71–80 of 165 posts
Am I misunderstanding the headline? Is the word "block" now meaning "enhance" instead of "stop"? I would think based on the text of the article that it enhances resistance. Or are tumors necessary to stop cancer growth (even though it is cancer growth?)
Yes, what’s being blocked is “tumor resistance” to treatment.
“potentially overcoming treatment resistance in one of the deadliest cancers.”
IN MICE. (To be fair, also IN SOME OTHER BETTER MICE). https://jamesheathers.medium.com/in-mice-explained-77b61b598... (mostly a joke, but I'd be in favor of adding context to the HN headline if possible)
This isn't quite as bad as the garden variety "in mice" studies: > The combination therapy also led to significant regression in genetically engineered mouse tumours and in human cancer tissues grown in lab mice, known as patient-derived tumour xenografts (PDX).
I've been playing to much pokemon with my kids, read this as "Dugtrio"
there must be some sort of word for "games-bleeding-into-real-life" for stuff like this. I remember years ago playing some games, and hearing similar sounds in real life would startle (or amuse) me. And you can't really explain it to anyone around you, lol.
Earlier quoted context omitted.
That's not what the prisoner’s dilemma is.
Yeah this is more like a Pascalian Gamble [1]. If you try nothing, then you are assured to die as God wanted. If you try something , then you might live, but then God hates you. [1] https://en.wikipedia.org/wiki/Pascal%27s_wager
> Clinical implications: While more research will be needed before trials in humans can begin Why? Seriously, think about it. Most people with pancreatic cancer have nothing to lose and many of them have just weeks or months to live. Daraxonrasib, Afatinib, and SD36 are molecules that can already be purchased in bulk, and what's the worst that can happen? Our society's morbid, irrational fear of quack medicine causes…
The patient dies from complications of the drug's use before the cancer.
> Clinical implications: While more research will be needed before trials in humans can begin Why? Seriously, think about it. Most people with pancreatic cancer have nothing to lose and many of them have just weeks or months to live. Daraxonrasib, Afatinib, and SD36 are molecules that can already be purchased in bulk, and what's the worst that can happen? Our society's morbid, irrational fear of quack medicine causes…
> Clinical implications: While more research will be needed before trials in humans can begin Why? Seriously, think about it. Most people with pancreatic cancer have nothing to lose and many of them have just weeks or months to live. Daraxonrasib, Afatinib, and SD36 are molecules that can already be purchased in bulk, and what's the worst that can happen? Our society's morbid, irrational fear of quack medicine causes…
For all the folks complaining about "it's only in mice! things never work in humans!" -- I work at MSK and we definitely have seen success treating PDAC in humans: https://www.nature.com/articles/s41586-023-06063-y "Why don't I see these treatments hitting the general public?" Because trials like these are phase I/II. Then you need a phase III that takes a long time to recruit a large cohort and has overall survival…
What's MSK?
It's funny how many years of "X found to be effective in fighting cancer" stories have filtered through HN and then you never hear about it again. The research at treating mouse cancer has been making great strides--people cancer still has a long way to go though.
People cancer outcomes have improved a lot in recent decades. Many forms of cancer are essentially cured if you detect them early enough.
> Clinical implications: While more research will be needed before trials in humans can begin Why? Seriously, think about it. Most people with pancreatic cancer have nothing to lose and many of them have just weeks or months to live. Daraxonrasib, Afatinib, and SD36 are molecules that can already be purchased in bulk, and what's the worst that can happen? Our society's morbid, irrational fear of quack medicine causes…
> what's the worst that can happen? The patient dies from complications of the drug's use before the cancer.