71–80 of 166 posts
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What’s exciting though is that this administration recently signed an executive order directing the agency to speed up the development and approval process for psychedelics.
Yup. Not sure which particular stopped-clock struck right within the generally anti-science MAHA movement but I think everybody is happy to take the win.
Make America Hallucinogenic Again?
This exact case study came up on a recent Rogan episode with Dean Radin, PhD. While the result is very interesting and perhaps illuminating about the unexpected biological mechanisms, apparently the effects were very short lived. Even more interesting, Dr. Radin discussed one of his companies is working on a new drug that uses the same brain receptors as psilocybin, that has the potential to induce similar effects (w…
I am immediately skeptical of anyone who goes on Rogan's show. Looking him up the guy has a PhD in education psychology, and his masters was in electrical engineering. I'm curious how much expertise he truly has on the subject and whether this was just spin for his company's work vs the natural option of psilocybin. Not that I doubt the benefit of a non-psychoactive treatment. Just the adjacency of this idea to Rogan…
He talked about how his whole career he just followed whatever was most interesting to him at the time, hence the different disciplines. He also talked about programs he ran at universities where he was in charge of bringing different disciplines together & the challenges of that since academia is incredibly siloed. Departments don’t talk to each other.
So I think people like him are very valuable, since they aren’t afraid to think it if the box, work on taboo subjects like “psychic” abilities, and see the universe in novel ways.
He mentioned they’ve done trials in mice and chimpanzees with very positive results. I’m not saying it’s some crazy breakthrough or anything, but it’s interesting and something worth keeping an eye on. It sounded also like the killer feature is the nasal delivery tech. I don’t think the are the first ones to study non psychoactive psilocybin like compounds, but the nasal delivery that can cross into the brain directly seemed important.
Earlier quoted context omitted.
What’s exciting though is that this administration recently signed an executive order directing the agency to speed up the development and approval process for psychedelics.
Yup. Not sure which particular stopped-clock struck right within the generally anti-science MAHA movement but I think everybody is happy to take the win.
Psychedelics are one of my favorite classes of drug. I used to take LSD recreationally every few weeks or months, until one bad vomiting episode caused me upper-esophageal sphincter dysfunction somehow. Ever since then, I can't seem to take any without throwing up (and generally having a terrible time due to stomach contents backing up into my throat constantly). Nobody can seem to figure out why my throat stopped wo…
>upper-esophageal sphincter dysfunction If you've never read a Pulitzer Prize Winner, Confederacy of Dunces would be a personally-relatable disaster (to start with; it's great). >Psychedelics are one of my favorite classes of drug. Your initial description of usage was probably a bit wreckless , but I do maintain that most people would probably benefit from a single (or few) psilocybin experiences (preferably an init…
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Ironically enough, the psychedelic field sort of defies some scientific analysis, so could be construed as "anti-science". I've seen some commentary that it's difficult to test. As an example, you can't really do a double blind study with a placebo because it's obvious to everybody who got the drug.
just because it's not double blind doesn't mean it's not science though. like idk, how do you do double blind studies of astronomical phenomena?
It's also true that people in the psychedelic world talk about non-reproducible aspects of the trip quite a bit. "Set and setting" and so forth.
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When you take it, you understand, that if taken with the right approach it can lead to profound insights in changing your life and the effects described: helping with depression, addiction and accepting death are not far fetched at all. Yet it can also, if not guided or done on someone with anxiety have the opposite effect. The more biological effects I agreed are not conclusion that can be drawn from that.
> When you take it, you understand To be fair, this is not how medical research is done.
It's great if we have therapies that help people and get a proper scientific stamp. Yet we can also discover the benefits for ourselves before that stamp is given.
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>upper-esophageal sphincter dysfunction If you've never read a Pulitzer Prize Winner, Confederacy of Dunces would be a personally-relatable disaster (to start with; it's great). >Psychedelics are one of my favorite classes of drug. Your initial description of usage was probably a bit wreckless , but I do maintain that most people would probably benefit from a single (or few) psilocybin experiences (preferably an init…
Microdosing has very limited evidence to support it, and even mode widely varying claims for what it supposedly helps with.
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It might be coincidence. Hiatal hernia affects more than 50% of the population over age 50, though not everyone shows symptoms.
Ever since that episode I've had difficulty swallowing; sometimes when clearing my throat the air will unexpectedly blow out my mouth instead of my nose; and I also have to be doing that constantly because my throat never actually feels clear now; it sucks. I used to be able to swallow gummy bears whole for fun. Or any medication, even huge pills (1g magnesium glycinate, for example -- those pills are not small) -- I…
One weird trick to try is a "heel drop": https://www.modernapothecary.org/blog/the-healing-power-of-h... Even if you don't have a hernia, it can't hurt to try it; you can even do it accidentally by drinking a sports drink and then jogging around the block. I was shocked to find it ended an awful bout of laryngopharyngeal reflux. (I had a scan long ago that incidentally observed a sliding hiatal hernia, but I didn't have symptoms for many years.)
In any event, I'm sorry you're having this trouble, and I hope it resolves itself.
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That's a silly statement. There's been plenty of people who went on there to try to talk sense into him.
Rogan is obviously pro psychedelics, and was even featured in the oval office during the recent Ibogaine approval signing. I think it's worth noting if this N=1 "study" has any association with such an obviously biased and influential individual.
Dismissing this "study" (really a case file) because of the N=1 and the shady journal seems like a stronger position than bringing in Rogan. Talking about Rogan just looks like partisan posturing.