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Venom and hot peppers offer a key to killing resistant bacteria

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71–80 of 92 posts

Re: Venom and hot peppers offer a key to killing resistant bacteria

#71
post #16

If you’ve ever wondered why the symbol of health is a snake spiraling a staff (the Greek god Asclepius’s staff to be specific), it’s because in Ancient Greece they used small amounts of snake venom to treat serious illnesses We’ve come full circle

I always assumed what I felt was obvious: Numbers 21:4-9, where God instructs Moses to make a bronze serpent and place it on a pole to heal Israelites dying from poisonous snake bites.

But the symbol is explicitly non-abrahamic in origin…

Re: Venom and hot peppers offer a key to killing resistant bacteria

#72

If you’ve ever wondered why the symbol of health is a snake spiraling a staff (the Greek god Asclepius’s staff to be specific), it’s because in Ancient Greece they used small amounts of snake venom to treat serious illnesses We’ve come full circle

It seems that it's quire more complicated than that. https://en.wikipedia.org/wiki/Caduceus_as_a_symbol_of_medici...

I thought the predominant one was: https://en.wikipedia.org/wiki/Rod_of_Asclepius

Re: Venom and hot peppers offer a key to killing resistant bacteria

#73
post #15

If you’ve ever wondered why the symbol of health is a snake spiraling a staff (the Greek god Asclepius’s staff to be specific), it’s because in Ancient Greece they used small amounts of snake venom to treat serious illnesses We’ve come full circle

I thought it’s a stick to pull out a tape worm. You wrap it around the worm and keep twisting to get it out.

And then you have a ready-made worm kabob, ready to roast and eat! Infinite food exploit unlocked.

Re: Venom and hot peppers offer a key to killing resistant bacteria

#74

"Researchers have developed", yeah. When I read such things, I always recall https://en.wikipedia.org/wiki/Epimerox - this thing promised wonders - very broad spectrum, very low toxicity - and, most importantly, it was targeting a conservative essential protein - so nearly zero resistance. And there were no updates for more than a decade. Something developed in a lab is something we, most likely, will never see - and…

This story actually checks out, which is quite the condemnation of our American drug development system. One thing bugs me though - why don't other countries with different research structures pick this up and run with it?

American salaries and research funding are way bigger. The best scientists around the world have a strong incentive to emigrate. And the ones who don't, can't do much with the scarce funds they have, compared to America.

Re: Venom and hot peppers offer a key to killing resistant bacteria

#75
post #17
post #6

Earlier quoted context omitted.

We also recently (we think) discovered why acupuncture works. That form of medicine from 4000 years ago...

There’s also electroacupuncture, which is gaining popularity in physical therapy clinics in the US. > Like traditional acupuncture, electroacupuncture uses needles placed in the same spots. Then, a small electrode is attached to the needles. A small amount of electricity runs through the electrode and gives a slight vibration or soft hum during treatment. (1) Since they use the same spots as traditional acupuncture e…

Your reference seems to be about CBD, not "electro acupuncture"

Re: Venom and hot peppers offer a key to killing resistant bacteria

#76
post #58
post #55

Earlier quoted context omitted.

Maybe you should not omit those "dozens of words" that clearly explain what you're trying to portray as a contradiction. > These molecules have a particular property: When they come into contact with air, they oxidize and change color. One becomes blue and the other red.

You are absolutely right. Maybe I shouldn't. But then I have to deep-dive into yet another flagrant cheap hallucination. You see, when a molecule oxidize , it becomes a different molecule. It is impossible for a benzoquinone to oxidize, yet remain a benzoquinone. There are just two of them [1], and the two are isomers [2]. Transforming one into another would be isomerisation, not oxidation. Not to mention — "oxidize…

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Re: Venom and hot peppers offer a key to killing resistant bacteria

#77
post #51

Earlier quoted context omitted.

I've been doing this for like two years now and see no adverse effects, but that is just me.

I would be worried about long term damage. In 10 years you might be in a world of hurt from this. At the very least I would let your doctor know that you are doing this and see what they think of it.

If your intestinal lining is healthy, there's probably not much to worry about.

If it hurts while just sitting in your gut that's probably a red flag that something about your digestive system is off.

Re: Venom and hot peppers offer a key to killing resistant bacteria

#78
post #60

I imagine the long term solution to antibiotic resistance are engineered bacteriophages, either to directly attack the bacteria or to insert genes that make the bacteria susceptible to specific agents. Beyond not having to continuously develop new antibiotics or restrict treatment, these could also be much more targeted treatments with less harmful effects on a patient's microbiome. Of course scaling up to mass produ…

But bacteria also become resistant against phages, you would still have to continuously develop new ones.

I have no idea if this is true, but I remember seeing in a Kurzgesagt video that developing phage resistance reduces antibiotic resistance, and vice versa. So you might corner bacteria by using both.

https://www.youtube.com/watch?v=YI3tsmFsrOg&t=5m18s

Re: Venom and hot peppers offer a key to killing resistant bacteria

#79
post #61
post #16

Earlier quoted context omitted.

I always assumed what I felt was obvious: Numbers 21:4-9, where God instructs Moses to make a bronze serpent and place it on a pole to heal Israelites dying from poisonous snake bites.

Sorry but the bible is not a historic document. If you want to read old texts a bit more grounded in reality try the Kama Sutra ... ;)

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Re: Venom and hot peppers offer a key to killing resistant bacteria

#80
post #60

I imagine the long term solution to antibiotic resistance are engineered bacteriophages, either to directly attack the bacteria or to insert genes that make the bacteria susceptible to specific agents. Beyond not having to continuously develop new antibiotics or restrict treatment, these could also be much more targeted treatments with less harmful effects on a patient's microbiome. Of course scaling up to mass produ…

But bacteria also become resistant against phages, you would still have to continuously develop new ones.

Improving phages is dramatically easier - you can just modify an existing one, either through direct engineering or by evolution, rather than having to find a brand new chemical that conveniently does what you want without serious negative drawbacks. 20 years ago the difficulty may have been comparable but the engineering tools for creating synthetic phages have advanced extremely rapidly.

And particularly if you are introducing a vulnerability instead of directly attacking the bacteria with the phage, there is no evolutionary pressure to become resistant until the phage has already done its job. You can even go further and have it insert genes that confer an advantage in addition to the susceptibility, so that even if some of the bacteria are by chance naturally resistant to the phage they get outcompeted prior to the deployment of the killing agent.

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