71–80 of 163 posts
> and results published Wednesday show it worked nearly as well in men. So not as well? Is there a biological reason for this? Also, is it typical to do such studies on single genders rather than on a mix of humans?
Earlier quoted context omitted.
In the United States, of the other available options, to my knowledge, only Truvada is cheap. Discovy is absurdly expensive and the shot is probably also very expensive. And the daily medication has all the downsides of daily medication. To compare to another daily medication, "The Pill" is only 93% effective because people forget to take it.
You'd think people would be more diligent if it was saving their life. I wonder what the effectiveness rate is for, say, heart medication?
Not great, in general. Obviously some people will comply perfectly and never, never miss a dose, but that's not the norm, and for heart medication in particular, that's a mostly elderly demographic.
This is incredibly exciting! The main method available for PrEP, in the United States, at least, is a daily pill. I think (I don't know) there is a monthly shot, too. Daily pills take a lot of time investment; monthly shots are better; but once every 6 months is awesome! Especially in circumstances where it might be difficult to guarantee a daily pill or even a monthly shot.
This treatment does not in fact prevent HIV infection. It prevents infected cells from producing viable virus particles. Because of this, it seems very likely that if any patient being treated with this drug ever discontinued it, they could develop HIV quickly from cells that were already infected in their body that had been suppressed from producing virus particles but were no longer suppressed. I was not able to fi…
This treatment does not in fact prevent HIV infection. It prevents infected cells from producing viable virus particles. Because of this, it seems very likely that if any patient being treated with this drug ever discontinued it, they could develop HIV quickly from cells that were already infected in their body that had been suppressed from producing virus particles but were no longer suppressed. I was not able to fi…
The problems are bigger than that. The trials don't attempt to show impact on AIDS itself. Biomarker studies like this have a long history of going wrong due to statistical or theory related problems.
People with HIV and on ARVs don't develop AIDS either, and any study that watched people contract HIV but didn't provide their participants with ARVs would be both unethical and pointless.
Amazing, but surely you don't need to keep getting the shot once you've got HIV.
This is incredibly exciting! The main method available for PrEP, in the United States, at least, is a daily pill. I think (I don't know) there is a monthly shot, too. Daily pills take a lot of time investment; monthly shots are better; but once every 6 months is awesome! Especially in circumstances where it might be difficult to guarantee a daily pill or even a monthly shot.
The problem is the cost, in Europe and the USA the treatment is over $40,000 USD per year, which isn't realistic for regular people.
Earlier quoted context omitted.
> Do you have kids, if so how do you deal with frequent disruptions to the morning routine? Do you not have days where you just need to get up and go e.g. to catch a flight, get to a meeting, take a kid to school, or because you stayed up late and got drunk, etc... and taking vitamins took a back seat? This is crazy. You deal with the morning routine by taking your pills when the alarm goes off, because there's nothi…
> because there's nothing the kids can be doing that won't wait for that. I feel you don't have young kids then. Jumping on you, bleeding, having a nightmare, making possibly-chocking-sounds, running away with your pills, vomiting on the floor, etc. will definitely take priority over whatever you thought you were going to do after waking up. And that doesn't even touch on people with executive functions issues. Or th…
No, you're just desperately hoping to imagine a scenario that might make it difficult to take a pill with a one-minute take-it-now-or-die window. You're crazy, and you should try to refrain from arguing like that.
The only one of the things you mentioned that could even take priority over a scheduled pill is choking, though you should know that choking doesn't make a sound -- the whole problem with choking is that it blocks airflow -- so if the kid is making sounds, they're not choking. If your kid runs away with your pills, first, that implies that you keep them somewhere your kid can get them (?!), and second, catch them and take the pills back.
Most of what you mentioned is random nonsense that wouldn't even interfere with you. If a little kid jumps into you while you're swallowing a pill, you can just... keep swallowing. If they throw up on the floor, there's nothing time-sensitive about that in any way.
> I feel you don't have young kids then.
I don't, but then again, I have a brother and sister who were born when I was 16. I seem to have more relevant experience than you do. Learn to tell the difference between an emergency and a nothing.
Earlier quoted context omitted.
The problems are bigger than that. The trials don't attempt to show impact on AIDS itself. Biomarker studies like this have a long history of going wrong due to statistical or theory related problems.
HIV isn't a biomarker, it's the cause of AIDS. People without detectable HIV don't develop AIDS. People with HIV and on ARVs don't develop AIDS either, and any study that watched people contract HIV but didn't provide their participants with ARVs would be both unethical and pointless.
> People without detectable HIV don't develop AIDS.
An AIDS diagnosis requires the presence of HIV so your statement is a tautology (not your fault). If we rephrase to what you meant, that people without detectable HIV don't develop AIDS or any identical set of symptoms, then actually they do but when it happens it goes by a different name (ICL, idiopathic CD4 T lymphocytopenia).
ICL is what they call AIDS that appears in HIV negative people and is essentially ignored by the public health community, as it's not supposed to exist.