Its not something that comes up every day at work, but it is still pretty often. For example, I was on a large team developing a complicated distributed system. The performance requirements were uncertain (like 500000 clients +- 200000, sending 10 +- 30 messages per second, etc). The system itself was in early development, hadn't been tuned, and we had only rough performance numbers for it.
Given only that, I needed to purchase the correct amount of hardware for the test lab, keeping in mind that the lead time for hardware was several months. I needed both statistics and some basic calculus to build a model based on what we knew, calculating variances for each intermediate and output, and then getting 50%, 90%, 99% confidence level estimates.
In the end, we got pretty close to a bullseye. On the other hand, I learned the important lesson to hide all the math from the client, lest they get awfully confused.