721–730 of 868 posts
This is specifically a study on people with HIV-associated lipohypertrophy, which is associated with accelerated aging. Not clear what this would mean for people generally.
True enough, but many studies show that calorie restriction reduces effects of aging
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> when we use technology to reoptimise our bodies to calorie abundance replace "calorie abundance" with "sedentary lifestyle" and youre there. its people eating more than they burn off because they dont exert themselves because thats what being an adult means.
For part of my life, I was extremely athletic, and after five kids, I did not have time for 6+ hours a day of exercise. Doing one hour per day seemed to do nothing to offset middle age metabolism combined with a high carbohydrate diet. The interesting thing is that once I switched to a keto diet, my body mass changed and my health improved significantly for the better. The interesting thing is that the keto diet is a…
Plenty of ways around it. Some people have a treadmill or spin bike desk setup. Powerlifting doesn’t take much time. You can also eat less.
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This is such an absurd statement. If changing your habits was much easier then we wouldn't need these medications and the world wouldn't keep getting fatter. People have known how to not be fat for a long time, yet the obesity rate has been rising worldwide, even in countries that have traditionally been skinny. It's not like fat people on the whole are ignorant of how to become not-fat and never attempt to do so.
Because people are choosing deliberately to get pleasure to eat unhealthy stuff instead of being healthy. And that’s a reasonable thing to do. Immediate pleasure trumps future hypothetical gains. And it’s exactly the same situation with financial education, debt, university degrees, or in general any long term endeavors that requires the sacrifice of the immediate pleasure. Of course, we still have a non trivial perc…
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"No free lunch" is a reasonable question to ask when evaluating medication, if it would improve the evolutionary fitness of the majority of people. I think this is behind some of the skepticism. If Ozempic is so great then how come our bodies don't just produce more GLP-1? How come we aren't like chimps, with eternally shredded bodies and cheese grater abs, provided we get the protein to support them? I would guess t…
If not having cancer is so great why don't our bodies just not make cancer cells? Weight loss aids are given far more scrutiny because people wrongly view it as a moral failing
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I think many people confuse simple with easy. It IS simple to reduce your weight. There are like, two things you need to do. It is, however, VERY hard to actually do those things.
But it's not. What you're referring to, is the basic concept of thermodynamic calorie in/calorie out. Yes, you can "just" reduce food and lose weight if you hit deficit numbers. But if you don't do it correctly, you'll feel like trash, you'll suffer bad cravings, and put yourself in a stressful mental situation for days, possibly putting your job at risk. You have to: - Eat less than what you're already eating - But…
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But you also take up resources, continue to decline physically, etc. We know that there is strong selection pressure for things that occur during reproductive years. No one debates this. How much the sort of scenarios you're discussing impact selection pressure is significantly less clear. But it's also a moot point for this discussion - we haven't been in a world where people can get this fat so easily and in such l…
Grandparents are a selective advantage well after reproduction. Older members of the tribe can watch the young while fitter members engage in hunting and foraging. They can also teach the young. Most tribes around the world that still exist you see this pattern.
But even if there is it doesn't mean that there is any reason whatsoever that increased GLP-1 production would be enough of an advantage to have had significant impact on evolution. We're going from A is true, B is likely true, C might maybe be true, all the way to Z is definitely true.
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wow people can just not be obese if they fix their habits! what a revelation! Better go tell all the obese people that, they surely have no idea.
Two things get in most people's way: nutritional knowledge and emotional control. Health and age is a factor for some ofc but can you honestly say that people know the nutritional value of what they're eating and also can emotionally control when they eat?
The apparent phenomenon of "free will" emerges from a chaotic, dynamic system, but you must understand the underlying variables if you want to effectively manipulate the result of their interactions.
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Obviously it’s not much easier or the drug wouldn’t be so valuable. People make such a moral crusade of this - the drug works, people will take it. Behavior modification works in theory and fails for most in practice. Even for those that can make it work usually don’t hold out indefinitely.
I made no moral statement. Behavior modification has worked great for several formerly obese people that I know. They made permanent lifestyle changes without relying on drugs. I really don't care whether people take weight loss drugs or not but the reality is that there are cheaper and safer alternatives.
We likely agree that doing it without drugs is probably better, but it’s definitely harder and it’s not clear yet how much better it will even be.
I’ve successfully lost 70lbs (250->180) three times and gotten fit, but it’s a constant effort and psychic drain to maintain the lower weight. If the drug (which I haven’t taken yet) made it easy that’d be a relief. It’s much easier to just manage exercise.
I suspect people that don’t have as much difficulty just get a different amount of joy from eating. For me I felt I could relate to the way an alcoholic described trying to quit drinking, except it’s harder in a way because you have to eat.
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Many people (will only speak to America), view being fat as a literal moral failing. Gluttony or overeating are not the sin, but being fat. (From that perspective:)a miracle cure that allows someone to stop being fat is like an indulgence (in the Roman Catholic sense). It’s a cheat, a shortcut that allows the unworthy to reach a state they do not deserve. My opinion is to wait long enough to validate there are no lon…
I'm not a Catholic, but wasn't the idea of an indulgence that God intentionally allowed an alternative path to redemption, such that if you buy an indulgence, you are (at least by their definition) worthy and deserving? I always thought of this as essentially the same idea as with Civ allowing you different paths to victory.
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The underlying mechanisms (reduced inflammation, improved fat distribution, better metabolic health) aren't unique to that group
> The underlying mechanisms (reduced inflammation, improved fat distribution, better metabolic health) aren't unique to that group Those are causes , you can't just invert it (again) and call them mechanisms for anti-aging... Those things are side effects of obesity and diseases causing obesity, there is no evidence or reasonable basis here to suggest there would be any "anti-aging" effect in healthy people without t…
More than 70% of Americans are overweight. That's a pretty overwhelming majority. Most of the Western world and significant portions of the Eastern world are trending in the same direction.
The point is that this can be generalized to a whole lot of people, not just those with HIV.
And there are other causes of inflammation besides just being overweight, and the GLP-1s reduce inflammation basically immediately, even with no weight loss.