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Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

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Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#72
post #66

Earlier quoted context omitted.

Couldn’t it be the other way round, that changes in health caused by other external factors erroneously get blamed on COVID? For instance, a disproportionate amount of long COVID cases are reported by women between the ages of 40 and 60, the exact age range when most women experience menopause [0]. Menopause can cause brain fog, fatigue, and other symptoms that mirror those of long COVID. Since pretty much everyone h…

Ah yes, you trust https://www.newsonhealth.co.uk/ over research from Harvard. One, maybe two non-research docs or... a team of research docs.

Fine, here's a source where both the second and corresponding authors are from Harvard that says the same thing [0]. That said, you don't need to be from a prestigious institution to observe the basic statistic that long COVID is most frequently reported in women ages 40-60.

[0] https://jamanetwork.com/journals/jamanetworkopen/fullarticle...

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#73

Can someone knowledgeable explain the current understanding of Covid’s long time effects? I thought it was still a big unknown and long COVID was still debated as to even having a clear definition.

I find the occasional research roundups from the “your local epidemiologist” newsletter informative:

https://yourlocalepidemiologist.substack.com/p/long-covid-re...

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#74

Earlier quoted context omitted.

No, you are parsing this wrong. > We evaluated the diagnostic power (...). We estimated a 94% accuracy for (our method), significantly higher than the (traditional method) (66% accuracy). Both methods have counting in their name, but they are comparing the diagnostic power.

after reading more - you're right, I'm wrong

I appreciate the frank acknowledgment of your mistakes. We need more people like you.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#75
post #34

The paper claims that 1/5 of people experience Long COVID after an infection. Given that approximately everyone has caught COVID by now, this does not track with how rarely I've heard of people with it. Wikipedia lists much lower numbers on https://en.wikipedia.org/wiki/Long_COVID (6–7% in adults, ~1% in children, less after vaccination.) and seems to use a more liberal definition than this paper, as it mentions "Mos…

I'm an ambulance chaser. I look at medical records all day. I've never seen anyone complaining of long covid.

Most people don't even know to look for it, including doctors. Some cardiac doctors are finally beginning to take the research more seriously, however. It's slow going for everyone involved.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#76
post #15
post #12

Earlier quoted context omitted.

If this were the case you could do a natural study on this by comparing menstruating women with the rest of the population

This has been done. Women seem to have certain health benefits that stop after menopause. Reading about it was the first time I wondered whether blood letting made sense.

God, this is so ignorant, the hormonal changes (loss of estrogen) are the cause of increased risks for heart disease and osteoporosis and changes in metabolism post-menopause. Nothing to do with not physically losing blood, FFS.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#77
post #8
post #6

This is (probably) not a Long Covid story but I found that bloodletting (for which I even received money!) gave me back the energy that I was missing for the last few years (e.g. it was impossible to build stamina). I also read about a study about the positive effects of bloodletting[1] that somehow is not all the rage in mainstream news, which I find perplexing. If it might be so easy to improve your health (for som…

The lower blood pressure I can explain by having a lower volume of blood. But the glucose and cholesterol have to go somewhere. Where do they go? Are they filtered in the process after blood letting?

Let's just pretend it's accurate and say your body burns 2000 kcal a day. If you have less glucose in your blood overall after giving blood, even if the ratio should theoretically remain the same, your body is still going to burn 2000 kcal anyway, and maybe the blood glucose equilibrium reaches a lower level.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#78

Can someone knowledgeable explain the current understanding of Covid’s long time effects? I thought it was still a big unknown and long COVID was still debated as to even having a clear definition.

