Earlier quoted context omitted.
FWIW, my main monitor is a 43" 4k display, and it works perfectly fine on AwesomeWM - but I' don't use any scaling, the 4k is purely for more screen real estate - literally like having 4 perfectly aligned borderless 24" monitors. I can fit 10 full A4 pages of text simultaneously.
I recently upgraded to a 43” 4k monitor and use it the way you describe. I’m not sure I am happy with it. The real estate is nice but it might be too much. UI elements end up very far away. I rarely need all that space. I either need a bigger (deeper) desk to sit back farther or just a smaller monitor physically with the same resolution.
I also was thinking I didn't particularly like the large desktop and screen at first, but now that I treat it as a combined wallboard and desk space, I can't imagine going back (and using the large but not quite 4k monitor at my desk at the office always felt like a step backwards).
I do set default scaling for Firefox and Thunderbird to be about 125% of normal though, as I don't like squinting at small text. I generally like how small all the other OS widgets are though, so I don't scale the whole desktop.