Earlier quoted context omitted.
Sadly, Excel and the dumbness of the environment generated disasters on Genomics (and tons of other research areas too) causing millions if not billions of losses. Hint: skewed experiments/data and so on, making years of effort worthless. That woudn't happen under BioPython/BioPer/Rl and a custom dedicated interface with no data mangling at all. Poeple in the 90's joked about how MS turned the whole IT industry 20 ye…
You're forgetting that Excel is the most ergonomic programming language in the world, full stop, nothing else even comes close. Until it's as easy to build something with those other things as it is to whip up a sheet in Excel, they're not leaving the starting gate when it comes to usage, especially by people who are not professional software devs
The most ergonomic programming environment in the world today it's a mix between a notebook and a REPL with live changes. Something like a cross between Smalltalk and Jupyter, and that doesn't exist yet. Org-mode for Elisp it's close as it allows you to do literate programming, a REPL and such in a 'live' and documented way.