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Scientists discover links between Alzheimer's disease and gut microbiota

kcl.ac.uk

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Re: Scientists discover links between Alzheimer's disease and gut microbiota

#71

Post by XorNot »

Llamamoe wrote: post #63
XorNot wrote: post #54

Earlier quoted context omitted.

This is asking the wrong question: for example, there are antibiotics you are prescribed for IBS because generally they tend to have a balancing effect on the gut microbiome. I've done a course every year or two when things get unmanageable, since it's a good reset. In this context, a treatment which reduced risk would likely be a combination of antibiotics and probiotics to try and shift the biome to a different one…

This is antibiotic marketing bs. There are antibiotic that harm pathogenic or prone-to-overgrowth bacteria harder than others, but they ALL lead to a state of dysbiosis and susceptibility to subsequent colonization/overgrowth/dysregulation And this is the exact reason whymost of the time, GI problems come back or are replaced with different symptoms after antibiotics, and why we need more Fecal Microbiota Transplant…

No, it isn't. The whole point of antibiotics for IBS treatment is that you already have an overgrowth, and you want to disrupt that and level the playing field.

This is literally the reason I've been on short course antibiotics (<1 week or a single 4 tab dose) at different points, because it eliminates the constant bloating and gives probiotics a chance to work.

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#72

Post by mise_en_place »

pajep wrote: post #6
mobilejdral wrote: post #2

I had to triple check the date because I was pretty sure that this was known before. Maybe it is simply the confirmation aspect of it? Edit: > Our findings reveal for the first time, that Alzheimer’s symptoms can be transferred to a healthy young organism via the gut microbiota, *confirming a causal role* of gut microbiota in Alzheimer’s disease ... From: https://faculty.sites.uci.edu/kimgreen/bio/glucocorticoids-a..…

For those that are curious and not well verse in research level biology, what kind of food, drink and lifestyle will help maintain a gut biome that prevent Alzheimer

Generalizing but it seems that harmful microbiota prefers glucose but leaves behind bad metabolic byproducts. Whereas beneficial microbiota leaves behind lactic acid? So maybe lactofermented foods will help.

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#73

Post by entwife »

Aurornis wrote: post #58
noman-land wrote: post #18

Earlier quoted context omitted.

"You could sum up Alzheimer's as: Diet/Lifestyle + a congenital form of Cushing's syndrome and you have increasing glucocorticoids which imply downregulation of the PVN, less progesterone and low levels of Prolactin reducing oligodendrocyte reducing myelin sheaths. Add in APOE e4 without choline in the diet and you have accumulation of lipids to round it all out." Can someone translate this into plain English?

Unfortunately, the parent commenter is making huge leaps of logic and exaggerating the results of various studies. The Reddit source they linked to is from a telehealth medical provider who has invented a new condition and named it after himself. Skimming his writings gives strong pseudoscience / alternative medicine vibes. For example, Cushing's syndrome is a disorder of extreme excess cortisol. The incidence is est…

I agree with Auromis. The reported research is interesting, and yet is not yet ready for application to human health. It's tempting to leap to conclusions. The top poster takes this too far.

I hope that NIH funds a lot more Alzheimer's research looking for microbial causes, and also, that the technology for understanding gut microbiome continues to develop.

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#74

Post by JPLeRouzic »

wdwvt1 wrote: post #60

Microbiome researcher here. As usual, when a microbiome paper reaches HN, I emerge to urge caution. You should be extremely skeptical of the larger conclusions drawn from this paper. The biology of Alzheimer's disease (AD) is poorly understood, and the contribution of dietary and microbiome factors are extremely unclear. I think you should treat the evidence from this paper (and shared in this thread) as more like "f…

Many thanks,

It's a bit sad that this comment is in the lower half of the thread, while the comments in the higher half are at the same time: clearly uninformed on the topic and still making strong statements.

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#75

Post by simonswords82 »

wdwvt1 wrote: post #60

Microbiome researcher here. As usual, when a microbiome paper reaches HN, I emerge to urge caution. You should be extremely skeptical of the larger conclusions drawn from this paper. The biology of Alzheimer's disease (AD) is poorly understood, and the contribution of dietary and microbiome factors are extremely unclear. I think you should treat the evidence from this paper (and shared in this thread) as more like "f…

Hey thanks for this info, all of which I'm sure is super insightful for people who understand this level of detail.

