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Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

nbcnews.com

71–80 of 214 posts

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#71

How long has Ozempic been around? I've never heard of it until very recently (maybe the last month or two) and suddenly I'm seeing it all the time. Maybe this is an instance of Baader-Meinhof phenomenon, but it doesn't feel like it.

Trials started in 2008 AFAICT: https://en.wikipedia.org/wiki/Semaglutide#History

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#73

> nationwide database of electronic health records (EHRs) of 116 million US patients. If you are expert in this space: Is such a dataset available publicly? If so, are there examples of other studies that have used this? Where does one go to read more about the mechanism of this study? Thanks!

Likely this is some aggregator in the Healthcare space that uses tools that effectively fingerprint patients in each EHR.

This deduplicates patients and lets them find specific details like which medications they are on without knowing any PII.

It's very common for researchers within health systems to want to collaborate and combine populations to perform retroactive data analysis.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#74

According to this article, it's been (sorta) reproduced once, which is better than most studies. About 40-60% of scientific studies are not reproducible. Given that, I'd want to see more reproductions. Also, I'm very annoyed by our American culture which tries to fix problems with drugs, rather than preventing them from happening in the first place with good diet, exercise, sleep and stress management.

These aren't preventative drugs, they are to treat people who are already fat.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#75

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

It'll never happen, as long as American culture views body weight as a moral failing. We can't make it easy for people to fix the things we want them to fix, after all.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#76

Earlier quoted context omitted.

GLP-1 have already been on the mass market longer than Fen-Phen (7-years for Fen-Phen Vs. 15+ years, even just Semaglutide has been available longer than Fen-Phen now, and Semaglutide is a third-gen GLP-1). Honestly, this retort can be made about any/all new drugs entering the market. If you had a legitimate retort/critique I'm sure you would have presented it, but this is all we get. This is what happens when you st…

Ultimately the main reason it's bad right now is it's expensive. Far beyond the amount needed to recoup research investment and far far far far far far far far far beyond what it takes to synthesize. Low-end cost of $1000 a month is a lot. That's an expensive car lease, or half a cheap mortgage.

I fully agree. Least of all because it is sold at between $60-200 abroad full-priced. Those countries just have price controls; the pharmacies are still making 80%+ profit margins in those places.

Ultimately, a lot of people will literally die because of this greed. That isn't hyperbole.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#77

Earlier quoted context omitted.

oh, so i guess you live outside and hunt animals for food? how's your all-natural neurochemical reward system?

If I'm not completely natural, then the entire population should have access to subsidized ozempic. Got it.

ie subsidized ozempic means everyone will use it?

You aren't making compelling points by pretending the OPs are stating things they are not.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#78

Why not just lose weight by eating less? I know that sounds like a dumb question. But genuinely, aren’t you just paying money to… not spend the money on food instead?

This is like asking why ADHD patients don’t just get over it by focusing more.

I would state it in a kinder way maybe, but at the end of the day that's basically what you have to do? ¯\_(ツ)_/¯

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#79

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

It is such a fucking no-brainer. The costs of obesity, both monetary and in terms of human suffering, are staggering. Absolutely fucking staggering. We should be making this as available as humanly possible, NOW.

Re: Ozempic linked to lower Alzheimer's risk in people with Type 2 diabetes

#80

Of all things my taxes go to, I would love it the United States Government would buy the patent for this drug and make it freely available to anybody who wants it. The number of things it apparently just cures is staggering.

I have been on compounded GLP-1 for a month, prior to this I was a highly functional alcoholic, basically starting drinking after work every night and going until I passed out. I've drunk well over 50 beers (probably more) a week for the last 20 years. I have not had a drink since going on it. I have been reading obsessively about this drug since going on it. I have been fortunate enough not to suffer side effects on…

2.5mg?
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