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Weight loss jabs: What happens when you stop taking them

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Re: Weight loss jabs: What happens when you stop taking them

#71

Post by paulpauper »

iwanttocomment wrote: post #35

We need to start looking at obesity as a hunger disorder, and not as the result of an addiction, a lack of knowledge about nutrition, or a lack of self control. When an obese person regulates their eating and loses weight, the hunger often doesn't go away - and often increases. This is physical, not psychological hunger. When the obese person almost inevitably returns to eating to fullness, they regain weight. When a…

In many obese people, the hunger is present even when they eat a nutritious meal at the appropriate number of calories to maintain their weight. Common advice is to say "this mix of macros or foods makes me satisfied!" and, well, that's great for you but not universal.

Yup..the high failure rate of dieting is true regardless of the type of food or the macros. Lecturing to 'just eat healthy' as the default mode of advice does not work for the large majority of obese people..this is supported by the literature and anecdotal evidence.

Re: Weight loss jabs: What happens when you stop taking them

#72

Post by afavour »

AaronAPU wrote: post #53
afavour wrote: post #45

Earlier quoted context omitted.

How can you say that with any certainty, though? How do you know that hunger hits you in the exact same way it does another person? That overcoming it requires the exact same amount of willpower in all people?

My hunger feels 8 trillion times worse than an obese person’s. Since I am making the claim, everyone else has to affirm it now.

But you’re disproving your own point. Other people’s experiences aren’t knowable so you can’t say it’s just a willpower issue.

Re: Weight loss jabs: What happens when you stop taking them

#73

Post by toyg »

paulpauper wrote: post #52
filoleg wrote: post #41

Earlier quoted context omitted.

> It feels like gaining weight is incredibly easy and losing it is incredibly hard I feel like there is more to it. Obviously, I sympathize with you, and I noticed that when I switch from a bulking cycle to a cutting cycle, it is a bit difficult to adjust for the first couple of weeks as well. But by god, I truly am struggling to switch the other way around, and it takes me months to adjust to the bulking cycle, even…

But by god, I truly am struggling to switch the other way around, and it takes me months to adjust to the bulking cycle, even with the help of stuff like weed You could just have good genetics in which your body is resistant to weight gain or you have a low appetite to begin with. As shown by the worldwide obesity epidemic, this is apparently quite an uncommon problem. 75% of country overweight or obese.

> good genetics

This moral judgement whereby losing weight is "good" in absolute, is such bullshit. For most of history, humans have fought starvation literally every day, and often had to make do with minimal caloric intake for weeks or months - in that context, genetics that kept you thin were definitely very bad.

Re: Weight loss jabs: What happens when you stop taking them

#74

Post by refibrillator »

Taikonerd wrote: post #12

Interesting link: a company called Fractyl Health is studying a surgical procedure they call "Revita," that they hope can keep weight off for patients after they discontinue GLP-1s.[0] The premise, IIUC, is that obesity is driven partly by mucosal overgrowth on the duodenum. This thicker-than-expected layer of mucus is less porous, which leads your digestive system to underestimate the number of calories you've consu…

Fascinatingly, the body already has a mechanism for this: fasting. One of the many beneficial side effects is rapid mucosal atrophy, decreasing villus height and crypt depth.

You can find evidence of this in the literature, but it’s absurdly understudied, because big pharma would rather sell you a subscription to life.

Fortunately there are many good people in the world, especially in the field of medicine, who want to help their patients unconditionally. So there are glimmers of hope, like some of the top cardiologists in the world going against status quo and treating patients with fasting regimes instead of surgery.

Re: Weight loss jabs: What happens when you stop taking them

#75

Post by 3rodents »

AaronAPU wrote: post #33
jmward01 wrote: post #8

Other medications become lifelong medications but without this level of scrutiny. I am 100% in favor of finding a more permanent treatment, but switching blood pressure meds, and cholesterol meds, and other daily meds for a single once a week med is a massive improvement, especially since the all source mortality data keeps rolling in showing the efficacy here is orders of magnitude better than all the other medicati…

But it is factually true that it’s a matter of willpower, no amount of reframing it is going to change that. It’s not like others like myself, currently on a cut cycle, don’t experience hunger. The idea that we are just “lucky” ignores all the willpower and discipline we fight through to do it ourselves. I’ve eaten about 800 calories today and it is 4pm. Just finished 90 minutes on the indoor bike. My stomach feels h…

People are different. Using your own achievements as evidence of other’s failings isn’t useful, we are all different. I can fast for 23 hours a day, 365 days a year (omad) with ease, not because I have more willpower than my fat friends, but because I’m different. My fat friends are objectively stronger and more resilient than me in almost every aspect of life, yet by your measure, because hunger doesn’t bother me, I have more willpower than them? Willpower isn’t measured on outcomes.

