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Dual action antibiotic could make bacterial resistance nearly impossible
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Re: Dual action antibiotic could make bacterial resistance nearly impossible
#72Earlier quoted context omitted.
But drug resistance is already really hard to develop. As you say, there are an almost unfathomable number of -- let's say staph -- bacteria running around, infecting millions of people per year, and still it's taken most of a century to develop MRSA. 100 million times might make MRSA v2 take millennia to arrive.
As we see an exponential grow or the human population, shouldn’t your estimation for v2 be pondered compared to v1 development?
Actually, the rate of population increase peaked in the 1960s. The growth once seen as exponential is beginning to look like an s-curve, if you pay attention to the derivative.
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#73Step 1: We are overconfident that bacteria won't become resistant to this formula
Step 2: Formula sold to developing countries pharmaceutical industry
Step 3: Antibiotic given to every man, woman, and child with even the most trivial of symptoms
Step 4: Widespread bacterial resistance to dual action antibiotic.
Step 5: rinse, repeat
We need better antibiotic distribution practices before we unleash more formulas on the world. Anything this strong should never be given to farm animals and should not be given to any developing country not willing to implement strong access control on a patient by patient basis (ie verified infection with bacteria that can be controlled with the formula and verified completion of course)
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#74Step 1: We are overconfident that bacteria won't become resistant to this formula Step 2: Formula sold to developing countries pharmaceutical industry Step 3: Antibiotic given to every man, woman, and child with even the most trivial of symptoms Step 4: Widespread bacterial resistance to dual action antibiotic. Step 5: rinse, repeat We need better antibiotic distribution practices before we unleash more formulas on t…
Step 3: even worse, to every pig and cow, to make them grow faster in worse conditions.
I think the main problem is in lack of awareness. People don't understand that antibiotics have downsides. But how to spread awareness without swinging the pendulum too far and creating an ugly stepsister of the anti-vax movement? It certainly seems that humanity doesn't have much capacity for nuanced thought when it comes to "chemicals".
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#75Earlier quoted context omitted.
Hospitals are an environment where they have the advantage and where humans who are most vulnerable are. Outside of a hospital they don't do as well, but the local environments they do well in are still important even if they are a minority. Also, if the bacteria targets humans or things humans treat (cats...) anything not resistant will not survive as well because when we detect sickness we treat it and select for a…
Maybe hospitals is a bad idea then and healthcare should be more distributed, given sufficient resources. Auto doc in every crew quarters.
Research indicates that using copper or copper alloys in hospitals reduces nosocomial infections [0], but people seem to prefer stainless steel because it looks cleaner.
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#76Step 1: We are overconfident that bacteria won't become resistant to this formula Step 2: Formula sold to developing countries pharmaceutical industry Step 3: Antibiotic given to every man, woman, and child with even the most trivial of symptoms Step 4: Widespread bacterial resistance to dual action antibiotic. Step 5: rinse, repeat We need better antibiotic distribution practices before we unleash more formulas on t…
Step 3: even worse, to every pig and cow, to make them grow faster in worse conditions. I think the main problem is in lack of awareness. People don't understand that antibiotics have downsides. But how to spread awareness without swinging the pendulum too far and creating an ugly stepsister of the anti-vax movement? It certainly seems that humanity doesn't have much capacity for nuanced thought when it comes to "che…
https://www.aljazeera.com/features/2016/8/15/what-is-killing...
My argument stems from stories from India of newborns getting multidrug resistant bacteria shortly after birth, presumably from the hospital they were born in because standard medical practice in India is to be given antibiotics for even a minor cough (I have been there long enough and witnessed this firsthand). It’d be really cool if pharmacies there would put up more barriers to distributing these!
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#77Humans: Dual action antibiotic could make bacterial resistance nearly impossible.
Bacteria: Hold my beer.
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#78Earlier quoted context omitted.
What's the best way to allow the liver to recover after such heavy medication?
A question for a doctor for sure. But Wikipedia has a long article on Hepatotoxicity[0] and that suggests discontinuation of the drugs involved can allow the liver to heal (if discontinued early enough). As a patient, you need to be conscious to ask questions and retain at least some control over your treatment whenever you can. If you're overwhelmed by what you are being told or concerned about the planned course of…
doctors don't always answer questions though, most of their line of work involves infantilising patients
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#79[flagged]
Please don't take HN threads on generic flamewar tangents. I'm sure that wasn't your intent, but we got a religious flamewar out of this. Those get predictably worse as they go along, so it's important not to seed them. " Eschew flamebait. Avoid generic tangents. " https://news.ycombinator.com/newsguidelines.html We detached this subthread from https://news.ycombinator.com/item?id=41099534 .
Oh good lord --
1. I'm sorry, I'll try to avoid this happening again.
2. I just saw an opportunity to get a quick answer to a simple question. It never occurred to me that HN wasn't better than this :-(
Re: Dual action antibiotic could make bacterial resistance nearly impossible
#80Earlier quoted context omitted.
Last year I was hospitalized and quarantined for Tuberculosis, which is fairly strong against antibiotics so the antibiotic therapy is 6 months long (minimum), and that's precisely how I was treated, by combining first 4 then 2 antibiotics in order to prevent the bacteria from developing resistance, but you're right, it's super bad for your liver, I've seen heavy alcoholic patients in the same ward that were refused…
What's the best way to allow the liver to recover after such heavy medication?
I was prescribed a drug that's sold under brand name Heparegen over here that I had to take for months, apparently the active compound is called Timonacic: https://drugs.ncats.io/drug/E5913T3IBL
We also had to take these pills twice a day throughout my hospital stay under the supervision of nurses who would ensure we actually take all of our medication.
Also, a few months later of taking this drug, my liver is perfectly healthy (results from around two weeks ago): https://i.imgur.com/WMpH4t9.png
