basis here to suggest there would be any "anti-aging" effect in healthy people without t…

Except the post they responded to specifically called out HIV-associated lipohypertrophy and the post you are responding to pointed out that the issues being tackled are not unique to HIV-associated lipohypertrophy. More than 70% of Americans are overweight. That's a pretty overwhelming majority. Most of the Western world and significant portions of the Eastern world are trending in the same direction. The point is t…

[deleted]

Re: Ozempic shows anti-aging effects in trial

#783

Post by anitil »

nlitened wrote: post #419
radicaldreamer wrote: post #305

Earlier quoted context omitted.

Its the same root cause: they think alcoholism or alcohol dependency is a moral failing so there should be struggle and punishment to overcome it.

Alcoholism is a moral failing, and the struggle and punishment are real, and come not only from outside, but also from within. One can try to rationally argue their way out of alcoholism being a moral failing, but then one notices that in a similar way they can “whitewash” any other moral failing, and the words lose their meaning completely. Yet people use these words to mean something, and abuse of alcohol falls und…

If it is a moral failing, how can a pill resolve it? Does the pill put morals back in the user? While I agree that alcohol abuse is bad (and might make people do bad things, and hurts people around them etc), I'm not sure if the moral argument adds anything to the discussion

Re: Ozempic shows anti-aging effects in trial

#784

Post by ponector »

ykonstant wrote: post #411
toomuchtodo wrote: post #326

Earlier quoted context omitted.

Get a GLP-1 under the supervision of a doctor or other licensed medial provider.

As a chronically obese, non-diabetic individual, here in Greece it is impossible to convince a doctor to prescribe anything close to that :(

Hard to believe. Always can try the same kind of doctors who issue prescription for medical marijuana.

Re: Ozempic shows anti-aging effects in trial

#785

Post by ponector »

jart wrote: post #579
mghfreud wrote: post #499

Earlier quoted context omitted.

Visit Turkey for a couple weeks. Rules are the same, but behavior is the opposite. Weekly dose of 1mg is sold over the counter for around 150$.

And it's thanks to that kind of dishonorable practice that $NVO has lost 64% of its value over the last year. This is how the world rewards the makers of the most successful and helpful drug in history.

I always thought penicillin is the most successful and helpful drug. As well as vaccines against deadly diseases.

Re: Ozempic shows anti-aging effects in trial

#786

Post by fc417fc802 »

JumpCrisscross wrote: post #778
fc417fc802 wrote: post #772

Earlier quoted context omitted.

Both of your examples have no straightforward solution. Whereas we already have the mechanism in question so the question "why doesn't it just ramp up" is quite reasonable. Biology is a highly tuned system.

> your examples have no straightforward solution In humans? No. In our ancestors and every other animal around us? Yes. > we already have the mechanism in question so the question "why doesn't it just ramp up" is quite reasonable Our species almost got wiped out in an ice age less than a hundred thousand years ago [1]. It's possible we had the ability to ramp up GLP-1, but that it got eliminated in a famine. [1] http…

> In our ancestors and every other animal around us? Yes.

Right so my point is, with no smooth optimization path towards X in a given species the question "why doesn't species just X" has a readily available answer - because biased random walks are fickle and the pathway likely convoluted. Whereas when a smooth optimization path is available it becomes reasonable to ask "then why isn't species doing X already"? Assuming a long enough timescale then there must be some selection pressure preventing it.

I agree that the ice age is a reasonable hypothesis. If we were exposed to repeated boom-bust cycles of extended duration (ie multi-generational) then it's at least plausible that we gained some mechanism dedicated to preventing us from adapting in that direction.

Still it's an entirely reasonable question that needs to be asked when considering the potential for serious side effects. If the hypothesis is that this is actively prevented for historical reasons then we should want to see the precise molecular mechanism hunted down in order to validate that. Keep in mind that an alternative hypothesis would take the general form that ramping it up causes serious deleterious side effects in the long term.

It's quite like Chesterton's fence. There must be a reason so we would do well to understand approximately what that might be before tinkering.

Re: Ozempic shows anti-aging effects in trial

#787

Post by astrange »

ggsp wrote: post #681
astrange wrote: post #497

Earlier quoted context omitted.

I meant it cancels out the effect of THC. Which is handy if you've taken an edible and are getting tired of it. But yes, that too.

Oh, now I get it, you're saying that the black pepper "unhighs" you? Never knew that, I'm going to have to try that sometime. Do you just munch on a teaspoon of peppercorns?

Yep.

Re: Ozempic shows anti-aging effects in trial

#788

Post by amy214 »

rybosworld wrote: post #673
radu_floricica wrote: post #390

Earlier quoted context omitted.

Not really applicable in humans. Effect is smaller than in mice, and requires some pretty drastic restrictions that aren't exactly pleasant. The thing with ozempic is that is seems to do several things, most (all?) of them good for us in different ways. We probably just lucked out. It's not the only case - plenty of drugs do incredibly good things with only reasonable side effects. Antibiotics. Ibuprofen. Aspirin. Vi…

Can you say more about Ibuprofen? I've understood it's fairly dangerous in some contexts. Especially for folks with compromised liver function.

tylenol is the one that's hepatotoxic (spanish for harmful to the liver) - ibuprofen is nephrotoxic (italian for harmful to the kidney) maybe you are mixing up your very similar painkillers. in kiddos it's common to go back and forth between them for pain control, thusly attenuating specific insult to liver or kidney. then there's aspirin, don't give that to kids, that's a whole thing
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