Re: Weight loss jabs: What happens when you stop taking them

#76

Post by [deleted] »

Taikonerd wrote: post #48
hamandcheese wrote: post #29

Earlier quoted context omitted.

> Revita basically re-surfaces the duodenum. Does this reduce mucous production going forward? Otherwise, it seems like it would be a temporary effect.

My impression (and I'm not a scientist) is that the mucosal overgrowth comes from eating an obesogenic diet. (Some combination of too much sugar / salt / wrong types of fat?) If you get the procedure and don't go back to an obesogenic diet, then it should be permanent.

[deleted]

Re: Weight loss jabs: What happens when you stop taking them

#77

Post by paulpauper »

toyg wrote: post #73
paulpauper wrote: post #52

Earlier quoted context omitted.

But by god, I truly am struggling to switch the other way around, and it takes me months to adjust to the bulking cycle, even with the help of stuff like weed You could just have good genetics in which your body is resistant to weight gain or you have a low appetite to begin with. As shown by the worldwide obesity epidemic, this is apparently quite an uncommon problem. 75% of country overweight or obese.

> good genetics This moral judgement whereby losing weight is "good" in absolute, is such bullshit. For most of history, humans have fought starvation literally every day, and often had to make do with minimal caloric intake for weeks or months - in that context, genetics that kept you thin were definitely very bad.

Having a smaller appetite could have been advantageous by allowing food to last longer

Re: Weight loss jabs: What happens when you stop taking them

#78

Post by yread »

refibrillator wrote: post #74
Taikonerd wrote: post #12

Interesting link: a company called Fractyl Health is studying a surgical procedure they call "Revita," that they hope can keep weight off for patients after they discontinue GLP-1s.[0] The premise, IIUC, is that obesity is driven partly by mucosal overgrowth on the duodenum. This thicker-than-expected layer of mucus is less porous, which leads your digestive system to underestimate the number of calories you've consu…

Fascinatingly, the body already has a mechanism for this: fasting. One of the many beneficial side effects is rapid mucosal atrophy, decreasing villus height and crypt depth. You can find evidence of this in the literature, but it’s absurdly understudied, because big pharma would rather sell you a subscription to life. Fortunately there are many good people in the world, especially in the field of medicine, who want…

Do you have some good links for that? I only found this

https://www.mdpi.com/2072-6643/16/1/128

which says that the changes reverted quickly after resuming normal feeding

Re: Weight loss jabs: What happens when you stop taking them

#79

Post by toomuchtodo »

Taikonerd wrote: post #12

Interesting link: a company called Fractyl Health is studying a surgical procedure they call "Revita," that they hope can keep weight off for patients after they discontinue GLP-1s.[0] The premise, IIUC, is that obesity is driven partly by mucosal overgrowth on the duodenum. This thicker-than-expected layer of mucus is less porous, which leads your digestive system to underestimate the number of calories you've consu…

https://en.wikipedia.org/wiki/Duodenum

Fascinating.

Re: Weight loss jabs: What happens when you stop taking them

#80

Post by neom »

maxaw wrote: post #69

I definitely lost weight easily on wegovy and just as easily gained it back when I stopped taking it. The whole experience definitely drove home how I needed to improve my mental health alongside any “purely physical” intervention. Same situation when I lost weight by meticulously calorie counting. I think obesity is hard to fix even when you are not a “thermodynamics denier” (as another commenter said) because all y…

Excuse the ramble: it maybe sucks more for people with eating addictions than alcohol in some sense. I am an alcoholic and I've been sober for, I dunno, years and years now. I did actually go to pubs and cocktail bars when I first got sober, I didn't drink I just sat and felt awful and wanted to drink badly. I felt I needed to learn how the feeling of the craving was going to work so I can plan for it etc, especially when stress creeps in. So, as another comment said, I got sober by stopping the first drink. For me it's very logical, if I have a drink, I will drink, I will not stop, I cannot stop, so if I take the first drink it doesn't matter that is is, it's done, so I don't drink the first drink since I decided that, hence sober.

...I suppose it's hard for someone who struggles with eating to stop food all together. That said, after I got off booze, I started on sugar, never been into sugar in my life, didn't like cake, ice cream any of that stuff, but getting off booze that started, I craved ice cream and stuff all the time, and gave in not realizing what was happening, once I told my dr and he explained the body was substituting the alcohol... so I stopped sweet stuff (mostly all of it, honey and fruit juice seem fine, I don't crave them). I don't have very many cravings any more, I know that "you're going to crave this if you have it more than a few times" feeling as soon as I consume something now, and, I just, don't. Is it hard? Every time, but I prefer the control more tbh.

Maybe I live a kinda boring life now, oh well, at least I feel great.

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