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Notes from the SF peptide scene

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Re: Notes from the SF peptide scene

#71

Post by cjbgkagh »

trillic wrote: post #69
cjbgkagh wrote: post #46

Earlier quoted context omitted.

The state is already heavily involved, many gray market peptide suppliers were shut down this year, but demand just went to the black market. This would be harder to stop than the illicit drug market that the government has also consistently failed to stop. It’s so cheap that I’ve stockpiled many years supply so there is little worry about lack of availability for whoever needs it. I turned to peptides because of how…

What are the peptides you're using for hEDS?

BPC157/TB5, IPA/CJC-NoDac, VIP, and Semaglutide (ozempic). Semaglutide was the most effective long term for autoimmune but the others really helped with CCI and other physical ailments. I take a combo of modafinil in the morning and amitryptiline at night as a treatment for dysautonomia and dopamine dysregulation. I started Low Dose Naltrexone and supplemental T3 hormone and this is a good place for most with hEDS to start with.

Re: Notes from the SF peptide scene

#72

Post by sharadov »

I think those days of "high sincerity" and trying to change the world are long gone and replaced by "high charlatanism" and making a killing.

I don't blame them - the collective optimism about AI has been replaced by paranoia.

So everyone is trying to make a fast buck before the music dies.

Re: Notes from the SF peptide scene

#73

Post by [deleted] »

Aurornis wrote: post #6

This article is an anecdote extrapolated to something bigger: A type of lazy writing where the writer has a single social experience with a group of weird people and then writes about it like it’s the common experience in a place. The writer went to SF for a few days and went to one party where a group of friends were into peptides. From the article, they were also particularly terrible people. Just read this quote:…

[deleted]

Re: Notes from the SF peptide scene

#74

Post by dw_arthur »

Injecting unregulated chemicals into your body is something you may regret in the future. If you inject a Chinese peptide to improve your sleep quality score and three years later you're diagnosed with cancer the inscrutable nature of causality in the body may drive you mad.

Re: Notes from the SF peptide scene

#75

Post by Ifkaluva »

I think a lot of folks are taking this more seriously than the author intended. He opens the post by referencing Scott Alexander’s famous satirical pieces “Bay Area House Party”, and places himself within that satirical frame by insisting those are real.

By analogy with “Bay Area House Party” stories, this piece intends to pick up on some of the wackiest new ideas in SV and extrapolate them to the point of ridiculousness. Go read Scott Alexander’s versions for context. One example is a conservative man moves to Oakland, observes that statistically most kids grow up transgender, decides to raise his daughter as a boy, so when they hit their teenage years they will “transition” gender into their birth gender. Another example is when the visitor to the Bay Area house party is talking to several people, each of which has an increasingly insane startup idea, always funded by Peter Thiel. Another is a house party organized by Claude Code, which everything is superficially sensible but totally insane LLM hallucinations when you look more closely.

Re: Notes from the SF peptide scene

#76

Post by cryzinger »

mh2266 wrote: post #50

WTF is any of this, is there some ELI5/OOTL explanation? I work in big tech and have never heard anyone talk about "peptides". Is this a startup scene thing or just an SF thing? (I live in New York) all of my coworkers are pretty normal, sure there are the stereotypical fitness types that are marathon training, cycling, or have a climbing gym membership but no one is talking about buying weird Chinese drugs

This recent NYer article is a pretty good overview, written by a practicing physician:

https://www.newyorker.com/magazine/2026/04/13/why-are-people...

Re: Notes from the SF peptide scene

#77

Post by temp8830 »

rexpop wrote: post #62
adregan wrote: post #19

I’m not really understanding the notion that these people are so sincere. Perhaps we have different definitions of sincerity. To my eye, the entire fascination of unsafely injecting peptides in a desire to change your being is largely the opposite of sincerity.

> If a 14 year old says that they are going to change the world, they are being very sincere even if an ‘adult’ knows that the likelihood is low. No, it's really a form of sincerity permitted by a sort of willfully affected naivete—adopted in pursuit of the strategy of Twain's amateur: > The best swordsman in the world doesn’t need to fear the second best swordsman in the world; no, the person for him to be afraid of…

> Only one amateur in my portfolio need "catch" the incumbent "out".

The rest can live out the rest of their short degenerate lives as the failed experiments that they are. This does however have the side effect of turning the entire town into a society of failed degenerates...

Re: Notes from the SF peptide scene

#78

Post by CatMustard »

cyanydeez wrote: post #41
dkarl wrote: post #30

Earlier quoted context omitted.

I don't think that's the way you're supposed to read it? I think you're supposed to read it as, the trendy extremes tell you something about a place, even if the details are silly and ephemeral. People with no filter, no shame, no interest in correctness or consequences, and no pole star except trends are like a cartoon guide to the trends and the mentality driving them. I think the author would agree with most of wh…

the last decade of journalism has taken two comments on twitter to claim social zeitgeist.

Maybe in a world as culturally-fractured as ours two comments on twitter is as close to a zeitgest as you can get.

Maybe. Personally I'd say it'd take at least 5.

Re: Notes from the SF peptide scene

#79

Post by baq »

cjbgkagh wrote: post #17
Aurornis wrote: post #6

This article is an anecdote extrapolated to something bigger: A type of lazy writing where the writer has a single social experience with a group of weird people and then writes about it like it’s the common experience in a place. The writer went to SF for a few days and went to one party where a group of friends were into peptides. From the article, they were also particularly terrible people. Just read this quote:…

They did point out, with numbers, that the SF scene is a lot smaller than would ordinarily be expected. Additionally this is the party scene which is a subset of the general tech scene. These people have more time and money to spare than those who are busy working but they do form a bit of a nexus that channels information. The blog post seems to go to great lengths not to pretend that it is something that it isn’t.…

> They did point out, with numbers, that the SF scene is a lot smaller than would ordinarily be expected.

‘Assuming no correlation’.

In reality the correlation is probably an epsilon away from 1 in this case.

Re: Notes from the SF peptide scene

#80

Post by ericskiff »

AstroBen wrote: post #43
Aurornis wrote: post #6

This article is an anecdote extrapolated to something bigger: A type of lazy writing where the writer has a single social experience with a group of weird people and then writes about it like it’s the common experience in a place. The writer went to SF for a few days and went to one party where a group of friends were into peptides. From the article, they were also particularly terrible people. Just read this quote:…

> What’s not talked about is the long-term consequences of falling into these groups where excessive drug self-experimentation is normalized. Lots of people from the 2010-ish era of "aesthetics" and steroids are having heart issues now in their 30s (or earlier). Pretty sad to see. To me it's fairly clear where this comes from: ambitious people convinced they've figured out some secret cheat code that no-one else has.…

That comment seemed to revolve around consent. Willful, nonconsensual dosing of anyone with any drug is a violation, and yes doing it and bragging about it is reprehensible.
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