The WHO [1] has a clinical definition of the disease and some basic data on chance of Covid infections turning into Long Covid. Then the meta study by Eric Topol and Zayad Ali-al from last year is probably a good primer into what is known about the disease that is well established science [2]. Its not a big unknown anymore, its very prevalent, it has a lot of symptoms, it has a clinical definition but its problematic…

The first link is not a clinical definition, the second link is not a "meta study" (it's a substack article with absolutely no rigor). Moreover, the first link cites prevalence numbers wildly in conflict with the second link:

> Approximately 6 in every 100 people who have COVID-19 develop post COVID-19 condition

vs., for example:

> From one center in Wuhan, 1,359 survivors completed 3-year follow up and 54% had at least one persistent symptom of Long Covid

This only underscores the lack of clinical definition. Both of these suffer from the same fundamental error, which, again, is that there's no precise definition of the syndrome. They include symptoms that are common amongst healthy people, mix them with less-common things that are associated with Covid (e.g. anosmia) and try to call this a disease state. See the WHO's grab-bag list of possible inclusion criteria:

> Over 200 different symptoms have been reported by people with post COVID-19 condition. Common symptoms include: fatigue, aches and pains in muscles or joints, feeling breathless, headaches, difficulty in thinking or concentrating, alterations in taste.

So literally having "headaches" or "aches and pains" is enough to claim Long Covid, according to the WHO.

The Topol/Aly substack engages in the same logic, and you will see that the referenced charts and graphs cover everything from fatigue to heart attack. Aly, in particular, has based his entire long covid research on a single dataset of (largely elderly, unhealthy prior to infection) VA patients that he refuses to release, and routinely engages in statistical fishing expeditions for new "symptoms" within that dataset.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#79

The paper claims that 1/5 of people experience Long COVID after an infection. Given that approximately everyone has caught COVID by now, this does not track with how rarely I've heard of people with it. Wikipedia lists much lower numbers on https://en.wikipedia.org/wiki/Long_COVID (6–7% in adults, ~1% in children, less after vaccination.) and seems to use a more liberal definition than this paper, as it mentions "Mos…

Society is very stratified by intelligence, and the predispositions to long covid, like generalized joint hypermobility (GJH) strongly correlates positively with intelligence. See the work done by Dr Jessica Eccles on Bendy Brains Bendy Bodies and her published studies on long covid.

Anyway, because of the stratification many people don’t know anyone with long covid, while at the same time half of my friends have it. Both can be true observations of our surroundings.

On the actual numbers I would say that ~10% get some level of Long Covid while half of those recover in the first year. Of those who don’t recover around half have GJH which is a massive over representation suggesting a strong predisposition.

Re: Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients

#80

The paper claims that 1/5 of people experience Long COVID after an infection. Given that approximately everyone has caught COVID by now, this does not track with how rarely I've heard of people with it. Wikipedia lists much lower numbers on https://en.wikipedia.org/wiki/Long_COVID (6–7% in adults, ~1% in children, less after vaccination.) and seems to use a more liberal definition than this paper, as it mentions "Mos…

It takes very severe disability for it not to be brushed off as depression, anxiety, burnout, or blamed on lifestyle. Additionally, a lot of those numbers are based on earlier strains of COVID, which were much more severe. I suspect the 1/5 figure is largely true for "has some degree of cardiovascular damage and worsened general health after COVID", but the number of people actually disabled by the condition is much…

> Additionally, a lot of those numbers are based on earlier strains of COVID, which were much more severe.

Long COVID associated with SARS-CoV-2 reinfection among children and adolescents in the omicron era

https://www.thelancet.com/journals/laninf/article/PIIS1473-3...

(The same omicron era the media originally claimed was "not as bad as previous variants." Perhaps not in the acute phase, but as we've seen, that's the least of anybody's concerns who track the longterm risks.)

> I am incredibly disappointed that we did not introduce any shared indoor space air quality legislation post-pandemic.

That seems like a tempting thing to lament, and I did too until seeing this recently:

Study finds HEPA purifiers alone may not be enough to reduce viral exposure in schools

https://www.eurekalert.org/news-releases/1101354

This suggests our most reliable protection to date is consistent N95 usage (since present vaccines don't reliably prevent transmission) until next gen vaccines are developed.

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