What would you say the average person in the street should eat in terms of supplements, vitamins and food in general to maintain excellent microbiome based on your learnings?

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#76

Post by wodenokoto »

wdwvt1 wrote: post #60

Microbiome researcher here. As usual, when a microbiome paper reaches HN, I emerge to urge caution. You should be extremely skeptical of the larger conclusions drawn from this paper. The biology of Alzheimer's disease (AD) is poorly understood, and the contribution of dietary and microbiome factors are extremely unclear. I think you should treat the evidence from this paper (and shared in this thread) as more like "f…

As a micro biome researcher do you think I should be eating more kimchi?

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#77

Post by chiefalchemist »

bagels wrote: post #29
chiefalchemist wrote: post #15

Earlier quoted context omitted.

The usual. The way we evolved: Avoid processed foods and move (i.e., exercise). Obviously, only take antibiotics when absolutely necessary.

What does processed even mean? Unless I run out in the field and bite a cow, that meat is going to be processed. Likewise with potatoes, I'm going to be eating unpalatable starchy uncooked potatoes.

In 2023 it means...

An apple...not processed.

An ear of corn...not processed.

Oatmeal...not processed.

Frozen peas...not processed.

Breakfast cereal...processed.

Heat & serve meals in the frozen section...processed.

Yogurt with fruit (and tons of sugar) pre-added...processed.

Soft drinks...processed.

Kid's "Happy Meal"...processed.

And so on.

Btw, Slaughtered and butchered meats !== processed meats.

Recommened book:

- Exercised - D Lieberman

https://www.theguardian.com/books/2020/aug/29/exercised-by-d...

- Burn - Pontzer

https://www.npr.org/sections/health-shots/2021/07/16/1016931...

- Comfort Crisis - M Easter

- Scarcity Brain - M Easter

https://eastermichael.com/

Also recommended, the series "The Foods That Built America" on the History Channel.

p.s. Again, key phrase "as we evolved". Last I checked archeologist aren't digging up McDonald's from eons ago.

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#78

Post by chiefalchemist »

SoftTalker wrote: post #45
toenail wrote: post #43

Earlier quoted context omitted.

Industrial processing. As a simple rule, the longer the list of ingredients on the food label, the more processed. The ingredients aren't something you'd normally think of as food? More processed.

Basically don't eat food that comes in a box. Eat fresh or frozen meats, vegetables, fruits, some whole grains. In most supermarkets, shop around the perimeter and avoid everything in the center aisles.

Another way I've heard it stated: "single ingredient foods." And as you prepare them, try to keep them that way.

For example, adding a ton of butter to potatoes makes them 10x less healthy. More or less, calorically they become fries. Fries taste great but they should be an occasional treat, not a staple.

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#79

Post by chiefalchemist »

SquibblesRedux wrote: post #32
bagels wrote: post #29

Earlier quoted context omitted.

What does processed even mean? Unless I run out in the field and bite a cow, that meat is going to be processed. Likewise with potatoes, I'm going to be eating unpalatable starchy uncooked potatoes.

> Unless I run out in the field and bite a cow Oh, how I now want to invent a new fad diet...

Given the question, I'm willing to bet that running is likely to result in a heart attack.

Re: Scientists discover links between Alzheimer's disease and gut microbiota

#80

Post by quickthrower2 »

lapetitejort wrote: post #13
datameta wrote: post #10

Earlier quoted context omitted.

Fatty fish, most nuts (that don't have high omega-6, which is inflammatory), fruits high in antioxidants like berries and dark fruit in general, colorful vegetable, cooking with olive/avocado/sunflower oil, *kefir* which is the champion of all good microbiota inducers As for avoiding : red meat (high in omega-6), gluten (chickpea, rice, lentil pasta instead of wheat), cooking with hydrogenated oils, preservatives, pr…

I'm a fermentation freak so I have to highlight how uncooked fermented foods like sauerkraut and the aforementioned kefir play into anti-inflammation [0]. [0]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147091/

kimchi too?
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