Earlier quoted context omitted.
QubesOS is best enjoyed with a hefty CPU, lots of SSD space and a multi-screen set-up (in my opinion). Have you tried using Freetube instead of Youtube? In my experience it works a little better.
The most annoying issue I had was that even using mpv would lead to audio samples being dropped. I think I fixed it eventually by increasing buffer sizes, but I would expect at least audio should work out of the box.
I imagine audio and other realtime loads having problems the most on a heavily virtualized system like this.