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Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)
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Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)
#72Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)
#73Earlier quoted context omitted.
If the doses of cannabis required to cure alzheimers would be high enough doses to destroy the rest of one's brain, it makes this finding not very useful, similar to the idea of curing alzheimers by destroying one's brain/
Synthetic cannaboids were also studied as a possible analgesic and at the doses required it caused brain damage. Which is honestly disappointing because a general purpose pain killer that isn't opioid based would be a miracle.
What are your issues with opioid-based painkillers?
Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)
#74Earlier quoted context omitted.
I've tried everything and I still get panic attacks. I used to love smoking a small hitter about an hour before bed. I've always had insomnia and that was the one thing that actually helped me sleep. When it was illegal, I loved it. I would smoke 2 or 3 times a week just for sleep, and I was healthy and happy. . . Because sleep is important, and I never wanted to take sleeping pills because dependency. Now that it's…
Have you tried edibles or another method than smoking?
I have not done weed for ages, but while smoking would always give me anxiety, vaping much less so.
Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)
#75Earlier quoted context omitted.
Can you explain the joke?
If the doses of cannabis required to cure alzheimers would be high enough doses to destroy the rest of one's brain, it makes this finding not very useful, similar to the idea of curing alzheimers by destroying one's brain/
But the studies are pervasive. For example, the (flawed) study that found that one cup of wine with each meal was healthier that no alcohol at all is still quoted today, and still "reproduced" in other studies that make the same claim but adding a clause of "given that you also [do good amount of exercise|eat very healthy|are in perfect health already]". Or the flawed studies that Soffriti and Belpoggi pushed (some of them didn't even pass peer review, but reached the public anyway) about artificial sweeteners and other things being carcinogenic: they basically feed mices with whatever they feel until they die, they look the corpses and if there is a tumor, eureka: what they put in the diet is the cause. Nobody took the studies seriously, except the public that now have a "scientific paper" that says Coca-cola causes breast cancer.
In this case some public reads "smoking a joint daily equals invulnerable to Alzheimer, science says so".
Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)
#76Earlier quoted context omitted.
If the doses of cannabis required to cure alzheimers would be high enough doses to destroy the rest of one's brain, it makes this finding not very useful, similar to the idea of curing alzheimers by destroying one's brain/
Synthetic cannaboids were also studied as a possible analgesic and at the doses required it caused brain damage. Which is honestly disappointing because a general purpose pain killer that isn't opioid based would be a miracle.
although the study is often labelled irreplicable, i do still believe in rat park. opiates are not evil in and of themselves; rather, society forms a structure around which the use of opiates easily becomes more alluring than contributing to said society. consequently, those in chronic pain are often forced to suffer needlessly by being deprived of relief, so that societal productivity is maximized. the real miracle would be a fixed system, not the novel non-opiate painkiller suzetrigine. but apparently that is the next best thing.
Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)
#77Earlier quoted context omitted.
There may not be many constants in this life, especially in this day and age, but I do find it humbling that "there is always an xkcd for that" holds true.
...is there an XKCD relevant to the fact there's always a relevant XKCD?
Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)
#78Earlier quoted context omitted.
We have dozens of pain killers which are not opioid based, what do you mean? From the top of my head NSAIDs can be used, and Metamizole for example is as effective as morphium.
you got nsaids, metamizole, acetoaminophen, duolexitine. And you got a couple of more that work for neuropathic pain. The biggest problem with nsaids is that they cause bleeding and kidney failure, ulcers hence can cause stomach cancer. Here is a site you can use too see how most pharmaco therapy is lacking. https://pain-calculator.com/calculators/osteoarthritis-pain/
Yes.
Very few painkillers that are not blood thinners. Paracetamol and canabinoids are a couple of rare exceptions.
My uncle broke his hip in his old age. He died shortly after because of the bleeding induced by painkillers.
Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)
#79I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in the 0.1uM range and then taking off in the 1uM range. I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in…
I suppose this might be why Willie Nelson is still doing pretty good these days...
You might have replied to the wrong comment. OP implied it would have no impact
Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells (2016)
#80[dead]