I never use password managers. The reason is simple: I don't want to rely on another software. If I had to remember 20 passwords I would and in fact I do carry around 10 different passwords in my head constantly. I trust my own brain rather more. And if my brain is comprised, what else can you do with all the security we have on our desktop?
1) Over the years it ends up being much more than 20 passwords. Bank accounts, credit cards, stock trading accounts, web servers, email accounts, IRA accounts, bitcoin passwords/keys, all kinds of work passwords, evernote, etc. I have more than 50 records in KeePass.
2) If you want secure passwords, they must be long (20 characters minimum) and random. Remembering something like that is nearly impossible for me. Once I started using KeePass, I feel way more secure than with my older scheme.