Live data from Hacker News

Your Immune System Is Not a Muscle

rachel.fast.ai

71–80 of 202 posts

Re: Your Immune System Is Not a Muscle

#72

Very much disagree with the implication that helminths will help very much for these conditions. While not a commonly known treatment in the 'medical sphere' it's is very commonly known in the 'patient community spheres' and from the patient run studies it does not appear to have a particularly strong effect. It does appear to help some people so it's hard to rule it out but that could easily be noise. Those who did…

The Th1 program in a T-helper cell suppresses the Th2 response, and vice versa. https://en.wikipedia.org/wiki/T_helper_cell#Th1/Th2_model

Although it's way more complicated than that and there are exceptions, but it's still a real phenomenon.

Community deworming increases Th1 cytokines https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098677/

When you administer helminths to yourself there is no guarantee that they are going to the right spot in your body, etc. which explains why everyone responds differently.

Re: Your Immune System Is Not a Muscle

#73

I don’t know enough to comment on the Hygiene / Old Friends hypothesis, but anecdotally it seems like almost everyone I know now has an allergy or autoimmune disorder of some sort. After giving birth, my sister suddenly developed something similar to celiac disease (but not quite the same; I don’t think doctors ever figured out exactly what it is) to where she can’t eat grains and a few other types of food as well. I…

https://github.com/cutestuff/FoodDepressionConundrum

Been collecting for a while. Latest success was supplementing with a probiotic specifically for oxolates. Prepare the gut with l-glutamine and silicea if you go that route

Re: Your Immune System Is Not a Muscle

#74
post #8

>We can see that not all obstacles make you stronger. Destroy the cartilage in your knee, and it may never fully recover, since cartilage doesn’t grow back. // I'm not a medic but I recall this being disproven or shown to be at least partially a myth a few years ago - https://physicians.dukehealth.org/articles/humans-have-salam... from 2020, for example. Researchers showed that ankle cartilage is younger than knee- a…

It's long been believed that an ACL rupture requires surgery as the ligament does not have sufficient blood flow to repair on its own. But then a recent study showed that in a significant percentage of people who suffer ACL ruptures and elect not to have surgery the ligament eventually repairs itself on its own.

Curious about the ACL study... do you have a link handy?

Re: Your Immune System Is Not a Muscle

#75
post #5
post #3

Interesting that in one of the cited studies the authors are not afraid to claim that viral infections may cause autoimmune diseases, despite the fact that the potential mechanisms they list could also apply to vaccines. "Current research suggests that several mechanisms, such as molecular mimicry, epitope spreading, and bystander activation, can cause viral-induced autoimmunity."

Autoimmune responses are well known with some vaccines and some conditions, such as GBS. Most real experts know that vaccines carry all sorts of risks. It's the general public that is mostly unaware and would find this sort of thing surprising. It's the whole "safe" vs "generally safe" thing.

What is GBS? And the vaccine for it causes autoimmune responses? Can I read more?

Re: Your Immune System Is Not a Muscle

#76
post #30
post #22

My "unpopular opinion" is that in 100 years, people will consider it very strange that most of the population was permanently infected with a bunch of viruses like EBV/HSV/CMV/HPV and nobody cared or did anything about it.

Probably an accurate prediction. Kind of like how large populations in the American south were once infected with hookworm.

Also now we don't have enough hookworm. Cause apparently that has caused a lot of auto immune disorders.

Re: Your Immune System Is Not a Muscle

#77
post #5

Earlier quoted context omitted.

Autoimmune responses are well known with some vaccines and some conditions, such as GBS. Most real experts know that vaccines carry all sorts of risks. It's the general public that is mostly unaware and would find this sort of thing surprising. It's the whole "safe" vs "generally safe" thing.

What is GBS? And the vaccine for it causes autoimmune responses? Can I read more?

GBS is the autoimmune response to many vaccines. In a lot of ways, it's similar to having a stroke in as far as people have to relearn how to do many things, sometimes down to relearning how to walk.

Re: Your Immune System Is Not a Muscle

#78

I don’t know enough to comment on the Hygiene / Old Friends hypothesis, but anecdotally it seems like almost everyone I know now has an allergy or autoimmune disorder of some sort. After giving birth, my sister suddenly developed something similar to celiac disease (but not quite the same; I don’t think doctors ever figured out exactly what it is) to where she can’t eat grains and a few other types of food as well. I…

Sad to say, the fecal-oral cycle of infection remains common in the USA, with the most common areas of spread being restaurants although hospitals were sadly guilty of this until recently. And for any gastrointestinal illness in the USA, the single most common cause is Helicobacter pylori. Back in the 1980s and 1990s researchers mostly associated Helicobacter pylori with ulcers, but since then the research has expand…

Have a family member being treated for Helicobacter pylori right now! He was very worried it was cancer as the symptoms seemed to align. Interestingly he is allergic to penicillin which is complicating the treatment.

Re: Your Immune System Is Not a Muscle

#79

Earlier quoted context omitted.

Sad to say, the fecal-oral cycle of infection remains common in the USA, with the most common areas of spread being restaurants although hospitals were sadly guilty of this until recently. And for any gastrointestinal illness in the USA, the single most common cause is Helicobacter pylori. Back in the 1980s and 1990s researchers mostly associated Helicobacter pylori with ulcers, but since then the research has expand…

The one thing that shocked me after moving to the States was how no one washed their hands before meals. It's just not a thing.

weird, I've lived in the US most of my life and I think pretty much everyone washes their hands?
Post reply on HN