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Psilocybin bests SSRI for major depression in first long-term comparison

medscape.com

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Re: Psilocybin bests SSRI for major depression in first long-term comparison

#71

Post by phoronixrly »

farts_mckensy wrote: post #65
phoronixrly wrote: post #49

Earlier quoted context omitted.

> I often hear people talk about the risks of psychedelics, which are to be considered, but what’s the risk of doing nothing or withholding the best treatment? The risk is to make things worse. And I know that I am preaching to people that are of the opinion that they know better than the FDA, scientists and doctors and are all for self-medicating based off of the echo chamber here and a few cherry-picked, limited an…

Is there any evidence that psilocybin "makes things worse" or are you just concern trolling?

The best thing to do is to consult with a physician on this matter, еven if side effects, drug interactions and precautions are readily available and cardiac arrest and death are among them. Idk, is this worse?

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#72

Post by tastyfreeze »

dymk wrote: post #54
Jerrrrrrry wrote: post #30

Earlier quoted context omitted.

The 2018 Hemp Farm bill gave the balls back to the citizens that the 2013 Analag act neutered. Seeing mushroom extracts with all the alkaloids included besides psilocybin at gas stations may be a temporary point of stability until I can go to the "21+" store in 2030 to get my preferred arylcyclohexylamine and phenylethylamine variant.

From what I understand, those “magic mushroom” edibles sold in head shops and gas stations are amanita muscaria derived, which is a completely different psychoactive substance with different alkaloids. Toxic to the liver too, in ways that a cubensis is not.

Northern shamans drank reindeer urine after the animals had eaten amanita muscaria. Passing through the animals reduced the toxic component but left enough alkaloid to trip balls. Maybe the gas station edibles have removed the toxin.

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#73

Post by ValentinA23 »

bitcurious wrote: post #45
ValentinA23 wrote: post #5

https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_i... >Post-SSRI sexual dysfunction (PSSD)[62][63] refers to a set of symptoms reported by some people who have taken SSRIs or other serotonin reuptake-inhibiting (SRI) drugs, in which sexual dysfunction symptoms persist for at least three months[64][65][66] after ceasing to take the drug. The status of PSSD as a legitimate and distinct pathology is contentiou…

Can psilocybin restore the mojo, or are you just commenting on the downside of SSRIs?

Not a cure but a treatment (sample size: 1)

https://www.reddit.com/r/pssdhealing/comments/10tjyen/a_trea...

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#74

Post by dingnuts »

phoronixrly wrote: post #68
HKH2 wrote: post #63

Earlier quoted context omitted.

I don't want people self-medicating with psilocybin, just like I don't want people self-medicating with SSRIs. Which is more dangerous?

The best thing to do is to consult with a physician on matters related to your health.

that's easy to say when you forget about the state of healthcare.. everywhere, actually. I was going to say the US but in other countries it's not like you can just pop in for a chat about taking shroomies, either.

I'm not sure having a ten minute meeting with a stranger who has a PhD in internal medicine is going to yield useful strategies for curing the existential dread underpinning your depression whether you're there to discuss getting zonked on LSD or something more "traditional" like Xanax

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#75

Post by phoronixrly »

maeil wrote: post #70
phoronixrly wrote: post #68

Earlier quoted context omitted.

The best thing to do is to consult with a physician on matters related to your health.

That's not clear cut. There clearly exist plenty of combinations of "situation + physician" where this is not the best thing to do. To claim otherwise may as well be religious dogma.

I'm sorry, but how is trusting a person who dedicated 10+ years of their life studying/practicing this, and relying on rigorous safety and effectiveness research of drugs religious dogma? Are you sure you know what religion is? Are you sure you know what science is? Are you just trolling?

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#76

Post by bobthepanda »

maeil wrote: post #70
phoronixrly wrote: post #68

Earlier quoted context omitted.

The best thing to do is to consult with a physician on matters related to your health.

That's not clear cut. There clearly exist plenty of combinations of "situation + physician" where this is not the best thing to do. To claim otherwise may as well be religious dogma.

At the very least, consulting with one or more physicians gives more data points than you would otherwise have. If your goal is to know more, having other opinions is pretty fundamental.

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#77

Post by striking »

HKH2 wrote: post #63
phoronixrly wrote: post #49

Earlier quoted context omitted.

> I often hear people talk about the risks of psychedelics, which are to be considered, but what’s the risk of doing nothing or withholding the best treatment? The risk is to make things worse. And I know that I am preaching to people that are of the opinion that they know better than the FDA, scientists and doctors and are all for self-medicating based off of the echo chamber here and a few cherry-picked, limited an…

I don't want people self-medicating with psilocybin, just like I don't want people self-medicating with SSRIs. Which is more dangerous?

Psylocybin? Easily?

You have to put effort into making an experience with psylocybin meaningful and helpful. It could go wrong very easily, especially for those who are in a difficult situation or headspace. (Speaking from experience.)

As for SSRIs? Safe, effective, with a handful of annoying side effects. Straightforward to use, low potential for misuse, requires sustained use for any intended effects. A doctor who already has familiarity with a patient's mild or moderate symptoms of anxiety or depression may very well just prescribe one if asked and if not contraindicated. Not that you should randomly start popping Prozac, but it's unlikely to hurt you if you did.

Ask your doctor, try the things that doctors currently believe are most likely to work first. If for whatever reason you choose to go beyond the current medical consensus, please stay safe and keep your doctor up to date.

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#78

Post by phoronixrly »

dingnuts wrote: post #74
phoronixrly wrote: post #68

Earlier quoted context omitted.

The best thing to do is to consult with a physician on matters related to your health.

that's easy to say when you forget about the state of healthcare.. everywhere, actually. I was going to say the US but in other countries it's not like you can just pop in for a chat about taking shroomies, either. I'm not sure having a ten minute meeting with a stranger who has a PhD in internal medicine is going to yield useful strategies for curing the existential dread underpinning your depression whether you're…

> it's not like you can just pop in for a chat about taking shroomies

You sure can just pop in to discuss options for your crippling depression though? And sorry, I do indeed live in a country with a functioning healthcare system, not the US.

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#79

Post by dyauspitr »

HKH2 wrote: post #63
phoronixrly wrote: post #49

Earlier quoted context omitted.

> I often hear people talk about the risks of psychedelics, which are to be considered, but what’s the risk of doing nothing or withholding the best treatment? The risk is to make things worse. And I know that I am preaching to people that are of the opinion that they know better than the FDA, scientists and doctors and are all for self-medicating based off of the echo chamber here and a few cherry-picked, limited an…

I don't want people self-medicating with psilocybin, just like I don't want people self-medicating with SSRIs. Which is more dangerous?

Definitely psilocybin. For instance, if you take psilocybin and then spend some time in a cow slaughterhouse house, you might go crazy. The same wouldn’t be true of SSRIs.

Re: Psilocybin bests SSRI for major depression in first long-term comparison

#80

Post by bobthepanda »

iluvcommunism wrote: post #67

It’ll be good to find positive effects in natural remedies like this. It is ironic we try to keep people safe from themselves but end up dolling out ineffective or destructive drugs instead. A case in point, opium being illegal, but a lab derivative 1k stronger fentanyl, legal and 300k killed globally over the last 10 years.

Where are you that fentanyl is legal in a way opium is not? In the US both are schedule II and approved for medicinal use.
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