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Nuclear receptor 4A1 linked to health effects of coffee: study

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Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#71

Post by papyrus9244 »

jorvi wrote: post #47
Bridged7756 wrote: post #27

I love coffee. It's good for you, it smells and tastes so good. It wakes you up, and prevents sleepiness after meals. Its stimulant nature is a plus, but not necessarily the main thing.

Unfortunately the most flavorful methods (espresso, french press, moka) also raise your cholesterol. So sadly, no, coffee is not universally "good for you". Filtered coffee methods are though, as the filter absorbs the oils.

If something has several clear positive effects, and a possible small, arguably irrelevant, negative effect, most people will agree that yes, it's good for you.

It's like trying to argue that running may have a negative effect on some people's meniscus under some specific circumstances. That doesn't negate the generalization "running is good for you".

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#72

Post by m3kw9 »

jorvi wrote: post #47
Bridged7756 wrote: post #27

I love coffee. It's good for you, it smells and tastes so good. It wakes you up, and prevents sleepiness after meals. Its stimulant nature is a plus, but not necessarily the main thing.

Unfortunately the most flavorful methods (espresso, french press, moka) also raise your cholesterol. So sadly, no, coffee is not universally "good for you". Filtered coffee methods are though, as the filter absorbs the oils.

Pour over is flavorful and none of the fat

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#73

Post by panabee »

panabee wrote: post #48

Here are more fascinating facts about caffeine and cancer. Caffeine affects the immune system via at least two opposing mechanisms. Mechanism 1: A2A receptor antagonism (immunostimulatory) Tumors and damaged tissues release adenosine, which engages the A2A receptor on immune cells and signals them to stand down. Caffeine antagonizes (i.e., blocks) this receptor. Mechanism 2: Raising intracellular cAMP (immunosuppress…

On second thought, I will publish something regardless of interest.

It will be an "Cancer for Engineers" framework, delivered via free, open-source Custom GPTs and Claude Skills. (Gemini gems are less reliable in our experience.)

The goal: to ease engineers into cancer via AI personalized introductory curriculums with varying time commitments to enable deeper independent investigation or fast exits if interest wanes: 4 hours, 8 hours, 12 hours.

Basically 1-3 hours per week for a month.

The reason I think some engineers may find cancer interesting, aside from the societal impact:

The human body is like a complex operating system. Cancer is a severe runtime error. Tracing root causes -- like genetic mutations, signaling errors, or immune evasion -- has many parallels to diagnosing system failures.

BTW if anyone from Kaggle/GDM is reading this, we are having issues submitting a benchmark paper for NeurIPS based on the Kaggle Benchmark.

Google models seem to get a different scheduling priority, ironically, enough and take >20 hours to complete a benchmark task that other models like Opus 4.6 finish in <1 hour -- same code path, same task. Would love help if possible since the abstract deadline is Monday (It's last minute because we didn't originally plan to submit this, but someone suggested it.)

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#74

Post by [deleted] »

panabee wrote: post #48

Here are more fascinating facts about caffeine and cancer. Caffeine affects the immune system via at least two opposing mechanisms. Mechanism 1: A2A receptor antagonism (immunostimulatory) Tumors and damaged tissues release adenosine, which engages the A2A receptor on immune cells and signals them to stand down. Caffeine antagonizes (i.e., blocks) this receptor. Mechanism 2: Raising intracellular cAMP (immunosuppress…

[deleted]

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#75

Post by xyhopguy »

panabee wrote: post #73
panabee wrote: post #48

Here are more fascinating facts about caffeine and cancer. Caffeine affects the immune system via at least two opposing mechanisms. Mechanism 1: A2A receptor antagonism (immunostimulatory) Tumors and damaged tissues release adenosine, which engages the A2A receptor on immune cells and signals them to stand down. Caffeine antagonizes (i.e., blocks) this receptor. Mechanism 2: Raising intracellular cAMP (immunosuppress…

On second thought, I will publish something regardless of interest. It will be an "Cancer for Engineers" framework, delivered via free, open-source Custom GPTs and Claude Skills. (Gemini gems are less reliable in our experience.) The goal: to ease engineers into cancer via AI personalized introductory curriculums with varying time commitments to enable deeper independent investigation or fast exits if interest wanes:…

cancer is more like debugging a gigantic DL model than an operating system. spaghetti of redundancies all the way down.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#76

Post by risyachka »

didgeoridoo wrote: post #9
obsidianbases1 wrote: post #7

Earlier quoted context omitted.

Are you familiar with the process of extracting the caffeine in decaf? Unfortunately it isn't without potential downsides.

Supercritical CO2 extraction is pretty innocuous. Just buy good decaf from a place that doesn’t bathe their beans in toxic waste.

Right? All high quality coffee makers use a proper method so there is absolutely zero downside in decaf. Just make sure to check which method they use (all big ones state it on their website or else)

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#77

Post by ai_slop_hater »

nemomarx wrote: post #21
ai_slop_hater wrote: post #16

Earlier quoted context omitted.

[flagged]

Why? Coffee tastes good. What's wrong with drinking something that you like the taste of, or just a warm drink in general?

There is nothing objectively wrong with drinking something you like the taste of, however, when it is coffee specifically, I believe, the utility of it is the caffeine it contains; that, and the culture around coffee-drinking makes me feel the way I described. Notice the "in my humble opinion" at the end of my message.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#78

Post by nemomarx »

ai_slop_hater wrote: post #77
nemomarx wrote: post #21

Earlier quoted context omitted.

Why? Coffee tastes good. What's wrong with drinking something that you like the taste of, or just a warm drink in general?

There is nothing objectively wrong with drinking something you like the taste of, however, when it is coffee specifically, I believe, the utility of it is the caffeine it contains; that, and the culture around coffee-drinking makes me feel the way I described. Notice the "in my humble opinion" at the end of my message.

If the utility of it was the caffeine, what would the audience for decaf be? It should be plain that the other aspects are also important.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#79

Post by bigyabai »

ai_slop_hater wrote: post #77
nemomarx wrote: post #21

Earlier quoted context omitted.

Why? Coffee tastes good. What's wrong with drinking something that you like the taste of, or just a warm drink in general?

There is nothing objectively wrong with drinking something you like the taste of, however, when it is coffee specifically, I believe, the utility of it is the caffeine it contains; that, and the culture around coffee-drinking makes me feel the way I described. Notice the "in my humble opinion" at the end of my message.

> that, and the culture around coffee-drinking makes me feel the way I described.

Then why identify with it at all? You would be happier taking caffiene pills or drinking an Arnold Palmer, it sounds like.

Re: Nuclear receptor 4A1 linked to health effects of coffee: study

#80

Post by reactordev »

jayd16 wrote: post #25
technothrasher wrote: post #5

"While caffeine is the major individual component of coffee, the study suggests that it may not be the primary driver of these health effects." All you haters that give me grief for drinking my daily cup of decaf can shut up now.

The decaf tries to warn you itself with its bright carafe colorings. In nature that means "Do not touch me, I am poison."

except on packaging which means "Buy me, I'm sugar".
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