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Dopamine signals when a fear can be forgotten

picower.mit.edu

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Re: Dopamine signals when a fear can be forgotten

#71
post #10
post #5

I have a simple question. How do I control dopamine in "my" brain so that I can focus on "here and now" instead of HN and GitHub.

Strengthen your prefrontal cortex so "you" have more control over your urges. You typically do this with meditation.

Any special kind of meditation that is recommended?

Re: Dopamine signals when a fear can be forgotten

#72

This line in the article is horrifying : > The researchers were surprised that when they activated VTA dopaminergic inputs into the aBLA they could reinstate fear even without any new foot shocks, impairing fear extinction. That... seems like the first step in being able to literally induce fear without having to bother with pesky things like finding the subject's triggers. Although I suppose if one has direct access…

I feel like this would deprive the FSB/ICE/law-enforcement officials of their entire motivation for taking pride in their jobs. Automate the paperwork, yes, but let the psychopaths have their fun!

Re: Dopamine signals when a fear can be forgotten

#73
post #68
post #64

Earlier quoted context omitted.

OK, maybe not "just a precursor" but still "just a neurotransmitter". I've read "The Molecule of More" and as much reasonably looking material I could find on the subject to "understand" my ADHD and fight it w/o meds. And I still feel dumb. Could you please explain how dopamine "participates directly in this functionality"?

FTA: “The team showed that indeed they express “D1” receptors for the neuromodulator. Commensurate with the degree of dopamine connectivity“ There are receptors specifically for dopamine on the amygdala neurons. Dopamine molecules are released by the pre-synaptic neurons, travel across the synapse, and bind to these receptors. Dopamine’s role in the nervous system is not simply an intermediate on the pathway to produ…

The more I read and interact with people like you, the dumber I feel. Thanks. I'll read up.

Re: Dopamine signals when a fear can be forgotten

#74

When you see headlines (or hear podcasters) talk about dopamine and other neurotransmitters, remember that neurotransmitters are merely signaling molecules. The correct way to interpret this study is that dopamine is part of the signaling chain involved in fear extinction. The specific details of where, how, and when that dopamine moves through the brain are important. The wrong way to interpret these studies is to t…

Turned out that people learning about just lead to them making a fetish out of it, like it’s discrete switch in their brain that gets bumped when they eat a donut.

I wonder what even the point is.

Re: Dopamine signals when a fear can be forgotten

#75

Earlier quoted context omitted.

Neurotransmitters are just "global variables" to the GPU. What the variable does or means is trained. Probably trained in the context of "I/O" signals. E.g. if the chemical also speeds up heart rate or breathing then that becomes part of the training data set. So Dopamine can potentially "do" different things in different examples of the same animal, if environmental training data is sufficiently different.

> Neurotransmitters are just "global variables" to the GPU. No, neurotransmitters are very local. Dopamine exists all throughout your body, including your bloodstream. The dopamine in one location is uncoupled from the dopamine in another location. The dopamine in your bloodstream can't get into your brain. Dopamine within the brain doesn't spill over into entirely different regions of the brain.

is it not true though that activity/threshholds of dopamine synapses can be globally or semi-globally up and down regulated?

Re: Dopamine signals when a fear can be forgotten

#76
post #71
post #10

Earlier quoted context omitted.

Strengthen your prefrontal cortex so "you" have more control over your urges. You typically do this with meditation.

Any special kind of meditation that is recommended?

Basic mindfulness meditation should do the job: https://en.wikipedia.org/wiki/Mindfulness#Watching_the_breat...

Re: Dopamine signals when a fear can be forgotten

#77
post #5

I have a simple question. How do I control dopamine in "my" brain so that I can focus on "here and now" instead of HN and GitHub.

Get away from screens. It's hard to focus on the here and now when the here and now is the soul-deadening sensory-less experience of sitting motionless staring at a flat rectangle of pixels. Go out in the woods. Get your hands dirty. Meet friends at a bar and laugh until your stomach hurts. It's so much easier to be present in the moment when the moment is actually high fidelity and nourishing.

Screens are awesome. They are the heir apparent to the fireplace. A very old human tradition and very cherished.

Outside, right now, people stay on screens all the time. It's the same stuff. Why even bother?

Humans plan ahead. We look towards the future and the past. Not all the time, but a lot of the time.

This carpe diem stuff doesn't seem like the right way to approach the problem given our current technological society.

Also, I'm not gonna party just because someone told me to.

Re: Dopamine signals when a fear can be forgotten

#78
post #16

Earlier quoted context omitted.

1. Cold plunge - high but transient (last for hours). I do it in the morning, after my shower - start the day off right. 2. Exercise - short-term: increases dopamine, serotonin, and a bunch of other good stuff; long-term: increases dopamine receptor density. 3. Caffeine - while doesn't technically increase dopamine, it blocks adenosine receptors which indirectly increases dopamine signalling. But habitual use blunts…

I have found l-tyrosine also being quite helpful when taken occasionally.

Done occasionally it’s fine. It can lead to crashes and also anger or increased irritability. Things that mess with neurotransmitters can be hit or miss. A better long term strategy is to focus on fundamental things that improve the metabolic health of your cells.

One other “light” supplement that can dampen addictive behaviors or cravings is l-theanine.

Re: Dopamine signals when a fear can be forgotten

#79

Earlier quoted context omitted.

I would unironically say this is the how of how adderall works for me. I am distracted from work by anxiety. With medication, I'm not distracted.

Indeed, I was surprised both at the fact that it literally makes me feel better because the drug makes you feel good but also that it calmed my brain down and let me access some inner peace. But also the focus modification is big and I learned so many good habits that now I need much less of it to get stuff done. I wake up and start doing my chores before I even have my first dose!

> it literally makes me feel better because the drug makes you feel good but also that it calmed my brain down and let me access some inner peace.

I mean, there is a reason why it's a controlled substance and is heavily abused all across the world. It works and it works well.

Though, I've been on it for about a decade now, and I have lost a large majority of the benefits it once provided.

Re: Dopamine signals when a fear can be forgotten

#80
This is a really cool study—finally shows that dopamine isn’t just about reward but actually acts as the “all-clear” signal that lets the brain unlearn fear. By watching dopamine neurons light up when an expected shock doesn’t happen, and then using light to tweak that pathway, they prove dopamine release in the amygdala actively drives extinction rather than just tagging along. It’s exciting because it hints at new ways to boost therapies for PTSD and anxiety by tweaking that VTA→BLA circuit or D1 receptors
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